A5076144606- MRI in cancer diagnosis
- Prostate Cancer Diagnosis and Treatment
- Virus-based gene therapy research
- Prostate Cancer Treatment and Research
- Cancer Research and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Advanced MRI Techniques and Applications
- Radiology practices and education
- CAR-T cell therapy research
- Vascular Malformations and Hemangiomas
- Vascular Malformations Diagnosis and Treatment
- Adrenal and Paraganglionic Tumors
- Radiation Dose and Imaging
- Peripheral Nerve Disorders
- Neuroendocrine Tumor Research Advances
- Neurofibromatosis and Schwannoma Cases
- Medical Imaging and Pathology Studies
- Intraoperative Neuromonitoring and Anesthetic Effects
- Advanced X-ray and CT Imaging
- Innovations in Medical Education
- Ear and Head Tumors
- Ultrasound and Hyperthermia Applications
- Appendicitis Diagnosis and Management
- Health and Medical Research Impacts
- Urologic and reproductive health conditions
Mayo Clinic
2018-2025
Mayo Clinic in Arizona
2023-2025
WinnMed
2021-2025
University College London
2023
Barts Health NHS Trust
2023
Royal Free London NHS Foundation Trust
2023
Royal London Hospital
2023
Whipps Cross University Hospital
2023
Society of Interventional Radiology
2022
National Institutes of Health
1993
Background High variability in prostate MRI quality might reduce accuracy cancer detection. Purpose To prospectively evaluate the of scanners taking part control phase global PRIME (Prostate Imaging Using ± Contrast Enhancement) trial using Prostate Quality (PI-QUAL) standardized scoring system, give recommendations on how to improve protocols, and establish whether could be improved by these recommendations. Materials Methods In prospective clinical (PRIME), for each scanner, centers...
Abstract Immune checkpoint inhibitors have demonstrated modest efficacy as a monotherapy in ovarian cancer. Originally developed to improve of T-cell therapies such immune and adoptive cell transfer, TILT-123 (Ad5/3-E2F-D24-hTNFα-IRES-hIL-2) is serotype chimeric oncolytic adenovirus encoding tumor necrosis factor alpha interleukin-2. Here we report results from phase 1a PROTA, single-arm, multicentre dose escalation trial with pembrolizumab female patients platinum resistant or refractory...
Abstract Background Computed tomography (CT) is routinely used to guide cryoablation procedures. Notably, CT‐guidance provides 3D localization of cryoprobes and can be delineate frozen tissue during ablation. However, metal‐induced artifacts from ablation probes make accurate probe placement challenging degrade the ice ball conspicuity, which in combination could lead undertreatment potentially curable lesions. Purpose In this work, we propose an image‐based neural network (CNN) model for...
Background : Neovascularization induced by basic fibroblast growth factor (basic FGF) or FGF-like cytokines is thought to play a substantial role in the pathogenesis of human immunodeficiency virus (HIV)-associated Kaposi's sarcoma. Pentosan polysulfate has been shown inhibit FGF and dependent tumor both vitro vivo. Moreover, it found sarcoma-derived spindle cells vitro. These observations suggested that pentosan might be worth exploring as potential agent for treatment Purpose The purpose...
<title>Abstract</title> Objectives: Radiologist participation in multidisciplinary tumor board can be time-consuming and demanding, requiring substantial preparation. Anecdotally radiologist is felt to help identify discrepancies previous interpretations; however, there are limited data assessing the actual impact of their review on patient management. This prospective study aims evaluate how reinterpretation outside imaging at hepatobiliary (HBTB) affects diagnosis management patients with...
Abstract Background: Ad5/3-E2F-D24-hTNFa-IRES-hIL-2 (TILT-123) is an oncolytic adenovirus armed with TNFa and IL-2. The cytokine pairing demonstrated superior tumor immunomodulation in preclinical studies. Subsequent studies supported evaluation of TILT-123 PROTA, a phase 1 study combination pembrolizumab platinum resistant or refractory ovarian cancer patients. Biomarker analysis ongoing. Experimental procedures: In this 1a dose escalation trial (NCT05271318), 15 patients received initial...
5555 Background: Platinum-resistant/refractory ovarian cancer presents a significant therapeutic challenge and despite several attempts, immunotherapies have not delivered satisfactory results to be approved. Identifying biomarkers of response novel therapies is crucial for personalizing treatments improving patient outcomes, especially since certain patients do experience long term benefit after the treatment with pembrolizumab igrelimogene litadenorepvec (TILT-123; an oncolytic adenovirus...
Abstract Background A limitation of approved oncolytic viruses is their requirement for intratumoral (i.t.) injection. TILT-123 (igrelimogene litadenorepvec, Ad5/3-E2F-D24-hTNFα-IRES-hIL-2) a chimeric adenovirus suitable intravenous (i.v.) delivery due to its capsid modification and dual selectivity devices. It armed with tumor necrosis alpha interleukin-2 promoting T-cell activation lymphocyte trafficking tumors, thereby enhancing the antitumor immune response. Here, we present findings...
The objective of this study was to evaluate the role adrenal venous sampling (AVS) in guiding management patients with corticotropin (ACTH)-independent glucocorticoid secretory autonomy and bilateral masses.A cohort 25 underwent AVS surgical management.Cortisol measured from veins (AVs) inferior vena cava (IVC). AV/IVC cortisol ratio lateralization (CLR) (dominant AV concentration divided by nondominant concentration) were calculated. Posthoc receiver-operating characteristic curves...
Abstract Background and study aims Management of malignant gastrointestinal obstruction (MGIO) is more challenging in the presence peritoneal carcinomatosis (PC). Outcomes data to guide management MGIO with PC are lacking. We aimed compare clinical outcomes adverse events between endoscopic surgical palliation identify predictors stent success patients PC. Patients methods Consecutive inpatients 2000 2018 who underwent palliative surgery or enteral stenting were included. Clinical was...
2658 Background: Immune checkpoint inhibitors provide limited benefit in patients with immunologically cold tumors, characterized by a lack of T cells. This creates niche for cell-inducing agents such as TILT-123 (igrelimogene litadenorepvec, Ad5/3-E2F-D24-hTNFa-IRES-hIL2). While the 5/3 chimeric oncolytic adenovirus platform prompts potent immunogenic capacity per se, this virus has been armed TNFa and IL-2 selected based on their ability to activate attract cells into tumors. capsid...
Acute appendiceal diverticulitis is a difficult prospective diagnosis due to both its rarity and clinical overlap with other ileocecal diseases, such as acute appendicitis. Few preoperative radiological images of have been presented in the literature. We report case initially diagnosed outpatient ultrasound confirmed contrast-enhanced computed tomography an 85-year-old male who right lower quadrant pain. Appendiceal often overlooked diagnosis, given association neoplasms relatively high rate...