A5077295286- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- MRI in cancer diagnosis
- Cerebrovascular and Carotid Artery Diseases
- Functional Brain Connectivity Studies
- Atomic and Subatomic Physics Research
- Medical Imaging Techniques and Applications
- Cardiac Imaging and Diagnostics
- Long-Term Effects of COVID-19
- Advanced NMR Techniques and Applications
- Acute Ischemic Stroke Management
- NMR spectroscopy and applications
- Lanthanide and Transition Metal Complexes
- Cancer, Hypoxia, and Metabolism
- Cardiovascular Health and Disease Prevention
- Electron Spin Resonance Studies
- Glioma Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Intensive Care Unit Cognitive Disorders
- Diet and metabolism studies
- Optical Imaging and Spectroscopy Techniques
- Ultrasound and Hyperthermia Applications
- COVID-19 and Mental Health
John Radcliffe Hospital
2013-2025
University of Oxford
2016-2025
Wellcome Centre for Integrative Neuroimaging
2015-2024
Imperial College London
2022-2024
Oxford University Hospitals NHS Trust
2024
University of Chicago
2023
Oxford Health NHS Foundation Trust
2023
National Institute for Health Research
2023
NIHR Leicester Biomedical Research Centre
2021-2023
University of Leicester
2021-2023
To assess intrinsic properties of water diffusion in normal human brain by using quantitative parameters derived from the tensor, D, which are insensitive to patient orientation.Maps principal diffusivities Trace(D), and anisotropy indices were calculated eight healthy adults 31 multisection, interleaved echo-planar diffusion-weighted images acquired about 25 minutes.No statistically significant differences Trace(D) (approximately 2,100 x 10(-6) mm2/sec) found within parenchyma, except...
Abstract A method for detecting significant and regionally specific correlations between sensory input the brain's physiological response, as measured with functional magnetic resonance imaging (MRI), is presented in this paper. The involves testing hemodynamic response after convolving an estimate of function. This obtained without reference to any assumed input. To lend approach statistical validity, it brought into framework parametric mapping by using a measure cross‐correlations that...
A method is described for the correction of geometric distortions occurring in echo planar images. The are caused large part by static magnetic field inhomogeneities, leading to pixel shifts, particularly phase encode direction. By characterizing inhomogeneities from a map, image can be unwarped so that accurate alignment conventionally collected images made. algorithm perform unwarping described, and results at 1.5 4 Tesla shown.
BackgroundThe medium-term effects of Coronavirus disease (COVID-19) on organ health, exercise capacity, cognition, quality life and mental health are poorly understood.MethodsFifty-eight COVID-19 patients post-hospital discharge 30 age, sex, body mass index comorbidity-matched controls were enrolled for multiorgan (brain, lungs, heart, liver kidneys) magnetic resonance imaging (MRI), spirometry, six-minute walk test, cardiopulmonary test (CPET), life, cognitive assessments.FindingsAt 2–3...
Cerebral organization during sentence processing in English and American Sign Language (ASL) was characterized by employing functional magnetic resonance imaging (fMRI) at 4 T. Effects of deafness, age language acquisition, bilingualism were assessed comparing results from ( i ) normally hearing, monolingual, native speakers English, ii congenitally, genetically deaf, signers ASL who learned late through the visual modality, iii hearing bilinguals English. All groups, their language, or ASL,...
Abstract Multiple sclerosis is still regarded primarily as a disease of the white matter. However, recent evidence suggests that there may be significant involvement gray Here, we have used magnetic resonance imaging and spectroscopy in vivo histopathology postmortem to estimate thalamic neuronal loss patients with multiple sclerosis. Our results show can substantial (30–35% reduction). We conclude neurodegenerative pathology make major contribution genesis symptoms
The effects of photic stimulation on the visual cortex human brain were studied by means gradient-echo echo-planar imaging (EPI). Whole-body 4 and 1.5 T MRI systems, equipped with a small z axis head gradient coil, used. Variations image intensity up to 28% at T, 7% observed in primary cortex, corresponding an increase blood oxygenation regions increased neural activity. larger are due importance susceptibility difference between deoxygenated oxygenated high fields.
To introduce a new toolkit for simulation and processing of magnetic resonance spectroscopy (MRS) data, to demonstrate some its novel features.The FID appliance (FID-A) is an open-source, MATLAB-based software MRS data. The designed specifically data with multiple dimensions (eg, radiofrequency channels, averages, spectral editing dimensions). It equipped functions importing in the formats most major MRI vendors Siemens, Philips, GE, Agilent) exporting into several common packages LCModel,...
Continuous theta burst stimulation (cTBS) is a novel transcranial technique that causes significant inhibition of synaptic transmission for <or=1 h when applied over the primary motor cortex (M1) in humans. Here we use magnetic resonance spectroscopy to define mechanisms mediating this by noninvasively measuring local changes cortical concentrations gamma-aminobutyric acid (GABA) and glutamate/glutamine (Glx). cTBS left M1 led an increase GABA compared with at control site without change...
Purpose Frequency and phase drifts are a common problem in the acquisition of vivo magnetic resonance spectroscopy (MRS) data. If not accounted for, frequency will result artifactual broadening spectral peaks, distortion lineshapes, reduction signal‐to‐noise ratio (SNR). We present herein new method for estimating correcting MRS Methods used simple fitting each average to reference scan (often first series) time domain through adjustment terms. Due similarity with image registration, this is...
There is consensus that autism spectrum disorder (ASD) accompanied by differences in neuroanatomy. However, the neural substrates of ASD during adulthood, as well how these relate to behavioral variation, remain poorly understood.To identify brain regions and systems associated with a large, well-characterized sample adults.Multicenter case-control design using quantitative magnetic resonance imaging.Medical Research Council UK Autism Imaging Multicentre Study (MRC AIMS), sites comprising...
Magnetic resonance diffusion imaging is potentially an important tool for the noninvasive characterization of normal and pathological tissue. The technique, however, prone to a number artifacts that can severely affect its ability provide clinically useful information. In this study, problem eddy current-induced geometric distortions occur in images acquired with echo planar sequences was addressed. These produce computed maps parameters are caused by misalignments individual...
Abstract „Vascular”︁ artifacts can have substantial effects on human cerebral blood flow values calculated by using arterial spin tagging approaches. One vascular artifact arises from the contribution of „tagged”︁ water spins to observed change in brain MR signal. This be reduced if large bipolar gradients are used „crush”︁ signal moving spins. A second relaxation during transit plane capillary exchange site imaging slice. corrected times measured „dynamic”︁ The mean time sites a gray matter...
The degree to which the process involved in visual perception and imagery share a common neuroanatomical substrate is unclear. Physiological evidence for localization of early pathways would have important bearing on current theories processing. A magnetic resonance imaging technique sensitive regional changes blood oxygenation was used obtain functional activation maps human cortex. During recall stimulus, focal increases signal related flow were detected V1 V2 cortex five seven subjects....
OBJECTIVE: The authors used magnetic resonance spectroscopy (MRS) to assess the effect of acute administration selective serotonin reuptake inhibitor (SSRI) citalopram on cortical levels γ-aminobutyric acid (GABA). METHOD: Ten healthy volunteers received either intravenous (10 mg) or saline in a randomized, double-blind, crossover design. occipital GABA/creatine ratio was measured with proton MR spectral editing technique. RESULTS: In comparison saline, produced mean increase 35% relative...
Abstract In this study, changes in blood oxygenation and volume were monitored while monolingual right-handed subjects read English sentences. Our results confirm the role of left peri-sylvian cortex language processing. Interestingly, individual subject analyses reveal a pattern activation characterized by several small, limited patches rather than few large, anatomically well-circumscribed centers. Between-subject lateralized active classical areas including Broca's area, Wernicke's...