Purpose To develop a new faster and higher quality three‐dimensional (3D) gagCEST MRI technique for reliable quantification of glycosaminoglycan (GAG) present in the human knee cartilages. Methods A magnetization‐prepared 3D gradient echo‐based pulse sequence has been designed to obtain B 0 inhomogeneity, 1 CEST Z‐spectra images. Results The values different compartments cartilage are calculated using newly developed healthy subjects symptomatic degenerated subject. effect acquired...

Tauopathies are neurodegenerative disorders characterized by abnormal intracellular aggregates of tau protein, and include Alzheimer's disease, corticobasal degeneration, frontotemporal dementia, traumatic brain injury. Glutamate metabolism is altered in manifesting higher or lower concentrations glutamate, its transporters receptors. Previously, glutamate chemical exchange saturation transfer (GluCEST) magnetic resonance imaging (MRI) demonstrated that levels reduced regions synapse loss...

Glutamate chemical exchange saturation transfer (GluCEST) MRI was used to measure metabolic changes in mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) by mapping regional cerebral glutamate. The GluCEST contrast following MPTP treatment correlated 1 H-MR spectroscopy, motor function, and immunohistochemical measures. found be significantly higher the striatum cortex of than controls (p < 0.001), which confirmed localized spectroscopy. Elevated striatal positively...

Computational fluid dynamics (CFD) simulations of respiratory airflow have the potential to change clinical assessment regional airway function in health and disease, pulmonary medicine otolaryngology. For example, diseases where multiple sites obstruction occur, such as obstructive sleep apnea (OSA), CFD can identify which contribute most resistance may therefore be candidate for surgery. The main barrier uptake date has been difficulty validating results against a gold standard. Invasive...

Background: Patients who suffer anterior shoulder dislocations are at higher risk of developing glenohumeral arthropathy, but little is known about the initial cartilage damage after a primary dislocation. T1ρ magnetic resonance imaging (MRI) technique that allows quantification proteoglycan content and can detect physiologic changes in articular cartilage. Purpose: This study aimed to establish baseline MRI values for glenoid humeral head cartilage, determine whether traumatic dislocation,...

Abstract Purpose To develop a robust 3D ultrashort‐TE (UTE) protocol that can reproducibly provide high‐quality images, assessed by the ability to yield clinically diagnostic and is suitable for clinical translation. Theory Methods Building on previous work, UTE sampled with Fermat looped orthogonally encoded trajectories (FLORET) was chosen as starting point due its shorter, reasonable scan times. Modifications FLORET implementations included gradient waveform frequency limitations, new...

Purpose To develop a new 3D radial trajectory based on the natural spiral phyllotaxis (SP), with variable anisotropic FOV. Theory &amp; Methods A SP favorable interleaving properties for cardiac imaging has been proposed by Piccini et al ( Magn Reson Med . 2011;66:1049‐1056), which supports FOV fixed anisotropy. However, anisotropy can be inefficient when sampling objects different dimensions. We extend Larson’s method to provide (VASP). Simulations were performed measure distance between...

This work proposes a 2D/3D hybrid inflow MRA technique for fast scanning and high SNR contrast-to-noise (CNR) efficiencies.Localized quadratic (LQ) encoding was combined with sliding-slice spiral acquisition. Inflow MRAs around the circle of Willis carotid bifurcations were collected on four healthy volunteers. Spiral images deblurred without or water-fat separation LQ (ssLQ) out-of-phase (OP) Dixon MRAs, respectively. Results compared to multiple overlapping thin slab acquisitions (MOTSA)...

Purpose To develop a free‐breathing (FB) 2D radial balanced steady‐state free precession cine cardiac MRI method with 100% respiratory gating efficiency using auto‐calibrated motion correction (RAMCO) based on motion‐sensing camera. Methods The signal from camera was recorded during FB retrospectively electrocardiogram triggered acquisition pseudo–tiny‐golden‐angle ordering. With RAMCO, for each the by applying different linear translations, resulting in‐plane image sharpness as criterium....

Abstract Purpose To develop a method that achieves simultaneous brain and neck time‐of‐flight (ToF) magnetic resonance angiography (MRA) within feasible scan timeframes. Methods Localized quadratic (LQ) encoding is efficient for both signal‐to‐noise ratio (SNR) in‐flow enhancement. We proposed spiral multiband LQ to enable intracranial carotid ToF‐MRA single scan. address the venous signal contamination becomes challenge with (MB) ToF, tilt‐optimized non‐saturated excitation (TONE)...

FLORET UTE MRI has been used for many applications including lung, brain, musculoskeletal, and multinuclear imaging. The appeal of the pulse sequence comes from its high SNR sampling efficiencies. With recent improvements minimizing artifacts, high-quality images are obtained routinely. However, acquisition multiple echoes not investigated. Here, we determined feasibility optimal pulse-sequence design multi-echo FLORET. Collecting independently, but interleaved, produces highest quality...

MRI-guided cryoablation is a widely used minimal invasive treatment that uses extreme cold to destroy localized diseased tissues. The cryoneedles are expected introduce little metal artifacts by themselves in the MRI images. However, severe along cryoneedle shaft sometimes observed during guided cryoablations practice, which can not only complicate procedures, but also potentially cause complications and negatively affect outcome. This work demonstrated likely due coupling of RF coils, be...

MR bone imaging has gained more attention for detecting and assessing pathology. In this study, we proposed a new technique consisting of broadband inversion recovery preparation with FLORET UTE Fibonacci interleaved trajectory ordering (FLORET BoneVIEW) to obtain 3D isotropic images within clinically feasible scan time. BoneVIEW great potential help accurate assessment pathology as an alternative CT imaging.

Ultra-short echo time (UTE) imaging enables the depiction of short-T2* tissues and is being increasingly used for generation CT-like bone images. UTE has been recently combined with single-echo Dixon processing to enable separation water fat signals from a single image, but was primarily previously employed in radial stack-of-stars acquisitions prolonged scan durations. The present work combines UTE-Dixon Fermat looped, orthogonally encoded trajectory (FLORET) accelerated simultaneous short...

This study assessed the feasibility of thermometry frozen tissue during MRI-guided cryoablation at 1.5T using a novel 3D spiral staircase UTE sequence (SSCUTE). MRI data SSCUTE were continuously acquired along with temperature measurements several freeze-thaw cycles in ex-vivo porcine specimens. A calibration curve was obtained and corresponding data. MRI-estimated maps generated high accuracy on validation dataset. Our work demonstrated 1.5T, which could be an essential step clinical...

A spiral multiband localized quadratic encoding (LQE) method is proposed to achieve simultaneous brain and neck time of flight MRA within a single 2.5-minute scan. LQE acquisition efficient for both SNR in-flow enhancement. Multi-band enables increased coverage with no increase in scan time, but can introduce venous signal contamination. We propose multi-band approach TONE partial-Fourier slice selection reduce the time-of-flight intracranial carotid arteries.

Purpose An accurate field map is essential to separate fat and water signals in a dual‐echo chemical shift encoded spiral MRI scan. A rapid low‐resolution B 0 prescan usually performed before each exam. Occasional inaccuracy these estimates can lead misclassification of the as well blurring artifacts reconstruction. The present work proposes self‐consistent model evaluate residual offsets according image data improve reconstruction quality facilitate scan efficiency. Theory Methods proposed...

Objective. To develop a respiratory motion-resolved four-dimensional (4D) magnetic resonance imaging (MRI) technique with high-isotropic-resolution (1.1 mm) using 3D radial sampling, camera-based motion sensing, and temporal compressed sensing reconstruction for lung cancer imaging.Approach. Free-breathing half- full-spoke golden-angle acquisitions were performed on eight healthy volunteers patients tumors of varying size. A back-and-forth k-space ordering between consecutive interleaves the...

Conventionally, Cartesian pre-scans are collected over several seconds to create accurate coil sensitivity maps (CSM) for SENSE reconstruction of under-sampled MRI data, with body-coil images used signal normalization. Since body coils have a larger region than phased-array coils, these typically employ very large field-of-view (FOV) avoid aliasing, leading low-resolution CSM and potential small errors in subsequent reconstructions. This abstract proposes new pre-scan sequence using...

FLORET (Fermat looped, orthogonally encoded trajectories) is an efficient center-out 3D spiral trajectory, and it supports ultra-short echo times. In this work, a new trajectory ordering scheme balanced steady-state free precession (FLORET-bSSFP) were developed at 1.5T with inline reconstruction. Simulations, phantom, human lung imaging performed to compare the performance of proposed standard ordering. The minimized artifacts caused by changing gradient moments while improving temporal...

This work aims to develop high-resolution 4D lung MRI with golden-angle 3D radial (kooshball) acquisition and motion-resolved sparse reconstruction. The k-space lines were continuously acquired during free-breathing retrospectively binned multiple respiratory phases respect the signal obtained from a built-in motion-sensing camera. sparsity along motion dimension was exploited using compressed sensing reconstruction suppress artifacts improve SNR. feasibility of half-spoke ultrashort echo...

Camera-based respiratory motion sensing (VitalEye) was successfully used to compute a signal for motion-resolved 4D radial ultrashort echo time (UTE) lung MRI. k-space data were sorted with respect the and binned into 10 different states resolve motion. The signals from VitalEye comparable self-navigators. MRI reconstructions both self-navigators able intensity profiles along lung-liver interface pulmonary vessels demonstrated that they provided sharper image contrast compared motion-averaged images.

Spiral spin-echo and dual sequences have been implemented for knee imaging at 1.5T with in-plane resolution of 0.51 by mm 2 . High-quality proton density-weighted, T2-weighted T1-weighted water fat images various orientations can be obtained using spiral Dixon comparable total scan time as the conventional Cartesian fast (turbo) without Dixon. demonstrated better suppression a 24-67% increase signal-to-noise ratio compared to fat-suppressed reference images.