A5101493073- Catalytic C–H Functionalization Methods
- Catalytic Cross-Coupling Reactions
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Cyclopropane Reaction Mechanisms
- Sulfur-Based Synthesis Techniques
- Radical Photochemical Reactions
- Asymmetric Hydrogenation and Catalysis
- Zeolite Catalysis and Synthesis
- Antenna Design and Optimization
- Organoboron and organosilicon chemistry
- Synthesis and Biological Evaluation
- Educational and Psychological Assessments
- Synthesis and Catalytic Reactions
- Antenna Design and Analysis
- Peptidase Inhibition and Analysis
- Coordination Chemistry and Organometallics
- Chemical Reactions and Isotopes
- Mesoporous Materials and Catalysis
- Chemical Synthesis and Characterization
- Chemical Reaction Mechanisms
- Synthesis and Characterization of Heterocyclic Compounds
- Radio Astronomy Observations and Technology
- Advanced Synthetic Organic Chemistry
- Cancer-related gene regulation
Wenzhou Medical University
2019-2025
Xidian University
2022
Wenzhou University
2019-2020
Wuhan Textile University
2020
Taiyuan University of Technology
2012-2015
South China University of Technology
2012
Homoleptic lanthanide complex Y[N(TMS)2]3 is an efficient homogeneous catalyst for the hydroboration reduction of secondary amides and tertiary to corresponding amines. A series containing different functional groups such as cyano, nitro, vinyl were found be well-tolerated. This transformation has also been nicely applied synthesis indoles piribedil. Detailed isotopic labeling experiments, control kinetic studies provided cumulative evidence elucidate reaction mechanism.
A paired electrolysis enabled amination of arenes using N , -dialkyl formamides as the amine source for synthesis arylamines without need chemical oxidants, metal catalysts or high temperatures is reported.
The Pd-catalyzed multicomponent tandem reaction of β-ketonitriles, arylboronic acids and DMSO was efficiently developed, enabling access to a variety poly substituted pyridines. protocol shows excellent chemoselectivity, generating nicotinonitriles or symmetrical tetrasubstituted pyridines under different conditions by cyclization enaminone intermediates with β-ketonitriles enolates, respectively, does not require extra ammonias. This method boasts notable advantages, such as the use...
Herein, a DBU-catalyzed 1,6-Michael addition of para-quinone methides (p-QMs) under mild reaction conditions with high efficiency (turnover number up to 103) and good excellent yields is reported. The transformation proceeds smoothly range nucleophiles, providing diverse diarylmethane scaffolds efficiency. Mechanistic studies revealed that DBU an proton acceptor donor can promote the methanol p-QMs. A preliminary investigation was also conducted antibacterial properties products.
Traditional in-person psychological counseling remains primarily niche, often chosen by individuals with issues, while online automated offers a potential solution for those hesitant to seek help due feelings of shame. Cognitive Behavioral Therapy (CBT) is an essential and widely used approach in counseling. The advent large language models (LLMs) agent technology enables automatic CBT diagnosis treatment. However, current LLM-based systems use agents fixed structure, limiting their...
We report the electrocatalytic α-hydroxymethylation of ketones using DMF as carbon source at room temperature in air a conversion that proceeds without need for toxic and expensive chemical oxidants or metal catalysts.
The Pd(II)-catalyzed cascade reactions of 2-(cyanomethoxy)chalcones with arylboronic acids were demonstrated, allowing the rapid construction benzofuro[2,3-c]pyridine skeletons excellent selectivity. These transformations involve domino-style formation C–C/C–C/C–N bonds through nitrile carbopalladation, intramolecular Michael addition, cyclization, and aromatization. This chemistry allows for thiophen-3-ylboronic acid, providing 3-aryl-1-(thiophen-3-yl)benzofuro[2,3-c]pyridines in moderate...
The first example of nickel complexes as effectively catalyst to C–C, N–C cascade coupling ketonitriles with arylboronic acids, affording 2,5-diarylpyrroles and 2,6-diarylpyridines.
A Pd-catalyzed tandem reaction of 2-(cyanomethoxy)chalcones with heteroarenes (such as thiophenes, furans, pyrroles and indoles) for the synthesis fluorescent benzofuro[2,3-<italic>c</italic>]pyridines.
The first example of the Pd-catalyzed addition organoboron reagents to dinitriles, as an efficient means preparing 2,5-diarylpyrroles and 2,6-diarylpyridines, has been discussed here. Furthermore, highly selective carbopalladation dinitriles with give long-chain ketonitriles developed well. Based on broad scope substrates, excellent functional group tolerance, use commercially available reaction arylboronic acid is expected be significant in future synthetic procedures.
A monofunctional Pt( ii ) complex PtL induces DNA single-strand breaks in triple negative breast cancer and triggers lysosome-dependent cell death by modulating lysosomal function.
The first example of the nickel-catalyzed tandem addition/cyclization 2-(cyanomethyl)benzonitriles with arylboronic acids in 2-MeTHF has been developed, which provides facile synthesis aminoisoquinolines good functional group tolerance under mild conditions. This chemistry also successfully applied to isoquinolones by reaction methyl 2-(cyanomethyl)benzoates acids. use bio-based and green solvent as medium makes process environmentally benign. synthetic utility this is indicated biologically...
An efficient and straightforward protocol for the assembly of valuable oxazole skeleton is achieved first time through palladium-catalyzed C–H activation, carbopalladation a tandem annulation sequence from readily available simple arenes functionalized aliphatic nitriles.
This study presents the first example of Pd-catalyzed cascade reactions 5-oxohexanenitrile with arylboronic acids, affording important synthon 2-methylpyridines that can be further translated through C(sp3)-H functionalization to construct pyridine derivatives. Furthermore, this chemistry allows 5-oxo-5-arylpentanenitrile react acids provide unsymmetrical 2,6-diarylpyridines. protocol paves way for practical and atom economical syntheses valuable pyridines broad functional groups in moderate...
A novel metal-free one-pot protocol for the synthesis of potential biologically active molecules 3-selenylindoles via intramolecular cyclization/selenylation with simple 2-vinylaniline has been developed moderate to good yield, thus representing it as a facile route diverse substitution patterns around indole core. The reaction proceeded smoothly broad substrate scope and excellent functional group tolerance. Moreover, present synthetic could be readily scaled up gram quantity without...
A palladium-catalyzed carbon–carbon bond activation-initiated reaction of 2-(3-phenyloxiran-2-yl)benzonitriles with arylboronic acids is reported. Multiple chemical bonds were cleavaged and reconstructed via β-carbon elimination in this reaction, enabling the construction valuable benzo-fused dipyrromethenes that are difficult to prepare by other methods. Additionally, a series benzannulated boron synthesized show practical significance terms expanding applications types fluorescent...
Pd-Catalyzed tandem reaction of 2-(2-acylphenoxy)acetonitriles or 2-((2-benzoylphenyl)amino)acetonitrile with arylboronic acids for the synthesis 2-aroyl benzofurans and indoles.
The first example of the palladium-catalyzed cascade reaction o-aminocinnamonitriles with arylhydrazines has been achieved, providing an efficient synthetic pathway to access quinolines moderate good yields. Preliminary mechanistic experiments indicate that this process involves sequential denitrogenative addition followed by intramolecular cyclization.
A palladium-catalyzed controllable divergent synthesis of furans and pyrroles through a cascade reaction epoxynitriles with arylboronic acids has been developed in the aqueous phase.
A convenient, efficient, and direct approach toward the synthesis of pyrazino-fused quinazolinone frames has been developed. The photophysical properties <bold>3e</bold> with AIE effect were investigated.
Using large language models (LLMs) to assist psychological counseling is a significant but challenging task at present. Attempts have been made on improving empathetic conversations or acting as effective assistants in the treatment with LLMs. However, existing datasets lack consulting knowledge, resulting LLMs lacking professional competence. Moreover, how automatically evaluate multi-turn dialogues within process remains an understudied area. To bridge gap, we propose CPsyCoun,...