A5036601948- Sodium Intake and Health
- Hormonal Regulation and Hypertension
- Eicosanoids and Hypertension Pharmacology
- Nuclear Structure and Function
- Blood Pressure and Hypertension Studies
- Nutritional Studies and Diet
- Diabetes Treatment and Management
- Ion Transport and Channel Regulation
- Essential Oils and Antimicrobial Activity
- Chronic Kidney Disease and Diabetes
- Health disparities and outcomes
- Phytochemistry and biological activities of Ficus species
- Botanical Research and Chemistry
- Cancer Risks and Factors
- Thermoregulation and physiological responses
- Cancer, Lipids, and Metabolism
- Metabolism, Diabetes, and Cancer
- Potassium and Related Disorders
- Diet and metabolism studies
- Nutrition and Health in Aging
- Adipose Tissue and Metabolism
- Neonatal Respiratory Health Research
- Inflammasome and immune disorders
- Liver Disease Diagnosis and Treatment
- Renal function and acid-base balance
Vanderbilt University Medical Center
2020-2024
Vanderbilt University
2020-2023
VA Tennessee Valley Healthcare System
2020-2022
Hacettepe University
2018-2021
University of Michigan
2018
Michigan Medicine
2018
Heidelberg University
2016
Salt sensitivity of blood pressure is an independent predictor cardiovascular morbidity and mortality. The exact mechanism by which salt intake increases risk unknown. We previously found that sodium entry into antigen-presenting cells (APCs) via the amiloride-sensitive epithelial channel EnaC (epithelial channel) leads to formation IsoLGs (isolevuglandins) release proinflammatory cytokines activate T modulate salt-sensitive hypertension. In current study, we hypothesized ENaC-dependent APCs...
BACKGROUND: The mechanisms by which salt increases blood pressure in people with sensitivity remain unclear. Our previous studies found that high sodium enters antigen-presenting cells (APCs) via the epithelial channel and leads to production of isolevuglandins hypertension. In current mechanistic clinical study, we hypothesized channel–dependent isolevuglandin-adduct formation APCs is regulated epoxyeicosatrienoic acids (EETs) salt-sensitive hypertension humans. METHODS: Salt was assessed...
Although statins have served as the cornerstone for pharmacological lowering of lipid levels in atherosclerotic cardiovascular disease (ASCVD) risk reduction, many patients are unable to achieve target doses statin medication due side effects or cholesterol reduction on monotherapy. The landscape lipid-lowering strategies has expanded recent years, with emergence therapies that make use small interfering RNA (siRNA) and antisense oligonucleotides, addition traditional small-molecule agents....
Abstract Background Tissue sodium (Na+) content in patients on maintenance hemodialysis (MHD) and peritoneal dialysis (PD) was previously explored using 23Na+ magnetic resonance imaging (23NaMRI). Larger studies would provide a better understanding of Na+ stores as well the factors influencing this accumulation. Methods In cross-sectional study, we quantified calf muscle skin 162 subjects (10 PD, 33 MHD 119 controls) 23NaMRI. Plasma levels interleukin-6 (IL-6) high-sensitivity C-reactive...
Residing in a disadvantaged neighborhood has been linked to increased mortality. However, the impact of residential segregation and social vulnerability on cause-specific mortality is understudied. Additionally, circulating metabolic correlates sociodemographic environment remain unexplored. Therefore, we examined multiple metrics, i.e., deprivation index (NDI), (RSI), (SVI), with all-cause cardiovascular disease (CVD) cancer-specific metabolites Southern Community Cohort Study (SCCS).
Background Sodium (Na + ) stored in skin and muscle tissue is associated with essential hypertension. magnetic resonance imaging a validated method of quantifying stores Na . In this study, we evaluated patients elevated blood pressure or stage I hypertension response to diuretic therapy low diet. Methods Results double‐blinded, placebo‐controlled trial, systolic 120 139 mm Hg were randomized sodium diet (<2 g sodium), chlorthalidone, spironolactone, placebo for 8 weeks. Muscle using...
High tissue sodium accumulation and intermuscular adipose (IMAT) are associated with aging, type 2 diabetes, chronic kidney disease. In this study, we aim to investigate whether high lower-extremity relates IMAT quantity systemic inflammatory mediators adipocytokines contribute such association.
Cancer survivors are at increased risk of type 2 diabetes, which usually develops from obesity and insulin resistance. Whether diabetes susceptibility is due to shared factors for cancer resistance or directly related its treatment unknown. We investigated effect modification between malignancy body mass index (BMI) as determinants sensitivity in patients with hematologic malignancies controls without cancer. In a cross-sectional study 43 individuals (20 treated malignancies; 23...
Juvenile dermatomyositis (JDM) is an auto-immune muscle disease which presents with skin manifestations and weakness. At least 10% of the patients JDM present acquired lipodystrophy. Laminopathies are caused by mutations in lamin genes cover a wide spectrum diseases including muscular dystrophies The p.T10I LMNA variant associated phenotype generalized lipodystrophy that has also been called atypical progeroid syndrome. A previously healthy female presented bilateral proximal lower extremity...
Salt Sensitivity (SS) of blood pressure (BP) is an independent risk factor for cardiovascular mortality. Sodium (Na+) stored in skin and muscle interstitium. Antigen presenting cells are activated response to elevated extracellular Na+ ENaC-dependent manner resulting formation (isolevuglandin) IsoLG-protein adducts. This leads T-cell activation, release inflammatory cytokines, kidney damage, endothelial dysfunction increase BP. We aimed determine the effect tissue storage immune cell...
Background: Salt sensitivity of blood pressure (SSBP) is an independent risk factor for cardiovascular mortality. However, the mechanisms by which salt exposure affects in SSBP are still unclear. We have shown that under high sodium (Na + ) concentrations, Na enters antigen-presenting cells (APCs) via epithelial channel (ENaC), leads to isolevuglandin (IsoLG) production and hypertension. Baseline %IsoLG+ APC correlates with SSBP. While exact location where APCs activated trigger inflammatory...
Insulin resistance and obesity are prevalent in chronic kidney disease (CKD) patients. The interaction of body mass index (BMI) function across the continuum estimated glomerular filtration rate (eGFR) is unknown.In a cross-sectional study 139 patients, 52 with CKD stages 3 4 87 patients normal eGFR, we measured insulin sensitivity (ISI) using hyperinsulinemic euglycemic clamp homeostasis model assessment (HOMA-IR). We investigated between eGFR BMI their association ISI HOMA-IR linear models...
Introduction: Salt Sensitivity (SS) of blood pressure (BP) is an independent predictor death due to cardiovascular disease, but its pathogenesis poorly understood. Sodium (Na + ) stored in the skin and muscle interstitium. This hyperosmolar Na activates monocytes vitro via oxidative stress with generation isolevuglandin (isoLG) protein adducts that are immunogenic activate adaptive immune system. Methods: Five subjects essential hypertension discontinued all anti-hypertensive therapy for two...
Background: High Na+ stimulates antigen-presenting cells (APCs) in an ENaC dependent manner, with formation of isolevuglandin (isoLG) adducts (neoantigen peptides) that promote T cell activation and salt sensitive (SS) hypertension rodents. Methods: We studied this pathway 9 subjects essential who discontinued anti-hypertensive therapy for 2 weeks. Their SS was assessed by 24-hrs loading (460 mmoL) depletion (10 mmoL/24 hr, plus furosemide 40 mg x 3). Muscle skin Na + were measured at...
Hypercapnia that is often associated with ARDS inhibits alveolar fluid reabsorption by PKC‐dependent mechanisms. Also Hypocapnia seems to reduce lung clearance. In both cases inhibition was internalization of Na/K‐ATPase. a consequence hyperventilation in hypoxia. Hypoxia also clearance decreasing Na/K‐ATPase‐ and Na‐channel dependent transepithelial Na transport. It not known, however, how altered CO2 affects hypoxia‐induced reabsorption. To answer this question we exposed primary rat...