A5089735195- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Urologic and reproductive health conditions
- Radiomics and Machine Learning in Medical Imaging
- MRI in cancer diagnosis
- Urological Disorders and Treatments
- Bladder and Urothelial Cancer Treatments
- Sports injuries and prevention
- Tendon Structure and Treatment
- Urinary Bladder and Prostate Research
- Cancer, Hypoxia, and Metabolism
- Pelvic floor disorders treatments
- Shoulder Injury and Treatment
- Ovarian cancer diagnosis and treatment
- Urinary Tract Infections Management
Gentofte Hospital
2017-2024
University of Copenhagen
2024
Whipps Cross University Hospital
2023
University College London
2023
Barts Health NHS Trust
2023
Royal London Hospital
2023
Royal Free London NHS Foundation Trust
2023
Addenbrooke's Hospital
2017
Herlev Hospital
2013-2017
Frederiksberg Hospital
2012
<h3>Importance</h3> Multiparametric magnetic resonance imaging (MRI) enhances detection and risk stratification for significant prostate cancer but is time-consuming (approximately 40 minutes) expensive. Rapid simpler 15-minute) biparametric MRI (bpMRI) using fewer scan sequences could be implemented as a triage test on larger scale before performing biopsies. <h3>Objectives</h3> To assess the diagnostic accuracy negative predictive value (NPV) of novel bpMRI method in biopsy-naive men...
Purpose To evaluate the correlation between apparent diffusion coefficient measurements (ADCtumor and ADCratio) Gleason score from radical prostatectomy specimens. Materials Methods Seventy-one patients with clinically localized prostate cancer scheduled for were prospectively enrolled. Multiparametric magnetic resonance imaging (MRI) was performed prior to mean ADC values both cancerous (ADCtumor) benign (ADCbenign) tissue measured calculate ADCratio divided by ADCbenign). The correlated...
Background High variability in prostate MRI quality might reduce accuracy cancer detection. Purpose To prospectively evaluate the of scanners taking part control phase global PRIME (Prostate Imaging Using ± Contrast Enhancement) trial using Prostate Quality (PI-QUAL) standardized scoring system, give recommendations on how to improve protocols, and establish whether could be improved by these recommendations. Materials Methods In prospective clinical (PRIME), for each scanner, centers...
Background: Color Doppler ultrasound is widely used to examine intratendinous flow in individuals with overuse tendon problems, but the association between color and pain still unclear. Hypothesis: Intratendinous present associated badminton players, increase during a season. Study Design: Cohort study (prognosis); Level of evidence, 2. Methods: Ninety-five semiprofessional players were included at tournament start All interviewed regarding pain. The anterior knee tendons Achilles studied....
Abstract Purpose To automatically assess the aggressiveness of prostate cancer ( PC a) lesions using zonal‐specific image features extracted from diffusion weighted imaging DWI ) and T2W MRI . Methods Region interest was (peripheral zone) (transitional zone anterior fibromuscular stroma) around center 112 PCa 99 patients. Image histogram texture features, 38 in total, were used together with a k‐nearest neighbor classifier to classify into their respective prognostic Grade Group GG (proposed...
The purpose of this study was to investigate the detection rate prostate cancer (PCa) by multiparametric magnetic resonance imaging-targeted biopsies (mp-MRI-bx) in patients with prior negative transrectal ultrasound biopsy (TRUS-bx) sessions without previous experience this.Eighty-three TRUS-bx scheduled for repeated due persistent suspicion PCa were prospectively enrolled. mp-MRI performed before and all lesions scored according Prostate Imaging Reporting Data System (PI-RADS) Likert...
Background: To develop an international, multi-site nomogram for side-specific prediction of extraprostatic extension (EPE) prostate cancer based on clinical, biopsy, and magnetic resonance imaging- (MRI) derived data. Methods: Ten institutions from the USA Europe contributed clinical biopsy MRI variables consecutive patients who underwent prostatectomy. A logistic regression model was used to a predicting EPE prostatectomy specimens. The performance statistical evaluated by bootstrap...
Background Multiparametric magnetic resonance imaging (mpMRI) can improve detection of clinically significant prostate cancer (csPCa). Purpose To compare mpMRI score subgroups to systematic transrectal ultrasound-guided biopsies (TRUS bx ) and prostate-specific antigen (PSA)-based findings for csPCa in men undergoing repeat biopsies. Material Methods MpMRI was performed prior re-biopsy 289 prospectively enrolled patients. All underwent TRUS followed by targeted (MRI TB any mpMRI-identified...
We assessed the risk of significant prostate cancer being detected after low suspicion magnetic resonance imaging or suspicious with benign guided biopsies in men prior negative systematic biopsies.Overall 289 prospectively enrolled underwent followed by repeat and targeted any lesions at baseline. A total 194 patients target were suitable for this study. Those who baseline least 3 years. calculated predictive values ruling out cancer, defined as core Gleason score greater than 6, more 2...
BackgroundActive surveillance of men with prostate cancer relies on accurate risk assessments because it aims to avoid or delay invasive therapies and reduce overtreatment. PurposeTo compare the diagnostic performance pre-biopsy biparametric magnetic resonance imaging (MRI) confirmatory multiparametric MRI in selecting for active surveillance. Material MethodsThe study population included biopsy-naïve clinical suspicion undergoing followed by combined (standard plus targeted) biopsies. Men...
Abstract Purpose To compare two strategies: Prostate-specific antigen density (PSAd) and lesion volume measurement in ruling out significant prostate cancer (sPCa) men with equivocal Prostate Imaging Reporting Data System (PI-RADS) category 3 index lesions on biparametric magnetic resonance imaging. Methods In total, 130 from our database had PI-RADS scores of 3. was measured using the ellipsoid method, accordance version 2.1 criteria. Index volumes were also ellipsoidal formula...
We assessed the 5-year risk of being diagnosed with significant prostate cancer following a low-suspicion biparametric magnetic resonance imaging result.The study population was derived from prospective database used to assess diagnostic accuracy for detection in 1020 biopsy-naïve men. Significant defined as any core Gleason grade group ≥3 or maximum cancerous length greater than 50% 2. A secondary definition also included: ≥2. Of men, 305 had result (Prostate Imaging Reporting and Data...
Only limited data have been published on the diagnostic accuracy of combining biparametric (bp) magnetic resonance imaging (MRI) and prostate-specific antigen density (PSAd) to rule out biopsies.The purpose is assess 2-year risk being diagnosed with sPCa following strategy avoiding immediate biopsies in men non-suspicious bp MRIs a PSAd <0.15 ng/mL2.Two hundred biopsy-naïve clinical suspicion PCa underwent pre-biopsy MRI from March July 2019. Of these, 109 had Prostate Imaging Reporting Data...
Advances in for magnetic resonance imaging (MRI)-guided transperineal biopsy (TPBx) techniques have facilitated outpatient prostate biopsies under local anaesthesia to lower postbiopsy infection rates. However, there is debate regarding antibiotic prophylaxis because of concerns resistance and interactions. Our objective was assess the transition from office-based transrectal TPBx performed without despite potential risk factors infectious complications. We conducted a prospective assessment...
To assess the level of disease progression at confirmatory staging biopsies after 1 year active surveillance (AS) and compare detection rate significant prostate cancers (PCas) in patients who underwent pre-biopsy biparametric magnetic resonance imaging (bpMRI) before first set diagnostic transrectal ultrasonography-guided (TRUS-bx) with did not undergo bpMRI.Comparison two patient groups enrolled AS. Patients Group A (n = 127) bpMRI followed by TRUS-bx ± targeted biopsies. B were AS based...