A5024362716- Dialysis and Renal Disease Management
- Nutrition and Health in Aging
- Blood Pressure and Hypertension Studies
- Muscle and Compartmental Disorders
- Iron Metabolism and Disorders
- Muscle metabolism and nutrition
- Cardiovascular Health and Disease Prevention
- Body Composition Measurement Techniques
- Adipokines, Inflammation, and Metabolic Diseases
- Inflammasome and immune disorders
- Parathyroid Disorders and Treatments
- Sodium Intake and Health
- Venous Thromboembolism Diagnosis and Management
- Pharmacological Effects and Toxicity Studies
- Heart Failure Treatment and Management
- Electrolyte and hormonal disorders
- Inflammatory Biomarkers in Disease Prognosis
- Potassium and Related Disorders
- Nutritional Studies and Diet
- Folate and B Vitamins Research
- Chronic Kidney Disease and Diabetes
- Heart Rate Variability and Autonomic Control
- Erythropoietin and Anemia Treatment
- interferon and immune responses
- Renal and Vascular Pathologies
Dokuz Eylül University
2022-2025
Dokuz Eylül Üniversitesi Hastanesi
2024
Yüksek İhtisas Üniversitesi
2019-2020
Vanderbilt University Medical Center
2012-2018
Vanderbilt University
2016-2018
VA Tennessee Valley Healthcare System
2016-2017
Gazi University
2008-2016
BACKGROUND. Systemic inflammation and muscle wasting are highly prevalent coexist in patients on maintenance hemodialysis (MHD). We aimed to determine the effects of systemic skeletal protein metabolism MHD patients.
Abstract Background Tissue sodium (Na+) content in patients on maintenance hemodialysis (MHD) and peritoneal dialysis (PD) was previously explored using 23Na+ magnetic resonance imaging (23NaMRI). Larger studies would provide a better understanding of Na+ stores as well the factors influencing this accumulation. Methods In cross-sectional study, we quantified calf muscle skin 162 subjects (10 PD, 33 MHD 119 controls) 23NaMRI. Plasma levels interleukin-6 (IL-6) high-sensitivity C-reactive...
ABSTRACT Introduction Removing uremic toxins from the body is one of most critical points in maintenance hemodialysis (MHD) population. This study aimed to evaluate effects medium cutoff (MCO) membranes on pulse wave velocity (PWV) and augmentation index (AIx), early markers arterial stiffness, MHD patients over both short‐ long‐term periods. Methods Twenty were included this study. Patients switched low‐flux MCO membranes. Hemodynamic parameters laboratory results recorded membrane as...
ABSTRACT Introduction Cardiac arrest is a common cause of death among patients undergoing maintenance hemodialysis; however, the prevalence and risk factors for cardiac in setting acute kidney injury (AKI) are not studied detail. Methods Patients who received hemodialysis AKI between 2014 2024 were classified as those experienced during (group A) had hospitalization outside session B). Logistic regression analysis was performed to determine odds versus session. Findings Among 1702 AKI, 33...
ABSTRACT Background Medium cut‐off (MCO) dialyzers are designed to provide clearance of large–middle molecular weight uremic toxins and cytokines that also responsible for the pathogenesis sarcopenia. Aim To investigate short‐ long‐term effects MCO on fat muscle mass. Methods This single‐center prospective, cross‐over study includes 20 maintenance hemodialysis (MHD) patients treated with low‐flux (LF) dialyzers. Baseline parameters were measured under LF repeated at 2nd week 6th month after...
T and B cells have been implicated in hypertension, but the mechanisms by which they produce a coordinated response is unknown. follicular helper (Tfh) that interleukin 21 (IL21) promote germinal center (GC) cell responses leading to immunoglobulin (Ig) production. Here we investigate role of IL21 Tfh hypertension. In angiotensin (Ang) II-induced production increased, Il21-/- mice develop blunted attenuated vascular end-organ damage, decreased 17A (IL17A) interferon gamma Tfh-like GC...
Abstract Background Recent data suggest that sodium (Na + ) is stored in the muscle and skin without commensurate water retention maintenance hemodialysis (MHD) patients. In this study, we hypothesized excessive Na accumulation would be associated with abnormalities peripheral insulin action. Methods Eleven MHD patients eight controls underwent hyperinsulinemic–euglycemic–euaminoacidemic clamp studies to measure glucose (GDR) leucine disposal rates (LDR), as well lower left leg 23 magnetic...
Maintenance hemodialysis (MHD) patients display significant nutritional abnormalities. Insulin is an anabolic hormone with direct effects on skeletal muscle (SM). We examined the actions of insulin, whole-body (WB), and SM protein turnover in 33 MHD 17 participants without kidney disease using hyperinsulinemic-euglycemic-euaminoacidemic (dual) clamp. Gluteal biopsies were obtained before after dual At baseline, WB synthesis breakdown rates similar patients. During clamp, controls had a...
Background Sodium (Na + ) stored in skin and muscle tissue is associated with essential hypertension. magnetic resonance imaging a validated method of quantifying stores Na . In this study, we evaluated patients elevated blood pressure or stage I hypertension response to diuretic therapy low diet. Methods Results double‐blinded, placebo‐controlled trial, systolic 120 139 mm Hg were randomized sodium diet (<2 g sodium), chlorthalidone, spironolactone, placebo for 8 weeks. Muscle using...
Protein energy wasting and systemic inflammation are prevalent in maintenance hemodialysis (MHD) patients. Omega-3 (ω-3) fatty acids have anti-inflammatory properties been shown to improve protein homeostasis. We hypothesized that administration of high-dose (2.9 g/d) ω-3 would be associated with decreased muscle breakdown MHD patients inflammation.This is a substudy from randomized, placebo-controlled study (NCT00655525). Patients were recruited between September 2008 June 2011. Primary...
Abstract No consensus has emerged among different guidelines concerning how many blood pressure (BP) measurements should be performed at office visits in the diagnosis of hypertension. The purpose this study was to examine compatibility various multiple average BP and 24‐h monitoring (ABPM) patients followed up posthoc analysis Cappadocia hypertension cohort. A total 1158 by 207 were examined. results then classified as G1 (average 1 st 2 nd BP), G2 3 rd ), G3 , 4 th G4 2nd, 3rd, 5 G5 all...
Hemodialysis patients are at an increased risk of bleeding due to the platelet dysfunction caused by uremia and use anticoagulants during dialysis. Spontaneous spinal hematoma is a rare disorder as complication in hemodialysis patients. Also it includes secondary coagulopathy, vascular malformation hemorrhagic tumors. Here, we report case 77-year-old woman who presented with cord compression spontaneous epidural associated hemodialysis. When end-stage renal disease patient suffers from back...
Patients with end-stage kidney disease on maintenance hemodialysis commonly develop protein-energy wasting, a syndrome characterized by nutritional and metabolic abnormalities. Nutritional supplementation exercise are recommended to prevent wasting. In 6-mo prospective randomized, open-label, clinical trial, we reported that the combination of resistance does not have an additive effect lean body mass measured dual-energy X-ray absorptiometry. To provide more mechanistic data, performed...
Familial Mediterranean Fever (FMF) is an autosomal recessive disease characterized by periodic attacks of fever and polyserositis. The effects the MEFV genotype differences on clinical picture inflammatory activity have not been well documented. aim this study was to investigate levels conventional inflammation markers, procalcitonin, interleukin levels, TNF-alpha, C5a in patients with FMF who had different genotypes compare them those healthy subjects. consisted 41 (F/M: 23/18), 31 subjects...