A5024738343- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Long-Term Effects of COVID-19
- Cerebrovascular and Carotid Artery Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Acute Ischemic Stroke Management
- Intensive Care Unit Cognitive Disorders
- COVID-19 and Mental Health
- MRI in cancer diagnosis
- Infrared Thermography in Medicine
- Thermoregulation and physiological responses
- Infectious Encephalopathies and Encephalitis
- Health, Environment, Cognitive Aging
- Machine Learning in Healthcare
- Cardiovascular Health and Disease Prevention
- Thermal Regulation in Medicine
- COVID-19 and healthcare impacts
- Optical Imaging and Spectroscopy Techniques
- Epilepsy research and treatment
University of Nottingham
2020-2025
Queen's Medical Centre
2021-2024
Nottingham Biomedical Research Centre
2021-2024
University of Oxford
2013-2021
Mansfield University
2021
Wellcome Centre for Integrative Neuroimaging
2021
BackgroundThe medium-term effects of Coronavirus disease (COVID-19) on organ health, exercise capacity, cognition, quality life and mental health are poorly understood.MethodsFifty-eight COVID-19 patients post-hospital discharge 30 age, sex, body mass index comorbidity-matched controls were enrolled for multiorgan (brain, lungs, heart, liver kidneys) magnetic resonance imaging (MRI), spirometry, six-minute walk test, cardiopulmonary test (CPET), life, cognitive assessments.FindingsAt 2–3...
Abstract Background The medium-term effects of Coronavirus disease (COVID-19) on multiple organ health, exercise capacity, cognition, quality life and mental health are poorly understood. Methods Fifty-eight COVID-19 patients post-hospital discharge 30 comorbidity-matched controls were prospectively enrolled for multiorgan (brain, lungs, heart, liver kidneys) magnetic resonance imaging (MRI), spirometry, six-minute walk test, cardiopulmonary test (CPET), life, cognitive assessments. Findings...
Abstract Arterial Spin Labelling (ASL) MRI is now an established non-invasive method to quantify cerebral blood flow and increasingly being used in a variety of neuroimaging applications. With standard ASL acquisition protocols widely available, there growing interest advanced options that offer added quantitative precision information about haemodynamics beyond perfusion. In this article, we introduce the BASIL toolbox, research tool for analysis data included within FMRIB Software Library...
Abstract The Human Connectome Project Lifespan studies cover the development (5–21) and ageing (36–100+) phases of life. Arterial spin labelling (ASL) was included in imaging protocol, resulting one largest datasets collected to date high spatial resolution multiple delay ASL covering 3,000 subjects. human connectome project (HCP)-ASL minimal processing pipeline developed specifically for this dataset pre-process image data produce perfusion estimates both volumetric surface template space,...
SARS-CoV-2 infection has been shown to damage multiple organs, including the brain. Multiorgan MRI can provide further insight on repercussions of COVID-19 organ health but requires a balance between richness and quality data acquisition total scan duration. We adapted UK Biobank brain protocol produce high-quality images while being suitable as part post-COVID-19 multiorgan exam. The analysis pipeline, also from Biobank, includes new imaging-derived phenotypes (IDPs) designed assess...
Objective: Ischaemic stroke is a leading cause of death and disability. Autoregulation collateral blood flow through the circle Willis both play role in preventing tissue infarction. To investigate interaction these mechanisms one-dimensional steady-state model cerebral arterial network was created. Methods: Structural variants that present particular risk were recreated by using coupled with: 1) physiological autoregulation; 2) one wherein vascular bed modeled as passive resistance....
Arterial spin labeling (ASL) is a widely used contrast-free MRI method for assessing cerebral blood flow (CBF). Despite the generally adopted ASL acquisition guidelines, there still wide variability in analysis. We explored this through ISMRM-OSIPI ASL-MRI Challenge, aiming to establish best practices more reproducible
Abstract The Human Connectome Project Lifespan studies cover the Development (5-21) and Aging (36-100+) phases of life. Arterial spin labelling (ASL) was included in imaging protocol, resulting one largest datasets collected to-date high spatial resolution multiple delay ASL covering 3,000 subjects. HCP-ASL minimal processing pipeline developed specifically for this dataset to pre-process image data produce perfusion estimates both volumetric surface template space. Applied whole dataset,...
Stroke is a major cause of death and disability worldwide. Therapeutic hypothermia potentially useful neuroprotective treatment. A mathematical model brain metabolism during stroke extended here to simulate the effect on cell survival. Temperature decreases were set reduce chemical reaction rates slow diffusion through ion channels according Q10 rule. Heat delivery tissues was depend metabolic heat generation rate perfusion. Two cooling methods, scalp vascular, simulated approximate...
Dopamine has direct and complex vasoactive effects on cerebral circulation. Catechol-O-methyltransferase (COMT) regulates cortical dopamine, its activity can be influenced both genetically pharmacologically. COMT influences the functional connectivity of PFC at rest, as well during task performance, determined using blood oxygen level-dependent (BOLD) fMRI. However, perfusion have been relatively unexplored. Here, 76 healthy males, homozygous for Val158Met polymorphism, were administered...
ABSTRACT SARS-CoV-2 infection has been shown to damage multiple organs, including the brain. Multiorgan MRI can provide further insight on repercussions of COVID-19 organ health but requires a balance between richness and quality data acquisition total scan duration. We adapted UK Biobank brain protocol produce high-quality images while being suitable as part post-COVID-19 multiorgan exam. The analysis pipeline, also from Biobank, includes new imaging-derived phenotypes (IDPs) designed...
The arterial spin labelling (ASL) data from the Human Connectome Project (HCP) Lifespan studies can provide a source of unusually high-resolution hemodynamic measures >2500 individuals with ages 5-21 and 37-100+. This work presents summary minimal ASL processing pipeline used to pre-processed calibrated perfusion arrival time measurements for cortical surface subcortical volumes, these individuals. accounts slice-wise image intensity variations resulting simultaneous multi-slice...
Simultaneous multi-slice (SMS) acquisitions enable higher resolutions to be achieved for arterial spin labelling (ASL) images. However, SMS can introduce a banded pattern of intensity within the This reduces quality motion estimation as algorithm aligns bands in preference brain structures. We Gaussian Process model that used correct banding multiple post-labelling delay ASL data, which should improve correction. demonstrate its effectiveness on 10 subjects from Human Connectome Project...