A5051115596- Cancer, Lipids, and Metabolism
- Health disparities and outcomes
- Fatty Acid Research and Health
- Biopolymer Synthesis and Applications
- Nutrition, Genetics, and Disease
- Dementia and Cognitive Impairment Research
- Dialysis and Renal Disease Management
- Nutritional Studies and Diet
- Phytoestrogen effects and research
- Digestive system and related health
- Urban Transport and Accessibility
- Helicobacter pylori-related gastroenterology studies
- Suicide and Self-Harm Studies
- Global Maternal and Child Health
- Liver Disease Diagnosis and Treatment
- Global Health Care Issues
- COVID-19 epidemiological studies
- Esophageal Cancer Research and Treatment
- Child Nutrition and Water Access
- Muscle metabolism and nutrition
- Biological Research and Disease Studies
- Colorectal Cancer Screening and Detection
- Lung Cancer Treatments and Mutations
- Climate Change and Health Impacts
- Nutrition and Health in Aging
Shenzhen Institutes of Advanced Technology
2020-2025
Chinese Academy of Sciences
2021-2025
Vanderbilt University Medical Center
2012-2024
China State Construction Engineering (China)
2024
Institute for Health Metrics and Evaluation
2020-2024
University of Washington
2020-2024
Harvard Pilgrim Health Care
2023
Sun Yat-sen University
2023
Harvard University
2023
Vanderbilt University
2016-2022
Objective This present study aims to estimate the structural validity, internal consistency reliability of LSNS-6 and examine associations between suicidal outcomes among mainland Chinese older adults. Methods validation used a big representative sample (N = 2819) adults in Beijing from Sample Survey on Aged Population Urban/Rural China. Confirmatory factor analyses (CFA) were applied structures version LSNS-6. Internal was examined by Cronbach's alpha coefficient corrected item-total...
BackgroundConstipation is generally considered a common physical symptom of depression or side effect antidepressant treatments. However, according to the gut-brain axis hypothesis, association between and constipation might be bi-directional. This study investigated premorbid depression.MethodsWe conducted retrospective cohort using data from UK Biobank. Individuals free 2006 2010 were included. Constipation status was determined diagnostic codes electronic health records baseline...
This study assessed the public's health risk awareness of urban air pollution triggered by three megacities in China, and data are responses from a sample size 3868 megacity inhabitants Shanghai, Nanchang Wuhan. Descriptive analyses were used to summarize respondents' demographics, perceived risks sources health-related knowledge on pollution. Chi-square tests examine if participants' demographics associated with participant's general attitudes towards current quality highest due We found...
BACKGROUND. Systemic inflammation and muscle wasting are highly prevalent coexist in patients on maintenance hemodialysis (MHD). We aimed to determine the effects of systemic skeletal protein metabolism MHD patients.
Overweight and obesity affect 340 million adolescents worldwide constitute a risk factor for poor mental health. Understanding the association between body mass index (BMI) health in may help to address rising issues; however, existing studies lack comprehensive evaluations spanning diverse countries periods.
Kidney size adaptively increases as mammals grow and in response to the loss of 1 kidney. It is not clear how kidneys themselves or if processes that adapt kidney mass lean body also mediate renal hypertrophy following unilateral nephrectomy (UNX). Here, we demonstrated mice harboring a proximal tubule-specific deletion Pten (Pten(ptKO)) have greatly enlarged result persistent activation class I PI3K/mTORC2/AKT pathway an increase antiproliferative signals p21(Cip1/WAF) p27(Kip1)....
The adult kidney plays a central role in erythropoiesis and is the main source of erythropoietin (EPO), an oxygen-sensitive glycoprotein that essential for red blood cell production. Decreases renal pO2 promote hypoxia-inducible factor 2-mediated (HIF-2-mediated) induction EPO peritubular interstitial fibroblast-like cells, which serve as cellular site synthesis kidney. It not clear whether HIF signaling other types also contributes to regulation Here, we used genetic approach mice...
Objective The study empirically quantifies the contributions of age composition and urbanisation to changes in suicide rate China over periods 1990–2000 2000–2010. Methods A decompositional method was used quantify absolute relative structure; age-specific proportion urban population each age-specific, gender-specific urban/rural cohort overall rates two 10-year intervals. Results In period between 1990 2000, a significant decline among younger groups (especially young rural women)...
<h3>Background and Objectives</h3> Use of OTC laxatives is common in the general population. The microbiome-gut-brain axis hypothesis suggests use associated with dementia. We aimed to examine association between regular incidence dementia UK Biobank participants. <h3>Methods</h3> This prospective cohort study was based on participants aged 40 69 years without history Regular defined as self-reported most days week for last 4 weeks at baseline (2006-2010). outcomes were all-cause dementia,...
Traditional in-person psychological counseling remains primarily niche, often chosen by individuals with issues, while online automated offers a potential solution for those hesitant to seek help due feelings of shame. Cognitive Behavioral Therapy (CBT) is an essential and widely used approach in counseling. The advent large language models (LLMs) agent technology enables automatic CBT diagnosis treatment. However, current LLM-based systems use agents fixed structure, limiting their...
Background The potential modifiable factors influencing irritable bowel syndrome (IBS) have not been thoroughly documented. We aimed to systematically investigate the associated with IBS, while accounting for impact of unobserved confounders and coexisting disorders. Methods Genetic correlation Mendelian randomisation (MR) analyses were integrated identify disorders linked IBS. Subsequently, multiresponse MR (MR 2 ) was employed further examine these associations. Summary-level genome-wide...
The decreasing suicide rate in China has been regarded as a major contributor to the decline of global past decade. However, previous estimations on China's rates might not be accurate, since often they were based data from Ministry Health's Vital Registration ("MOH-VR") System, which is biased towards better-off population. This study aims compare extracted MOH-VR System with more representative mortality surveillance system, namely Center for Disease Control and Prevention's Surveillance...
The classification of fetuses as Small for Gestational Age (SGA) and Large (LGA) is a critical aspect neonatal health assessment. SGA LGA, terms used to describe fetal weights that fall below or above the expected Appropriate (AGA) fetuses, indicate intrauterine growth restriction excessive growth, respectively. Early prediction assessment latent risk factors associated with these classifications can facilitate timely medical interventions, thereby optimizing outcomes both infant mother....
Abstract Background Recent data suggest that sodium (Na + ) is stored in the muscle and skin without commensurate water retention maintenance hemodialysis (MHD) patients. In this study, we hypothesized excessive Na accumulation would be associated with abnormalities peripheral insulin action. Methods Eleven MHD patients eight controls underwent hyperinsulinemic–euglycemic–euaminoacidemic clamp studies to measure glucose (GDR) leucine disposal rates (LDR), as well lower left leg 23 magnetic...
Previous investigations of geographic concentration urban poverty indicate the contribution a variety factors, such as economic restructuring and class-based segregation, racial demographic structure, public policy. However, models used by most past research do not consider possibility that may take different forms in locations across city, studies have been conducted Western settings. We investigated spatial patterning neighborhood its correlates Hong Kong, which is amongst cities with...
Maintenance hemodialysis (MHD) patients display significant nutritional abnormalities. Insulin is an anabolic hormone with direct effects on skeletal muscle (SM). We examined the actions of insulin, whole-body (WB), and SM protein turnover in 33 MHD 17 participants without kidney disease using hyperinsulinemic-euglycemic-euaminoacidemic (dual) clamp. Gluteal biopsies were obtained before after dual At baseline, WB synthesis breakdown rates similar patients. During clamp, controls had a...
Cystinuria is an inherited disorder of renal amino acid transport that causes recurrent nephrolithiasis and significant morbidity in humans. It has incidence 1 7000 worldwide making it one the most common genetic disorders man. We phenotypically characterized a mouse model cystinuria type A resultant from knockout Slc3a1. Knockout Slc3a1 at RNA protein levels was evaluated using real-time quantitative PCR immunofluorescence. mice were placed on normal or breeder chow diets for cystine stone...
Better modelling of infectious diseases: lessons from covid-19 in ChinaMore timely, accurate, and relevant data methodological innovation could exploit the full power modelling, argue
Secondhand smoke (SHS) exposure is deleterious to pregnant women and their unborn children. The prevalence of SHS among particularly high in many Asian countries where approximately half the male population smokes. We aim investigate efficacy an intervention based on expanded Health Belief Model (HBM) incorporating self-efficacy educate empower reduce exposure.We conducted a 3-arm randomized controlled trial (N = 50 each arm) comparing effectiveness group-based individual-based interventions...