A5084523764- Glioma Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Radiopharmaceutical Chemistry and Applications
- RNA modifications and cancer
- Advanced MRI Techniques and Applications
- MRI in cancer diagnosis
- Cancer, Hypoxia, and Metabolism
- Hemoglobinopathies and Related Disorders
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Atomic and Subatomic Physics Research
- Bone and Joint Diseases
- Mitochondrial Function and Pathology
- Nanoplatforms for cancer theranostics
- Acute Ischemic Stroke Management
- Barrier Structure and Function Studies
- Nanoparticle-Based Drug Delivery
- interferon and immune responses
- Lung Cancer Treatments and Mutations
- Gaussian Processes and Bayesian Inference
- Blood groups and transfusion
- Cardiac Imaging and Diagnostics
- Statistical Methods and Inference
- Radiomics and Machine Learning in Medical Imaging
- Cerebrovascular and Carotid Artery Diseases
University of Nottingham
2011-2024
University of Oxford
2017-2023
Nottingham Biomedical Research Centre
2022
Queen's Medical Centre
2022
Hospital for Sick Children
2014-2019
Abstract Purpose: Tumor hypoxia fuels an aggressive tumor phenotype and confers resistance to anticancer treatments. We conducted a clinical trial determine whether the antimalarial drug atovaquone, known mitochondrial inhibitor, reduces in non–small cell lung cancer (NSCLC). Patients Methods: with NSCLC scheduled for surgery were recruited sequentially into two cohorts: cohort 1 received oral atovaquone at standard dose of 750 mg twice daily, while 2 did not. Primary imaging endpoint was...
Overt ischaemic stroke is one of the most devastating complications in children with sickle cell disease (SCD). The compensatory response to anaemia SCD includes an increase cerebral blood flow (CBF) by accessing cerebrovascular dilatory reserve. Exhaustion reserve secondary anaemic stress may lead ischaemia. purpose this study was investigate CBF and reactivity (CVR) using magnetic resonance imaging (MRI) correlate these haematological markers anaemia. Baseline measured arterial spin...
Key points Cerebrovascular reactivity (CVR) reflects the vasodilatory reserve of cerebral resistance vessels. Normal development in children is associated with significant changes blood pressure, flow (CBF) and oxygen metabolism. Therefore, it stands to reason that CVR will also undergo during this period. The study acquired magnetic resonance imaging measures CBF healthy young adults trace their age. We found two phases, increasing age until mid‐teens, followed by a decrease. Baseline...
Abstract Purpose: Despite optimal local therapy, tumor cell invasion into normal brain parenchyma frequently results in recurrence patients with solid tumors. The aim of this study was to determine whether microvascular inflammation can be targeted better delineate the tumor-brain interface through vascular adhesion molecule-1 (VCAM-1)-targeted MRI. Experimental Design: Intracerebral xenograft rat models MDA231Br-GFP (breast cancer) metastasis and U87MG (glioblastoma) were used...
Arterial spin labeling (ASL) is a widely used contrast-free MRI method for assessing cerebral blood flow (CBF). Despite the generally adopted ASL acquisition guidelines, there still wide variability in analysis. We explored this through ISMRM-OSIPI ASL-MRI Challenge, aiming to establish best practices more reproducible
Relative cerebral blood volume (rCBV) is the most widely used parameter derived from DSC perfusion MR imaging for predicting brain tumor aggressiveness. However, accurate rCBV estimation challenging in enhancing glioma, because of contrast agent extravasation through a disrupted blood-brain barrier (BBB), and even nonenhancing glioma with an intact BBB, due to elevated steady-state concentration vasculature after first passage. In this study thorough investigation effects two different...
The measurement of venous cerebral blood oxygenation (Yv) has potential applications in the study patient groups where oxygen extraction and/or metabolism are compromised. It is also useful for fMRI studies to assess stimulus-induced changes Yv, particularly since basal Yv partially accounts inter-subject variation haemodynamic response a stimulus. A range MRI-based methods measuring have been developed recently. Here, we use method based on change phase MR image arising from field...
Abstract Introduction Transcranial Doppler ultrasonography ( TCD ) is a clinical tool for stratifying ischemic stroke risk by identifying abnormal elevations in blood flow velocity BFV the middle cerebral artery MCA ). However, not effective at screening subtle neurologic injury such as silent infarcts. To better understand this disparity, we compared measures of with tissue‐level CBF using arterial spin‐labeling MRI children and without sickle cell disease, correlated these measurements...
The relationship between venous blood oxygenation and change in transverse relaxation rate (ΔR2*) plays a key role calibrated BOLD fMRI. This relationship, defined by the parameter β, has previously been determined using theoretical simulations experimental measures. However, these earlier studies have confounded cerebral volume (CBV) response to functional tasks. study used double-echo gradient echo EPI scheme conjunction with graded isocapnic hyperoxic sequence assess quantitatively...
The OSIPI ASL MRI Challenge is an initiative of the community aiming to characterize variability CBF quantification arising from different pipelines. goal this challenge establish best practice in data processing, understand sources variability, make analysis more reproducible, and enable fair comparison between studies. Here, we analyzed 3 submitted entries 7 teams registered challenge. preliminary results showed pipelines based programming languages tools, leading important quantitative...
Supplementary Figure from VCAM-1–targeted MRI Improves Detection of the Tumor-brain Interface
Supplementary Figure from VCAM-1–targeted MRI Improves Detection of the Tumor-brain Interface
Supplementary Figure from VCAM-1–targeted MRI Improves Detection of the Tumor-brain Interface
Supplementary Figure from VCAM-1–targeted MRI Improves Detection of the Tumor-brain Interface
Supplementary Figure from VCAM-1–targeted MRI Improves Detection of the Tumor-brain Interface