A5054200475- Bladder and Urothelial Cancer Treatments
- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Urinary and Genital Oncology Studies
- BRCA gene mutations in cancer
- Hormonal and reproductive studies
- Cancer, Lipids, and Metabolism
- Urinary Bladder and Prostate Research
- Kidney Stones and Urolithiasis Treatments
- Urologic and reproductive health conditions
- Metabolism, Diabetes, and Cancer
- Pediatric Urology and Nephrology Studies
- Urological Disorders and Treatments
- Glycosylation and Glycoproteins Research
- Urinary Tract Infections Management
- Radiomics and Machine Learning in Medical Imaging
- Renal cell carcinoma treatment
- Cancer Risks and Factors
- Galectins and Cancer Biology
- Ureteral procedures and complications
- MRI in cancer diagnosis
- Colorectal Cancer Screening and Detection
- Genital Health and Disease
- Cancer Research and Treatments
- Sexual Differentiation and Disorders
Rabin Medical Center
2016-2025
Tel Aviv University
2014-2023
Tel Aviv Sourasky Medical Center
2000-2023
Whipps Cross University Hospital
2023
Barts Health NHS Trust
2023
University College London
2023
Royal Free London NHS Foundation Trust
2023
Royal London Hospital
2023
Misgav Ladach
2017-2020
Princess Margaret Cancer Centre
2011-2016
Purpose To evaluate the association between cumulative duration of metformin use after prostate cancer (PC) diagnosis and all-cause PC-specific mortality among patients with diabetes. Patients Methods We used a population-based retrospective cohort design. Data were obtained from several Ontario health care administrative databases. Within men older than age 66 years incident diabetes who subsequently developed PC, we examined effect antidiabetic medication exposure PC on mortality. Crude...
We report magnetic resonance imaging findings among unselected men with low risk prostate cancer before active surveillance.We prospectively enrolled grade, risk, localized cancer. All patients underwent multiparametric endorectal coil and were offered confirmatory biopsy within 1 year of imaging. The primary outcome was the impact on identifying who reclassified by as no longer fulfilling surveillance criteria. further identified clinical parameters associated reclassification. cohort...
No AccessJournal of UrologyAdult Urology1 Dec 2019Cardiovascular Morbidity in a Randomized Trial Comparing GnRH Agonist and Antagonist among Patients with Advanced Prostate Cancer Preexisting Cardiovascular DiseaseThis article is commented on by the following:Editorial Comment David Margel, Avivit Peer, Yaara Ber, Liat Shavit-Grievink, Tzlil Tabachnik, Sivan Sela, Guy Witberg, Jack Baniel, Daniel Kedar, Wilhelmina C. M. Duivenvoorden, Eli Rosenbaum, Jehonathan H. Pinthus MargelDavid Margel...
Background High variability in prostate MRI quality might reduce accuracy cancer detection. Purpose To prospectively evaluate the of scanners taking part control phase global PRIME (Prostate Imaging Using ± Contrast Enhancement) trial using Prostate Quality (PI-QUAL) standardized scoring system, give recommendations on how to improve protocols, and establish whether could be improved by these recommendations. Materials Methods In prospective clinical (PRIME), for each scanner, centers...
Androgen deprivation therapy is the cornerstone of treatment for patients with advanced prostate cancer. Meta-analysis small, oncology-focused trials suggest gonadotropin-releasing hormone (GnRH) antagonists may be associated fewer adverse cardiovascular outcomes compared GnRH agonists.
BackgroundMetformin is commonly prescribed to treat type 2 diabetes. Recent evidence suggests that it may possess antitumoral properties. The aim of this study was test the association between metformin use and risk prostate cancer its grade among men with
Introduction: The use of a ureteral access sheath (UAS) may provide significant advantages, particularly, in the treatment large renal stone burden. However, some patients, passage UAS up ureter is impossible. We prospectively evaluated ability to insert 14F and analyzed possible predictors for an effective insertion. Patients Methods: In bicenter prospective study, 248 consecutive patients undergoing ureteroscopy retrograde intrarenal surgery (RIRS) were recruited. each case, we attempted...
Male-carriers of BRCA1/2 gene mutations have an increased risk prostate cancer (PCa) with a more aggressive phenotype. Current screening-guidelines suggest the use prostate-specific antigen (PSA) only among BRCA2 carriers. Female carriers extensive guidelines that include imaging. Our objective was to test prevalence PCa BRCA and examine screening strategies, using PSA multiparametric magnetic resonance imaging (mpMRI).We recruited men aged 40-70 years germline no prior history biopsy. All...
Background Gallium 68 (68Ga) prostate-specific membrane antigen (PSMA) PET/MRI may improve detection of clinically significant prostate cancer (CSPC). Purpose To compare the sensitivity and specificity 68Ga-PSMA with multiparametric MRI for detecting CSPC. Materials Methods Men specific levels 2.5-20 ng/mL prospectively underwent PET/MRI, including sequences, between June 2019 March 2020. Imaging was evaluated independently by two radiologists using Prostate Reporting Data System (PI-RADS)...
The aim of this study was to describe a single institution's experience with transanal endoscopic microsurgery in patients benign and malignant rectal tumors.Between January 1992 April 1998, 75 mean follow up 38 months, underwent excision (46) or (29) tumors, located 3 18 cm from the dentate line.A total 46 (6.5 percent) tumors conversion radical surgery owing tumor size. During follow-up period, recurrence observed four (9 patients, three whom were managed by repeat microsurgery, whereas...
To compare two different biopsy devices for upper tract urothelial carcinoma (UTUC) and evaluate the pathologic result obtained by these devices.From January 2008 to December 2010, 414 ureteroscopies were performed 504 biopsies taken evaluation of UTUC. Two compared: 2.4F stainless steel flat wire basket 3F cup forceps. The effect device on obtaining an adequate specimen was evaluated using univariate multivariate binary logistic regression analysis. We also investigated whether tumor grade...
Background and Purpose: Open stone surgery nowdays is rare. However, some patients who are treated today have in the past undergone open nephrolithotomy. The aim of this study was to determine possible impact nephrolithotomy on efficacy morbidity subsequent percutaneous (PCNL). Patients Methods: We reviewed files all 167 undergoing PCNL at our institution between December 2000 2003. same surgeon performed procedures. compared 21 after kidney with other PCNL. groups did not differ terms age...
WHAT'S KNOWN ON THE SUBJECT? AND WHAT DOES STUDY ADD?: Recurrence and progression prediction in urothelial cancer is currently based on clinical pathological factors: tumour grade, stage, number of lesions, size, previous recurrence rate, presence concomitant carcinoma situ. These factors are not specific enough to predict ∼50% patients diagnosed as high risk fact do progress within 3 years. Patient follow-up both expensive unpleasant (frequent invasive cystoscopies). Molecular biomarkers,...