A5062826621- Lymphatic System and Diseases
- Body Composition Measurement Techniques
- Body Contouring and Surgery
- Advanced MRI Techniques and Applications
- Sodium Intake and Health
- Sympathectomy and Hyperhidrosis Treatments
- Neuroscience and Neuropharmacology Research
- Myofascial pain diagnosis and treatment
- Lanthanide and Transition Metal Complexes
- MRI in cancer diagnosis
- Nutrition and Health in Aging
- Systemic Sclerosis and Related Diseases
- Diagnosis and Treatment of Venous Diseases
- Cardiovascular Disease and Adiposity
- Thermoregulation and physiological responses
- Molecular Sensors and Ion Detection
- Cerebrospinal fluid and hydrocephalus
- Lymphatic Disorders and Treatments
- Peripheral Artery Disease Management
- Medical Imaging Techniques and Applications
- Blood Pressure and Hypertension Studies
- Dialysis and Renal Disease Management
- Adipokines, Inflammation, and Metabolic Diseases
- Alzheimer's disease research and treatments
- Therapeutic Uses of Natural Elements
Vanderbilt University Medical Center
2017-2025
Vanderbilt University
2017-2025
University of Pennsylvania
2012-2018
Glutamate (Glu) is a major excitatory neurotransmitter in the brain and has been shown to decrease early stages of Alzheimer's disease (AD). Using glutamate chemical (amine) exchange saturation transfer (GluCEST) method, we imaged change [Glu] APP‐PS1 transgenic mouse model AD at high spatial resolution. Compared with wild‐type controls, mice exhibited notable reduction GluCEST contrast (~30%) all areas brain. The was further validated through 1 H MRS. A positive correlation observed between...
To test the hypothesis that tissue sodium and adipose content are elevated in patients with lipedema; if confirmed, this could establish precedence for representing a discriminatory biomarker lipedema.Participants lipedema (n = 10) control 11) volunteers matched biological sex, age, BMI, calf circumference were scanned 3.0-T conventional proton magnetic resonance imaging (MRI). Standardized was quantified skin, subcutaneous (SAT), muscle. Dixon MRI employed to quantify fat water volumes of...
Tauopathies are neurodegenerative disorders characterized by abnormal intracellular aggregates of tau protein, and include Alzheimer's disease, corticobasal degeneration, frontotemporal dementia, traumatic brain injury. Glutamate metabolism is altered in manifesting higher or lower concentrations glutamate, its transporters receptors. Previously, glutamate chemical exchange saturation transfer (GluCEST) magnetic resonance imaging (MRI) demonstrated that levels reduced regions synapse loss...
Background: Lipedema and Dercum's disease (DD) are incompletely characterized adipose tissue diseases, objective measures of profiles needed to aid in differential diagnosis. We hypothesized that fluid properties, quantified as water bioimpedance the upper lower extremities, differ regionally between these conditions. Methods Results: Women (cumulative n = 156) with lipedema (n 110), DD 25), or without an matched for age body mass index early stage patients (i.e., controls 21) were enrolled....
Lipedema is a disease with abnormally increased adipose tissue deposition and distribution. Pain sensations have been described in the clinical evaluation of lipedema, but its etiology remains poorly understood. We hypothesized that pain sensitivity measurements ex vivo quantitation neuronal cell body distribution skin would be lipedema stage-dependent, could, thus, serve to objectively characterize neuropathic lipedema. The was assessed by questionnaire peripheral cutaneous mechanical...
Glutamate chemical exchange saturation transfer (GluCEST) MRI was used to measure metabolic changes in mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) by mapping regional cerebral glutamate. The GluCEST contrast following MPTP treatment correlated 1 H-MR spectroscopy, motor function, and immunohistochemical measures. found be significantly higher the striatum cortex of than controls (p < 0.001), which confirmed localized spectroscopy. Elevated striatal positively...
Abstract Glutamate Chemical Exchange Saturation Transfer (GluCEST) MRI is a recently developed technique to image glutamate. In the present study, we evaluated reproducibility and background contamination GluCEST source of changes in mouse model Parkinson’s disease. Repeated measurements five mice demonstrated an intra-animal coefficient variation (CV) signal be 2.3 ± 1.3% inter-animal CV 3.3 0.3%. Mice were treated with MPTP create localized striatal elevation We found contrast striatum...
Abstract Background Tissue sodium (Na+) content in patients on maintenance hemodialysis (MHD) and peritoneal dialysis (PD) was previously explored using 23Na+ magnetic resonance imaging (23NaMRI). Larger studies would provide a better understanding of Na+ stores as well the factors influencing this accumulation. Methods In cross-sectional study, we quantified calf muscle skin 162 subjects (10 PD, 33 MHD 119 controls) 23NaMRI. Plasma levels interleukin-6 (IL-6) high-sensitivity C-reactive...
Objective The aim of this study is to compare tissue sodium and fat content in the upper lower extremities participants with lipedema versus controls using magnetic resonance imaging (MRI). Methods MRI was performed at 3.0 T females ( n = 15, age 43.2 ± 10.0 years, BMI 30.3 4.4 kg/m 2 ) without 14, 42.8 13.2 28.8 ). Participants were assessed for pain disease stage. Sodium forearm calf quantify regional (TSC, mmol/L). Chemical‐shift–encoded water‐fat identical regions measurement fat/water...
Abstract Background and Aims Sarcopenia, defined as a loss in muscle mass strength, is common patients with advanced chronic kidney disease (CKD), leading to poor outcomes. Intermuscular adipose tissue (IMAT) accumulation associated metabolic functional abnormalities conditions. This study assesses IMAT maintenance hemodialysis (MHD) its association markers physical performance. Methods Results We performed cross-sectional comparing MHD controls. was measured by analyzing the fat-to-muscle...
Patients with chronic kidney disease (CKD) often exhibit ectopic fat accumulation, including intermuscular adipose tissue (IMAT), which is associated metabolic and muscular dysfunctions. This study aimed to evaluate the effects of dulaglutide, a glucagon-like peptide-1 receptor agonist (GLP-1RA), on reducing IMAT improving physical functions in patients CKD stage 3-4. Seven were recruited between April 2022 November 2023. A 12-week dulaglutide (1.5 mg/wk) intervention was conducted pre-and...
Background: National survey data exploring the patient experience with lipedema are lacking. Methods: We conducted national surveys from 2016 to 2022 of women as well female controls. Surveys collected information on symptomatology, pain, and therapies. performed logistic regression comparing symptoms among those versus controls adjusting for age BMI. Results: A total 707 216 completed surveys. Those had a mean 48.6 years BMI 40.9 kg/m 2 . Lipedema symptom onset occurred frequently at...
Background: Lipedema is a distinct adipose disorder from obesity necessitating awareness as well different management approaches to address pain and optimize quality of life (QoL). The purpose this proof-of-principle study evaluate the therapeutic potential physical therapy interventions in women with lipedema. Methods Results: Participants Stage 1-2 lipedema early 0-1 lymphedema (n = 5, age 38.4 ± 13.4 years, body mass index 27.2 4.3 kg/m2) underwent nine visits 6 weeks for symptoms...
Purpose To exploit the long 3.0T relaxation times and low flow velocity of lymphatic fluid to develop a noninvasive lymphangiography sequence evaluate its relevance in patients with lymphedema. Materials Methods A turbo‐spin‐echo (TSE) pulse train echo time (TE effective = 600 msec; shot‐duration 13.2 msec) TSE‐factor (TSE‐factor 90) was developed signal evolution simulated. The method evaluated healthy adults ( n 11) unilateral breast cancer treatment‐related lymphedema (BCRL; 25), subgroup...
Background Sodium (Na + ) stored in skin and muscle tissue is associated with essential hypertension. magnetic resonance imaging a validated method of quantifying stores Na . In this study, we evaluated patients elevated blood pressure or stage I hypertension response to diuretic therapy low diet. Methods Results double‐blinded, placebo‐controlled trial, systolic 120 139 mm Hg were randomized sodium diet (<2 g sodium), chlorthalidone, spironolactone, placebo for 8 weeks. Muscle using...
Background Lipedema exhibits excessive lower‐extremity subcutaneous adipose tissue (SAT) deposition, which is frequently misidentified as obesity until lymphedema presents. MR lymphangiography may have relevance to distinguish lipedema from or lymphedema. Hypothesis Hyperintensity profiles on 3T can identify distinct features consistent with SAT edema in participants lipedema. Study Type Prospective cross‐sectional study. Subjects Participants (48 females, matched for age [mean = 44.8...
Purpose To quantify chemical exchange saturation transfer contrast in upper extremities of participants with lymphedema before and after standardized lymphatic mobilization therapy using correction procedures for B 0 1 heterogeneity, T relaxation. Methods Females (n = 12) without 17) breast cancer treatment‐related (BCRL) matched age body mass index were scanned at 3.0T MRI. efficiency calculated series bilateral axilla ( amplitude 2 µ T, Δ ω ±5.5 ppm, slices 9, spatial resolution 1.8 × 1.47...
Lymphatic vessels are highly responsive to changes in the interstitial environment. Previously, we showed renal lymphatics express Na-K-2Cl cotransporter. Since sodium retention is a hallmark of proteinuric injury, examined whether affects NKCC1 expression and dynamic pumping function lymphatic vessels. Puromycin aminonucleoside (PAN)-injected rats served as model kidney injury. Sodium 23Na/1H-MRI was used measure water content live animals. Renal lymph, which reflects composition,...