A5048913816- Cervical Cancer and HPV Research
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer and Skin Lesions
- Neuroendocrine Tumor Research Advances
- Medical Imaging and Pathology Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Lung Cancer Research Studies
- AI in cancer detection
- Thyroid Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Breast Lesions and Carcinomas
- Infectious Diseases and Mycology
- Viral-associated cancers and disorders
- Ovarian cancer diagnosis and treatment
- Molecular Biology Techniques and Applications
- Lung Cancer Diagnosis and Treatment
- Genital Health and Disease
- Lymphoma Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Breast Cancer Treatment Studies
- Tumors and Oncological Cases
- Fungal Infections and Studies
- Radiomics and Machine Learning in Medical Imaging
- Soft tissue tumor case studies
- Cancer, Stress, Anesthesia, and Immune Response
Mayo Clinic
2020-2024
Mayo Clinic in Arizona
2020-2023
WinnMed
2021-2022
Baylor College of Medicine
2013-2021
University of Mississippi Medical Center
2021
Jackson Memorial Hospital
2021
University of Miami
2021
Henry Ford Health System
2021
University of California, San Francisco
2021
John Wiley & Sons (United States)
2006-2020
Most prior studies of primary diagnosis in surgical pathology using whole slide imaging (WSI) versus microscopy have focused on specific organ systems or included relatively few cases. The objective this study was to demonstrate that WSI is noninferior for pathology. A blinded randomized noninferiority conducted across the entire range cases (biopsies and resections, including hematoxylin eosin, immunohistochemistry, special stains) from 4 institutions original sign-out (baseline diagnosis)...
// Hannah Wang 1, 2 , Jessica Altemus 1 Farshad Niazi Holly Green 4 Benjamin C. Calhoun 5 Charles Sturgis Stephen R. Grobmyer 2, 4, 6, 8 and Charis Eng 3, 7, Genomic Medicine Institute, Lerner Research Cleveland Clinic, Cleveland, OH, USA Clinic College of Medicine, 3 Taussig Cancer Surgical Oncology, Digestive Disease Surgery Department Anatomic Pathology, Robert J. Tomsich Pathology Laboratory 6 Comprehensive Breast Program, 7 Genetics Genome Sciences, Case Western Reserve University...
Abstract Understanding alteration of cell morphology in disease has been hampered by the diffraction-limited resolution optical microscopy (>200 nm). We recently developed an technique, partial wave spectroscopy (PWS), which is capable quantifying statistical properties structure at nanoscale. Here we use PWS to show for first time increase disorder strength nanoscale architecture not only tumor cells but also microscopically normal-appearing outside tumor. Although genetic and...
Abstract Transforming growth factor-β (TGF-β) is thought to play a role in the pathobiological progression of ovarian cancer because this peptide hormone overexpressed tissue, plasma, and peritoneal fluid. In current study, we investigated TGF-β/Smad3 pathway metastasis by regulation an epithelial-to-mesenchymal transition. When cells were cultured on plastic, TGF-β1, TGF-β2, TGF-β3 induced pro–matrix metalloproteinase (MMP) secretion, loss cell-cell junctions, down-regulation E-cadherin,...
Granulomatous mastitis is an uncommon inflammatory disease that typically presents with painful breast lesions. Recent publications have brought to light a specific subset of granulomatous patients distinct histological pattern termed, "cystic neutrophilic mastitis" (CNGM). Although many cases lobular been thought be idiopathic, this rare has linked infections Corynebacterium species. Herein, cohort CNGM from large, tertiary care, North-American, academic medical center presented....
Background The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) offers a six‐tiered diagnostic scheme thyroid Fine Needle Aspiration (FNA): Benign, Atypia of Undetermined Significance/Follicular Lesion Significance (AUS/FLUS), suspicious follicular neoplasm, malignancy, malignant, and unsatisfactory with an aim to standardize criteria. Reported rate AUS/FLUS category in the literature has varied from 3% 20.5%. Methods this study was assess interobserver variability among...
Persistent high-risk human papillomavirus (hrHPV) infection is essential for the development of cervical cancer and its precursor lesions. High-risk HPV testing has a higher sensitivity than cytology does detecting epithelial However, large study from single institution showed 31% patients with invasive had negative baseline hrHPV within 5 years preceding diagnosis.To investigate limitation in cancer.Cases 2012 histologic diagnosis carcinoma were retrieved multiple institutions. From those...
Breast cancer risk estimates for atypical lesions are based primarily on case-control studies of patients with open biopsies. The authors report the cumulative breast incidence after a core biopsy diagnosis hyperplasia (ductal or lobular) lobular carcinoma in situ.A cohort study central pathology review was conducted 393 who had diagnoses and situ from 1995 through 2010. Follow-up available 255 264 (97%) at median 87 months (range, 3-236 months).There were 212 (54%) not upgraded excision no...
Abstract Purpose: Pancreatic cancer remains one of the most deadly cancers and carries a dismal 5-year survival rate <5%. Therefore, there is urgent need to develop highly accurate minimally invasive (e.g., without instrumentation pancreatic duct given high complications) method detection. Our group has developed collection novel light-scattering technologies that provide unprecedented quantitative assessment nanoscale architecture epithelium. We propose approach predict through...
Pelvic pain is a common presenting ailment in women often linked to ovulation, endometriosis, early pregnancy, ovarian cancer, and cysts. Clear differential diagnosis for each condition caused by these varied etiologies difficult may slow the delivery of therapy that, case could be fatal. Ovarian endosalpingiosis, pelvic typified presence cystic glandular structures lined benign tubal/salpingeal epithelium, also associated with women. The exact cellular antecedents epithelial are not known,...
Background The eighth edition of the American Joint Committee on Cancer staging manual (AJCC8) added depth invasion to definition pathologic T stage (pT). In current study, authors assess pT migration and prognostic performance updated compare it with other clinicopathologic variables in patients early squamous cell carcinoma oral tongue (OTSCC; tumors measuring ≤4 cm) histologically benign lymph nodes (pN0). Methods A multi‐institutional cohort OTSCC was restaged as per AJCC8. Primary...
Ocular and periocular hematolymphoid diseases are a diverse group of lesions affecting various soft tissue structures within the orbital cavity. Lymphoid proliferations in particular among most commonly diagnosed entities pathology. When noninvasive techniques fail to confirm or rule out suspicion neoplasia, fine-needle aspiration (FNA) may be use establishing diagnosis reliable, timely, cost-effective safe manner. From 1986 1999, 79 orbital/ocular needle biopsies were conducted by staff...
One blinded observer (C.D.S.) retrospectively reviewed 76 previously diagnosed and biopsy-confirmed malignant bronchial brush wash specimens, 46 non-small cell 30 small carcinomas, obtained from 55 patients. Each case was scored for the presence or absence of 36 standard criteria (architectural, cytoplasmic, nuclear). Logistic regression analysis used to determine which were most useful separating lesions. Although no single criterion displayed 100% sensitivity specificity cancer, univariate...
Results of fine-needle aspiration (FNA) solid-tissue neoplasms arising in the periocular glands are infrequently reported literature. To our knowledge, no previous series relating to this topic exist. Neoplastic processes that arise semiconfined area orbit behave as space-occupying lesions. Such lesions can exert significant pressure on globe, be responsible for altered vision, and result proptosis. When noninvasive techniques fail confirm or rule out suspicion a neoplastic lacrimal adnexal...
Abstract Identification of molecular aberrations in premalignant human mammary epithelial cells (hMEC), the precursors for breast cancers, is a central goal cancer biology. Recent studies implicated expression cyclooxygenase 2 (COX-2) as marker to identify precursor cancer. In this study, we analyzed COX-2 preselection and postselection hMEC observed similar levels both cells. Interestingly, immortalization using various methods leads dramatic decrease expression. Similar immortal cells,...
Elevated activin A levels in serum, cyst fluid, and peritoneal fluid of ovarian cancer patients suggest a role for this peptide hormone disease development. We hypothesize that plays tumor biology, analyzed activin-mediated pro-oncogenic signaling vitro the expression pathway molecules vivo. Activin regulation Akt GSK, effects repressing activities these (with pharmacological inhibitors) on cellular proliferation were assessed cell line, OVCA429. activated Akt, which phosphorylated GSK...
Background Although cervical cancer is an AIDS-defining condition, infection with human immunodeficiency virus (HIV) may only modestly increase the risk of cancer. There a paucity information regarding factors that influence natural history papillomavirus (HPV) in HIV-infected women. We examined associated intraepithelial neoplasia grade 3 or (CIN3+) Rwandan women infected both HIV and HPV (HIV+/HPV+). Methods In 2005, 710 HIV+ ≥25 years enrolled observational cohort study; 476 (67%) tested...