A5019279914- Neonatal and fetal brain pathology
- Moyamoya disease diagnosis and treatment
- Cerebrovascular and Carotid Artery Diseases
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Intracranial Aneurysms: Treatment and Complications
- Cerebral Palsy and Movement Disorders
- Acute Ischemic Stroke Management
- Neurological Complications and Syndromes
- Gallbladder and Bile Duct Disorders
- Advanced MRI Techniques and Applications
- Neural and Behavioral Psychology Studies
- Renal and Vascular Pathologies
- Traumatic Brain Injury and Neurovascular Disturbances
- Abdominal vascular conditions and treatments
- Child and Adolescent Psychosocial and Emotional Development
- Posttraumatic Stress Disorder Research
- Traumatic Brain Injury Research
- Neural dynamics and brain function
- Pediatric Hepatobiliary Diseases and Treatments
- Neurological disorders and treatments
- Stress Responses and Cortisol
- Liver Disease and Transplantation
- Congenital Heart Disease Studies
- Memory and Neural Mechanisms
Hospital for Sick Children
2014-2025
SickKids Foundation
2014-2025
University of Toronto
2013-2025
Institute for Clinical Evaluative Sciences
2022
Systems, Applications & Products in Data Processing (Canada)
2021
Dalhousie University
2013-2017
Mental Health Research Canada
2014-2016
Health Sciences Centre
2016
Sunnybrook Health Science Centre
2016
University College London
2015
Dystonia is a movement disorder defined by involuntary muscle contractions leading to abnormal postures or twisting and repetitive movements. Classically dystonia has been thought of as the basal ganglia, but newer results in idiopathic lesion-induced adults point broader motor network dysfunction spanning cerebellum, premotor cortex, sensorimotor, frontoparietal regions. It unclear whether similar shared between different etiologies pediatric dystonia. Three cohorts patients with were...
<h3>BACKGROUND AND PURPOSE:</h3> There is a critical need for reliable and clinically feasible imaging technique that can enable prognostication selection revascularization surgery in children with Moyamoya disease. Blood oxygen level–dependent MR assessment of cerebrovascular reactivity, using voluntary breath-hold hypercapnic challenge, one such simple technique. However, its repeatability reliability disease are unknown. The current study sought to address this limitation. <h3>MATERIALS...
Renal-vein thrombosis (RVT) is an infrequent event that accounts for a high proportion of early renal allograft losses, since graft failure secondary to acute irreversible rejection now relatively rare. The cause RVT may be related technical problems, clotting disorders, diabetes, or cyclosporin, but often difficult define.This retrospective study was performed examine the influence aspirin on incidence in cadaveric and living-related transplant recipients receiving cyclosporin-based triple...
Haemodialysis (HD) is critically dependent on the availability of adequate access to systemic circulation, ideally via a native arteriovenous fistula (AVF). The Primary failure rate an AVF ranges between 20–54%, due thrombosis or maturation. There remains limited evidence for use anti-platelet agents and uncertainty as choice agent(s) prevention thrombosis. We present study protocol randomised, double-blind, placebo-controlled, clinical trial examining whether agents, aspirin omega-3 fatty...
Emotionally enhanced memory and susceptibility to intrusive memories after trauma have been linked a deletion variant (i.e., form of gene in which certain amino acids are missing) ADRA2B, the encoding subtype B α 2 -adrenergic receptor, influences norepinephrine activity. We examined 207 participants whether variations this responsible for individual differences affective on initial that alter perceptual awareness. attentional blink, an impairment during rapid serial visual presentation,...
Emotionally salient aspects of the world are experienced with greater perceptual vividness than mundane ones; however, such emotionally enhanced (EEV) may be to different degrees for people. We examined whether BOLD activity associated a deletion variant ADRA2b gene coding α2b adrenoceptor modulates EEV in humans. Relative noncarriers, carriers showed higher levels vividness, ventromedial prefrontal cortex (VMPFC) showing modulation by EEV. Deletion were also more sensitive featural salience...
Introduction: The burden of disease from pediatric arterial ischemic stroke (AIS) includes non-visible disability in the form mental health conditions such as depression and anxiety which impact quality life children families affected by stroke. Objectives: To determine scale phenomenon AIS population a large single-center study, to educate clinicians about this significant risk survivors. Methods: A retrospective analysis prospective cohort school-aged diagnosed with AIS, enrolled between...
Objective We sought to determine the clinical features of hemiplegic cerebral palsy associated with perinatal arterial ischemic stroke or periventricular venous infarction. Methods studied children enrolled at 9 rehabilitation centers across Ontario. compared underlying infarction on clinically acquired brain imaging. Analysis also included prenatal (maternal, prenatal/gestational) and (obstetrical, neonatal) collected from birth records standardized parent interviews. Results The 144 (62%...
Periventricular venous infarction (PVI) is a subtype of perinatal stroke localized to subcortical white matter occurring before 34 weeks gestation. An emerging body literature has reported life-long motor impairments and compromised quality life in patients with PVI. However, there remains paucity foundational knowledge regarding the underlying neurobiological mechanisms that underpin these outcomes. Recent studies (Ferradal et al. Cereb Cortex 29:1218-1229, 2019) brain imaging suggest...
<h3>Background</h3> Awareness to neurocognitive issues after mild traumatic brain injury (mTBI) is increasing, but currently no imaging markers are available for mTBI. Advanced structural recently showed microstructural tissue changes and axonal injury, likely sufficient lead functional deficits. Magnetoencephalography (MEG) has high temporal spatial resolution, combining electrophysiological information, can be used examine activation patterns of regions involved with specific tasks....
Abstract Emotion regulation mediates socio‐cognitive functions and is essential for interactions with others. The capacity to automatically inhibit responses emotional stimuli an important aspect of emotion regulation; the underlying neural mechanisms this ability have been rarely investigated. Forty adults completed a Go/No‐go task during magnetoencephalographic (MEG) recordings, where they responded rapidly either blue or purple frame which contained angry happy faces. Subjects target...
<h3>BACKGROUND AND PURPOSE:</h3> Moyamoya is a progressive steno-occlusive arteriopathy. MR imaging assessment of cerebrovascular reactivity can be performed by measuring the blood oxygen level–dependent response to vasoactive stimuli. Our objective was determine whether negative status predictive ischemic events in childhood moyamoya. <h3>MATERIALS METHODS:</h3> We conducted retrospective study consecutive cohort children with moyamoya who underwent reactivity. The charts patients written...
It is well known that we continuously filter incoming sensory information, selectively allocating attention to what important while suppressing distracting or irrelevant information. Yet questions remain about spatiotemporal patterns of neural processes underlying attentional biases toward emotionally significant aspects the world. One index affectively biased an emotional variant blink (AB) paradigm, which reveals enhanced perceptual encoding for salient over neutral stimuli under...
Posttraumatic stress disorder (PTSD) is a mental that stems from exposure to one or more traumatic events. While PTSD thought result dysregulation of emotional neurocircuitry, neurocognitive difficulties are frequently reported. Mental flexibility core executive function involves the ability shift and adapt new information. It essential for appropriate social-cognitive behaviours. Magnetoencephalography (MEG), neuroimaging modality with high spatial temporal resolution, has been used track...
Neurocognitive deficits are common among survivors of aneurysmal subarachnoid hemorrhage, even those with good outcomes and no structural lesions. This study aims to probe the neurophysiological underpinnings cognitive dysfunction patients ruptured intracranial aneurysms using magnetoencephalography (MEG).Thirteen who had undergone uncomplicated coiling for hemorrhage 13 matched controls were enrolled. Neuropsychological tests done before scans. Magnetoencephalography data acquired in a...
<h3>BACKGROUND AND PURPOSE:</h3> Task-based fMRI is a noninvasive method of determining language dominance; however, not all children can complete tasks due to age, cognitive/intellectual, or barriers. Task-free approaches such as resting-state offer an alternative method. This study evaluated for predicting laterality in with drug-resistant epilepsy. <h3>MATERIALS METHODS:</h3> A retrospective review 43 epilepsy who had undergone and task-based during presurgical evaluation was conducted....
Abstract Objective Dystonia is a movement disorder defined by involuntary muscle contractions leading to abnormal postures or twisting and repetitive movements. Classically dystonia has been thought of as the basal ganglia, but newer results in idiopathic lesion-induced adults point broader motor network dysfunction spanning cerebellum, premotor cortex, sensorimotor, frontoparietal regions. It unclear whether similar shared between different etiologies pediatric dystonia. Methods Three...
To determine the nature and incidence of gallstone-related complications arising in patients awaiting laparoscopic cholecystectomy to formulate a strategy detect those most need urgent intervention.A retrospective analysis case notes 337 consecutive undergoing under single surgeon district general hospital between 1995 1999.Of cholecystectomy, 65 (19.3%) were documented as suffering significant on-going symptoms, whom 19 (5.6%) required admission or surgical review at median 8.9 weeks (range...