A5055091241- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Cerebrovascular and Carotid Artery Diseases
- MRI in cancer diagnosis
- Functional Brain Connectivity Studies
- Hemoglobinopathies and Related Disorders
- Cerebrospinal fluid and hydrocephalus
- Acute Ischemic Stroke Management
- Moyamoya disease diagnosis and treatment
- Lymphatic System and Diseases
- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Intracranial Aneurysms: Treatment and Complications
- Fetal and Pediatric Neurological Disorders
- Bone and Joint Diseases
- Lanthanide and Transition Metal Complexes
- Traumatic Brain Injury and Neurovascular Disturbances
- Atomic and Subatomic Physics Research
- Cardiovascular Health and Disease Prevention
- Iron Metabolism and Disorders
- Neurological Complications and Syndromes
- Helminth infection and control
- Dementia and Cognitive Impairment Research
- Spinal Dysraphism and Malformations
- Cardiac Imaging and Diagnostics
Vanderbilt University Medical Center
2016-2025
Vanderbilt University
2016-2025
Institute of Behavioral Sciences
2025
Vanderbilt Health
2023
SickKids Foundation
2019
Hospital for Sick Children
2019
Neurological Surgery
2017-2018
University of Milan
2018
McLean Hospital
2017
Imaging Center
2017
We report the case of a 79-year-old woman with Alzheimer's disease who participated in Phase III randomized controlled trial called CLARITY-AD testing experimental drug lecanemab. She was to placebo group and subsequently enrolled an open-label extension which guaranteed she received active drug. After third biweekly infusion, suffered seizure characterized by speech arrest generalized convulsion. Magnetic resonance imaging revealed had multifocal swelling marked increase number cerebral...
Abstract The accuracy of cerebral blood flow (CBF) estimates from arterial spin labeling (ASL) is affected by the presence both gray matter (GM) and white within any voxel. Recently a partial volume (PV) correction method for ASL has been demonstrated (Asllani et al. Magn Reson Med 2008; 60:1362–1371), where PV were used with local linear regression to separate GM signal. Here new multi‐inversion time proposed that exploits spatially regularized kinetic curve model analysis. different...
Chemical exchange saturation transfer (CEST)-derived, pH-weighted, amide proton (APT) MRI has shown promise in animal studies for the prediction of infarction risk ischemic tissue. Here, APT was translated to patients with acute stroke (1-24 h post-symptom onset), and assessments contrast, perfusion, diffusion, disability final infarct volume (23-92 days post-stroke) are reported. Healthy volunteers (n = 5) 10) onset symptoms (0-4 h, n 7; uncertain <24 3) were scanned diffusion-...
To compare diffusion tensor imaging (DTI) measurements at ultra high field strength (7 Tesla [T]) in human volunteers with DTI performed 1.5 and 3 Tesla.The signal to noise ratio (SNR) the uncertainty fitted parameters fractional anisotropy primary eigenvector are assessed tractography based regions of interest, measured nine 1.5T, 3T, 7T clinically available hardware configurations.An increase SNR is observed on system compared or 3T system. The larger than expected from alone, indicating...
Abstract Background and Purpose Clinically, Parkinson's disease ( PD ) presents with asymmetric motor symptoms. The left nigrostriatal system appears more susceptible to early degeneration than the right, a left‐lateralized pattern of neuropathological changes is also described in several neurodegenerative conditions, including Alzheimer's disease, frontotemporal dementia, Huntington's disease. In this study, we evaluated hemispheric differences estimated rates atrophy large,...
Sickle cell anaemia is a monogenetic disorder with high incidence of stroke. While stroke screening procedures exist for children sickle anaemia, no accepted assessing risk in adults. The purpose this study to use novel magnetic resonance imaging methods evaluate physiological relationships between oxygen extraction fraction, cerebral blood flow, and clinical markers cerebrovascular impairment adults anaemia. specific goal determine what extent elevated fraction may be uniquely present...
Purpose Despite the generally accepted view that aerobic exercise can have positive effects on brain health, few studies measured responses to over a short time span. The purpose of this study was examine impact within one hour single bout perfusion and neuronal activation. Methods Healthy adults (n = 16; age range: 20–35 yrs) were scanned using Magnetic Resonance Imaging (MRI) before after 20 minutes at 70% their age-predicted maximal heart rate. Pseudo-continuous arterial spin labeling...
To test the hypothesis that tissue sodium and adipose content are elevated in patients with lipedema; if confirmed, this could establish precedence for representing a discriminatory biomarker lipedema.Participants lipedema (n = 10) control 11) volunteers matched biological sex, age, BMI, calf circumference were scanned 3.0-T conventional proton magnetic resonance imaging (MRI). Standardized was quantified skin, subcutaneous (SAT), muscle. Dixon MRI employed to quantify fat water volumes of...
Abstract Background The choroid plexus functions as the blood-cerebrospinal fluid (CSF) barrier, plays an important role in CSF production and circulation, has gained increased attention light of recent elucidation circulation dysfunction neurodegenerative conditions. However, methods for routinely quantifying volume are suboptimal require technical improvements validation. Here, we propose three deep learning models that can segment from commonly-acquired anatomical MRI data report...
Previously we demonstrated that 90% of infarcts in children with sickle cell anemia occur the border zone regions cerebral blood flow (CBF). We tested hypothesis adults disease (SCD) have silent (SCIs) regions, a secondary older age and traditional stroke risk factors would be associated infarct occurrence outside zones.
Vascular space occupancy (VASO)-dependent functional MRI (fMRI) is a blood-nulling technique capable of generating microvascular cerebral blood volume (CBV)-weighted images. It shown that at high magnetic field (3.0T) and spatial resolution (1.89 × 1.89 3 mm3), the VASO signal changes are too large (6–7%) to originate from CBV effects alone. Additional contributions investigated theoretically experimentally as function parameters (TR TE), well signal-to-noise ratio, (SNR) resolution. First,...
Abstract Arterial spin labeling (ASL) provides a noninvasive method to measure brain perfusion and is becoming an increasingly viable alternative more invasive MR methods due improvements in acquisition, such as the use of three‐dimensional GRASE readout. A potential source error ASL measurements signal arising from intravascular blood that destined for distal tissue. This typically suppressed using diffusion gradients many sequences. However, several problems exist with this approach,...
The development of neuroimaging methods to characterize flow-metabolism coupling is crucial for understanding mechanisms that subserve oxygen delivery. Functional magnetic resonance imaging (fMRI) using blood-oxygenation-level-dependent (BOLD) contrast reflects composite changes in cerebral blood volume (CBV), flow (CBF), and the metabolic rate consumption (CMRO 2 ). However, it difficult separate these parameters from BOLD signal, thereby hampering MR-based studies. Here, a novel,...
Hippocampal hyperactivity has been proposed as a biomarker in schizophrenia. However, there is debate whether the CA1 or CA2/3 subfield selectively affected. We studied 15 schizophrenia patients and matched healthy control subjects with 3T steady state, gadolinium-enhanced, absolute cerebral blood volume (CBV) maps, perpendicular to long axis of hippocampus. The subfields hippocampal formation (subiculum, CA1, CA2/3, hilus/dentate gyrus) were manually segmented establish CBV values....
Blood oxygenation level-dependent fMRI contrast depends on the volume and of blood flowing through circulatory system. The effects image intensity depend temporally arrival within a voxel, signal can be monitored during time course such flow. It has been previously shown that passage global endogenous variations in tracked as passes brain by determining strength peak lag their cross-correlation with data. By manipulating composition using transient hypercarbia hyperoxia, we induce much...
Purpose To evaluate the correlation between angiographic measures of Moyamoya disease and tissue‐level impairment from measurements tissue perfusion cerebrovascular reactivity (CVR). Materials Methods The relationship perfusion‐weighted arterial spin labeling (ASL) hypercarbic blood oxygenation‐level dependent (BOLD) CVR time‐to‐peak (TTP) were compared with angiographically measured risk factors, including circulation time (ACT) modified Suzuki Score (mSS) in patients (n = 15) disease....
A promising method for identifying hemodynamic impairment that may serve as a biomarker stroke risk in patients with intracranial stenosis is cerebrovascular reactivity (CVR) mapping using noninvasive MRI. Here, abilities to measure CVR safely the clinic hypercarbic hyperoxic (carbogen) gas challenges, which increase oxygen delivery tissue, are investigated.In sequence structural and angiographic imaging, blood oxygenation level-dependent carbogen-induced scans were performed symptomatic...
To assess cross-sectionally whether lower cardiac index relates to resting cerebral blood flow (CBF) and cerebrovascular reactivity (CVR) among older adults.Vanderbilt Memory & Aging Project participants free of stroke, dementia, heart failure were studied (n = 314, age 73 ± 7 years, 59% male, 39% with mild cognitive impairment). Cardiac (liters per minute meter squared) was quantified from echocardiography. Resting CBF (milliliters 100 grams minute) hypercapnia-induced CVR pseudo-continuous...
Abstract To address the global burden of sickle cell disease (SCD) and need for novel therapies, American Society Hematology partnered with US Food Drug Administration to engage work 7 panels clinicians, investigators, patients develop consensus recommendations clinical trial end points. The conducted their through literature reviews, assessment available evidence, expert judgment focusing on points related to: patient-reported outcomes (PROs), pain (non-PROs), brain, end-organ...