A5065180058- Cervical Cancer and HPV Research
- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Bladder and Urothelial Cancer Treatments
- Genital Health and Disease
- Radiomics and Machine Learning in Medical Imaging
- Reproductive tract infections research
- Urinary and Genital Oncology Studies
- AI in cancer detection
- Urologic and reproductive health conditions
- MRI in cancer diagnosis
- Colorectal Cancer Screening and Detection
- Breast Lesions and Carcinomas
- Radiology practices and education
- Ovarian cancer diagnosis and treatment
- Genetic factors in colorectal cancer
- Hedgehog Signaling Pathway Studies
- Urinary Tract Infections Management
- Infectious Diseases and Mycology
- Molecular Biology Techniques and Applications
- Pancreatic and Hepatic Oncology Research
- Health Policy Implementation Science
- Public Health Policies and Education
- Salivary Gland Tumors Diagnosis and Treatment
- Syphilis Diagnosis and Treatment
Yale University
2016-2025
Yale New Haven Hospital
2012-2022
Friends University
2020
University of Rochester Medical Center
2020
East Tennessee State University
2020
University of California San Francisco Medical Center
2020
Fairfield University
2020
University of New Haven
2016-2019
Johns Hopkins University
2000-2016
Intermountain Medical Center
2016
Prostate cancer is a leading cause of morbidity and mortality for adult males in the US. The diagnosis prostate carcinoma usually made on core needle biopsies obtained through transrectal approach. These may account significant portion pathologists' workload, yet variability experience expertise, as well fatigue pathologist adversely affect reliability detection. Machine-learning algorithms are increasingly being developed tools to aid improve diagnostic accuracy anatomic pathology. Paige...
Persistent high-risk human papillomavirus (hrHPV) infection is essential for the development of cervical cancer and its precursor lesions. High-risk HPV testing has a higher sensitivity than cytology does detecting epithelial However, large study from single institution showed 31% patients with invasive had negative baseline hrHPV within 5 years preceding diagnosis.To investigate limitation in cancer.Cases 2012 histologic diagnosis carcinoma were retrieved multiple institutions. From those...
Abstract Purpose: We report the results of a randomized phase II trial imiquimod, topical immune-response modulator versus imiquimod plus 9-valent human papillomavirus (HPV) vaccine (9vHPV) clinical surveillance in cervical intraepithelial neoplasia (CIN2/3) patients. Patients and Methods: randomly allocated 133 patients with untreated CIN2/3 equal proportions to 4-month treatment self-applied vaginal suppositories containing (Arm B) or 9vHPV C) A). The main outcome was efficacy, defined as...
Prostatic adenocarcinoma resembling benign hyperplastic glands architecturally is a recently recognized entity. In the only prior study on this entity, 100 needle biopsies were studied and two contained carcinoma with pseudohyperplastic features, which occupied small percentage of cancer. The current investigates histologic attributes prostatic biopsy simple prostatectomy in regions represent majority authors reviewed outside cases received consultation by one (J.I.E.) surgical pathology...
Recent studies have shown that human papillomavirus (HPV) is associated with a certain subset of head and neck squamous cell carcinoma (HNSCC)-namely, those arising in the oropharynx. The objective this study to determine efficacy, detection, genotype high-risk (HR) HPV using Roche cobas 4800 system (Roche Molecular System, Pleasanton, CA).Forty-two fine-needle aspirate (FNA) specimens from 37 patients cervical (n = 36) or mediastinal 5) lymphadenopathy left parapharyngeal mass =1) were...
Abstract Background Partnering with community leaders, we sought to address ongoing diagnostic testing needs in underserved neighborhoods and evaluate whether a saliva-based mobile program could help overcome barriers for uninsured low-income individuals. This is critical as many lack primary care provider, cannot access reliable health information, or have limited financial resources.Figure 3.Layout of the lab-in-a-van.(a) Mobile van top view; (b) interior work bench side view. Source:...
Abstract Mollaret's meningitis (MM) is a rare disease of benign nature characterized by recurrent episodes aseptic meningitis. Cerebrospinal fluid (CSF) examination remains the sole diagnostic modality. Eighteen CSF samples from 14 patients were studied along with clinical data. Specimens prepared cytocentrifugation and Millipore filtration stained Diff‐Quik Papanicolaou stains. Eight men six women, an age range 17–74 yr (mean 37 yr). Most common presentation was headaches photophobia...
Context All Food and Drug Administration–approved methods in the United States for human papillomavirus testing including Hybrid Capture 2 assay Roche cobas test are approved cytology specimens collected into ThinPrep media but not SurePath solution. Objective To compare performance of tests detection high-risk using both preparations as part a validation study. Design One thousand three hundred seventy-one liquid-based samples, 1122 249 specimens, were tested DNA assay. For cases with...
To compare the Affirm VPIII molecular test (Becton Dickinson, Burlington, NC) with morphologic identification used in routine Papanicolaou (Pap) screening detection and of Candida species, Trichomonas vaginalis, Gardnerella we identified 431 cases a concomitant Pap assay performed from archives large academic institution. The study population consisted women ranging age 17 to 79 years (mean median ages, 33 31 years, respectively). With test, 60 patients (13.9%) were found have bacterial...
Background: To develop an international, multi-site nomogram for side-specific prediction of extraprostatic extension (EPE) prostate cancer based on clinical, biopsy, and magnetic resonance imaging- (MRI) derived data. Methods: Ten institutions from the USA Europe contributed clinical biopsy MRI variables consecutive patients who underwent prostatectomy. A logistic regression model was used to a predicting EPE prostatectomy specimens. The performance statistical evaluated by bootstrap...
BACKGROUND Human papillomavirus (HPV) DNA testing for high-risk types after Papanicolaou (Pap) smear interpretations of atypical squamous cells undetermined significance (ASCUS) is a sensitive method identifying women who harbor underlying high-grade intraepithelial lesions (HSIL). To the authors' knowledge, application HPV to ASCUS smears in routine practice with comparison probabilistic and interpretive models cytologic reporting has not been reported. METHODS was performed reflexively on...
An accurate biomarker for the follow-up of women positive human papillomavirus type 16 (HPV16) DNA may improve efficiency cervical cancer prevention. Previously, we analyzed all 113 HPV16 CpGs in cytology samples and discovered differential methylation at different stages premalignancy. In current study, identified a consisting panel 12 CpG sites E5, L2, L1 open reading frames, tested whether it fulfilled three necessary conditions prospective biomarker. A total 33 from North American West...
Although to our knowledge the significance of denuded urothelium in bladder biopsies has not been studied previously, it is thought be a problem because benign urothelial cells are cohesive and expected shed into urine. We correlated pertinent clinical features patients with and/or specific pathological biopsy specimens patient outcome regard lesions help predict subsequent likelihood diagnosing carcinoma nondiagnostic biopsy.We 51 from 44 which average extent epithelial denudation was...
Studies examining the effects of increased workload on performance individual cytotechnologists are limited. Using FocalPoint GS, 3 was evaluated. The study consisted phases. In phase I, were asked to screen at their usual pace. II, as fast possible without feeling that quality work diminished. III, least 15% more than daily from II. Productivity by decreasing percentage cases underwent full manual review (from 38% 19%) and time spent each slide 5.5 min 3.7 min). Overall, total abnormal rate...
Our cytology laboratory, like many others, is under pressure to improve quality and provide test results faster while decreasing costs. We sought address these issues by introducing new technology lean principles.To determine the combined impact of FocalPoint Guided Screener (GS) Imaging System (BD Diagnostics-TriPath, Burlington, North Carolina) manufacturing principles on turnaround time (TAT) productivity gynecologic operation.We established a baseline measure TAT for Papanicolaou tests....
Abstract Background: Recently, the Food and Drug Administration approved use of location‐guided imaging system FocalPoint GS (FPGS), on SurePath Papanicolaou (Pap) tests for primary screening. The objective current study was to evaluate impact FPGS following: distribution diagnostic categories; rate high‐risk human papillomavirus (HR‐HPV)–positive ASC‐US cases; quality control (QC) data before after implementation. Methods: A search laboratory information performed identify all Pap processed...
BACKGROUND Pigmented neoplasms are extremely rare in the pancreas, and, when black pigment is identified, it often suggests diagnosis of metastatic melanoma. The authors describe two patients with pigmented “black” neuroendocrine tumors pancreas. One patient had an incidental (0.5 cm) finding, and second a well-demarcated, 4.5-cm mass identified by computerized tomography that was consistent islet cell tumor. METHODS were resected surgically studied light microscopy using hematoxylin eosin...
Abstract BACKGROUND The role of testing for high‐risk human papillomavirus (HR HPV) when triaging women with a cytologic diagnosis low‐grade squamous intraepithelial lesion (LSIL) has not been well established. objective the current study was to correlate status HR HPV incidence cervical neoplasia 2 and more severe lesions (CIN 2+) on tissue follow‐up in LSIL. METHODS A total 1046 LSIL were identified database large teaching hospital within 12‐month period. performed using Hybrid Capture...