A5080585279- Hemoglobinopathies and Related Disorders
- Advanced MRI Techniques and Applications
- MRI in cancer diagnosis
- Bone and Joint Diseases
- Acute Ischemic Stroke Management
- Molecular Spectroscopy and Structure
- Advanced Neuroimaging Techniques and Applications
- Inorganic Fluorides and Related Compounds
- Cerebrovascular and Carotid Artery Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Boron Compounds in Chemistry
- Chemical Reactions and Mechanisms
- Organoboron and organosilicon chemistry
- Atmospheric Ozone and Climate
- Cardiovascular Health and Disease Prevention
- Ocular Surface and Contact Lens
- Chemical Reactions and Isotopes
- Fibroblast Growth Factor Research
- Cerebral Palsy and Movement Disorders
- Iron Metabolism and Disorders
- Various Chemistry Research Topics
- Analytical Chemistry and Chromatography
- Vestibular and auditory disorders
- Prenatal Screening and Diagnostics
- Neonatal and fetal brain pathology
Ehime University
2020
Hospital for Sick Children
2010-2019
University College London
2010
SickKids Foundation
2010
Great Ormond Street Hospital
2010
<h3>BACKGROUND AND PURPOSE:</h3> There is a critical need for reliable and clinically feasible imaging technique that can enable prognostication selection revascularization surgery in children with Moyamoya disease. Blood oxygen level–dependent MR assessment of cerebrovascular reactivity, using voluntary breath-hold hypercapnic challenge, one such simple technique. However, its repeatability reliability disease are unknown. The current study sought to address this limitation. <h3>MATERIALS...
Overt ischaemic stroke is one of the most devastating complications in children with sickle cell disease (SCD). The compensatory response to anaemia SCD includes an increase cerebral blood flow (CBF) by accessing cerebrovascular dilatory reserve. Exhaustion reserve secondary anaemic stress may lead ischaemia. purpose this study was investigate CBF and reactivity (CVR) using magnetic resonance imaging (MRI) correlate these haematological markers anaemia. Baseline measured arterial spin...
Key points Cerebrovascular reactivity (CVR) reflects the vasodilatory reserve of cerebral resistance vessels. Normal development in children is associated with significant changes blood pressure, flow (CBF) and oxygen metabolism. Therefore, it stands to reason that CVR will also undergo during this period. The study acquired magnetic resonance imaging measures CBF healthy young adults trace their age. We found two phases, increasing age until mid‐teens, followed by a decrease. Baseline...
Cerebrovascular reactivity (CVR) measures the ability of cerebral blood vessels to change their diameter and, hence, capacity regulate regional flow in brain. High resolution quantitative maps CVR can be produced using blood-oxygen level-dependent (BOLD) magnetic resonance imaging (MRI) combination with a carbon dioxide stimulus, and these have become useful tool clinical evaluation cerebrovascular disorders. However, conventional analysis does not fully characterize BOLD response stimulus...
To evaluate the reproducibility of cerebrovascular reactivity (CVR) measurements acquired in children using magnetic resonance imaging (MRI) combination with a computer-controlled carbon dioxide (CO2 ) stimulus.Ten healthy (age 16.1 ± 1.6 years) underwent CVR on 3T scanner blood-oxygen level-dependent (BOLD) MRI sequence. Targeted hypercapnia was induced during CO2 gas challenge delivered specialized sequencer (RespirAct). A total four BOLD scans were performed over 2 separate days to test...
Purpose: To compare measurements of blood flow velocity (BFV) and BFV changes in the middle cerebral arteries (MCA) acquired from phase contrast magnetic resonance angiography (PCMRA) transcranial Doppler ultrasound (TCD) during controlled manipulation end‐tidal partial pressure carbon dioxide (P et CO 2 ). Materials Methods: In vivo TCD PCMRA data M1 segment MCA nine healthy adult volunteers were precise targeting P induced by a computer‐controlled gas delivery system. spectra processed...
We have evaluated carotid gamma imaging using 111Indium-labelled platelets in the diagnosis of artery disease and measured accumulation labelled on endarterectomy specimens. Autologous 111In were injected 25 patients with TIA. Gamma images then taken daily independently interpreted by two observers. Carotid was performed 11 allowing measurement radioactivity operative specimen. These results compared to findings angiography Doppler spectral analysis. All specimens accumulated most active...
Summary Sickle cell anaemia (SCA) is a devastating genetic blood disorder leading to chronic anaemia, impaired cerebrovascular dilatory capacity and cerebral infarctions. Our aim was assess the relationship between microstructural properties of white matter (WM) both reactivity (CVR) flow, as well effects hydroxycarbamide on these relationships. results demonstrate that mean CVR increased in hydroxycarbamide‐treated patients compared untreated patients. Moreover, SCA had skew kurtosis...
Abstract Introduction Transcranial Doppler ultrasonography ( TCD ) is a clinical tool for stratifying ischemic stroke risk by identifying abnormal elevations in blood flow velocity BFV the middle cerebral artery MCA ). However, not effective at screening subtle neurologic injury such as silent infarcts. To better understand this disparity, we compared measures of with tissue‐level CBF using arterial spin‐labeling MRI children and without sickle cell disease, correlated these measurements...
The transferability of the sigma enlarging bridge (SEB) function from Lennard-Jones (LJ) monatomic solute to LJ diatomic one is studied under utilization solvent-solvent correlation func...
The ocular counter-roll (OCR) reflex generates compensatory torsional eye movements during static head tilt. OCR gain is defined as the ratio of change in position to position. Previous reports have varied considerably among normal subjects, perhaps due use different targets and viewing distances. This study compared gains well-controlled (simple vs complex, near far viewing) healthy subjects (n=60; age 10–62). Two visual stimuli were used: a simple target consisting central fixation cross...