A5084593174- Advanced MRI Techniques and Applications
- MRI in cancer diagnosis
- Cardiac Imaging and Diagnostics
- Cerebrovascular and Carotid Artery Diseases
- Advanced Neuroimaging Techniques and Applications
- Lanthanide and Transition Metal Complexes
- Functional Brain Connectivity Studies
- Atomic and Subatomic Physics Research
- Electron Spin Resonance Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Acute Ischemic Stroke Management
- Medical Imaging Techniques and Applications
- Intracranial Aneurysms: Treatment and Complications
- Coronary Interventions and Diagnostics
- Cardiovascular Health and Disease Prevention
- Long-Term Effects of COVID-19
- Pain Mechanisms and Treatments
- Medical Image Segmentation Techniques
- Musculoskeletal pain and rehabilitation
- Visual perception and processing mechanisms
- Optical Imaging and Spectroscopy Techniques
- Health, Environment, Cognitive Aging
- Blind Source Separation Techniques
- Intensive Care Unit Cognitive Disorders
- Cerebrospinal fluid and hydrocephalus
Wellcome Centre for Integrative Neuroimaging
2015-2024
University of Oxford
2015-2024
Vrije Universiteit Amsterdam
2024
John Radcliffe Hospital
2009-2018
Oxford BioMedica (United Kingdom)
2016
Churchill Hospital
2010
BackgroundThe medium-term effects of Coronavirus disease (COVID-19) on organ health, exercise capacity, cognition, quality life and mental health are poorly understood.MethodsFifty-eight COVID-19 patients post-hospital discharge 30 age, sex, body mass index comorbidity-matched controls were enrolled for multiorgan (brain, lungs, heart, liver kidneys) magnetic resonance imaging (MRI), spirometry, six-minute walk test, cardiopulmonary test (CPET), life, cognitive assessments.FindingsAt 2–3...
Abstract Accurate assessment of cerebral perfusion is vital for understanding the hemodynamic processes involved in various neurological disorders and guiding clinical decision‐making. This guidelines article provides a comprehensive overview quantitative imaging brain using multi‐timepoint arterial spin labeling (ASL), along with recommendations its acquisition quantification. A major benefit acquiring ASL data multiple label durations and/or post‐labeling delays (PLDs) being able to...
The original concept of the ischaemic penumbra suggested imaging regional cerebral blood flow and metabolism would be required to identify tissue that may benefit from intervention. Amide proton transfer magnetic resonance imaging, a chemical exchange saturation technique, has been used derive intracellular pH in preclinical stroke models proposed as metabolic marker penumbra. In this proof principle clinical study, we explored potential pH-weighted technique at tissue-level. Detailed...
Until recently, no direct comparison between [ 15 O]water positron emission tomography (PET) and arterial spin labeling (ASL) for measuring cerebral blood flow (CBF) was possible. With the introduction of integrated, hybrid magnetic resonance (MR)-PET scanners, such a becomes feasible. This study presents results CBF measurements recorded simultaneously with ASL. A 3T MR-BrainPET scanner used simultaneous acquisition pseudo-continuous ASL (pCASL) imaging (MRI) PET. Quantitative values were...
<h3>Importance</h3> Risk of stroke and brain atrophy in later life relate to levels cardiovascular risk early adulthood. However, it is unknown whether cerebrovascular changes are present young adults. <h3>Objective</h3> To examine relationships between modifiable factors structure, function, white matter integrity <h3>Design, Setting, Participants</h3> A cross-sectional observational study 125 adults (aged 18-40 years) without clinical evidence disease. Data collection was completed August...
Abstract Background The medium-term effects of Coronavirus disease (COVID-19) on multiple organ health, exercise capacity, cognition, quality life and mental health are poorly understood. Methods Fifty-eight COVID-19 patients post-hospital discharge 30 comorbidity-matched controls were prospectively enrolled for multiorgan (brain, lungs, heart, liver kidneys) magnetic resonance imaging (MRI), spirometry, six-minute walk test, cardiopulmonary test (CPET), life, cognitive assessments. Findings...
Amide proton transfer (APT) imaging is a pH mapping method based on the chemical exchange saturation phenomenon that has potential for penumbra identification following stroke. The majority of literature thus far focused generating pH-weighted contrast using magnetization ratio asymmetry analysis instead quantitative mapping. In this study, widely used and model-based were both assessed APT data collected from healthy subjects (n = 2) hyperacute stroke patients 6, median time after onset 2...
Arterial spin labeling (ASL) techniques are gaining popularity for visualizing and quantifying cerebral blood flow (CBF) in a range of patient groups. However, most ASL methods lack vessel-selective information, which is important the assessment collateral arterial supply to lesions. In this study, we explored use vessel-encoded pseudocontinuous (VEPCASL) with multiple postlabeling delays obtain individual quantitative CBF bolus arrival time maps each four main brain-feeding arteries...
Abstract An increased understanding of the relationship between structural connections and functional behavioral outcomes is an essential but under-explored topic in neuroscience. During transcranial direct current stimulation (tDCS)–induced analgesia, neuromodulation occurs through a top-down process that depends on inter-regional connections. To investigate whether variation anatomical connectivity explains behavorial during neuromodulation, we first combined tDCS tonic pain model with...
Arterial spin labeling (ASL) is a non-invasive MRI technique that allows for quantitative measurement of cerebral perfusion. Incomplete or inaccurate reporting acquisition parameters complicates quantification, analysis, and sharing ASL data, particularly studies across multiple sites, platforms, methods. There strong need standardization data storage, including metadata. Recently, ASL-BIDS, the BIDS extension ASL, was developed released in 1.5.0. This manuscript provides an overview...
When the primary visual cortex (V1) is damaged, there are a number of alternative pathways that can carry information from eyes to extrastriate areas. Damage trauma or infarct often unilateral, extensive and includes gray matter white tracts, which disrupt other routes residual function. We report an unusual young patient, SBR, who has bilateral damage V1, sparing adjacent surrounding Using functional magnetic resonance imaging (fMRI), we show area MT+/V5 activated bilaterally stimulation,...
Purpose Arterial spin labeling (ASL) MRI is a non‐invasive perfusion imaging technique that inherently SNR limited, so scan protocols ideally need to be rigorously optimized provide the most accurate measurements. A general framework presented for optimizing ASL experiments achieve optimal accuracy estimates and, if required, other hemodynamic parameters, within fixed time. The effectiveness of this then demonstrated by post‐labeling delays (PLDs) multi‐PLD pseudo‐continuous experiment and...
Collateral blood flow plays a pivotal role in steno-occlusive internal carotid artery (ICA) disease to prevent irreversible ischaemic damage. Our aim was investigate the effect of upon cerebral perfusion and cerebrovascular reactivity whether haemodynamic impairment is influenced at brain tissue level by existence primary and/or secondary collateral. Eighty-eight patients with ICA 29 healthy controls underwent MR examination. The presence collaterals determined time-of-flight,...
Amide proton transfer (APT) imaging may help identify the ischaemic penumbra in stroke patients, classical definition of which is a region tissue around core that hypoperfused and metabolically stressed. Given potential APT to complement existing techniques provide clinically-relevant information, there need develop analysis deliver robust repeatable metric. The challenge accurate quantification an metric has been heterogeneous in-vivo environment human tissue, exhibits several confounding...
Purpose To assess the impact of different post‐processing options in calibration arterial spin labeling (ASL) data on perfusion quantification and its reproducibility. Theory Methods Absolute measurements is one promises ASL techniques. However, it highly dependent a procedure that involves complex processing pipeline for which no standardized has been fully established. In this work, we systematically compare main methods as well various options, using 2 sets acquired with most common...
Poor cardiovascular health is an established risk factor for dementia, but little known about its association with brain physiology in older adults.To examine the of factors, measured repeatedly during a 20-year period, cerebral perfusion at ages.In this longitudinal cohort study, individuals were selected from Whitehall II Imaging Substudy. Participants included if they had no clinical diagnosis gross structural abnormalities on magnetic resonance imaging scans, and received...
Abstract Arterial Spin Labelling (ASL) MRI is now an established non-invasive method to quantify cerebral blood flow and increasingly being used in a variety of neuroimaging applications. With standard ASL acquisition protocols widely available, there growing interest advanced options that offer added quantitative precision information about haemodynamics beyond perfusion. In this article, we introduce the BASIL toolbox, research tool for analysis data included within FMRIB Software Library...
Arterial spin labeling (ASL) sequences that incorporate multiple postlabeling delay (PLD) times allow estimation of when arterial blood signal arrives within a region interest. Sequences account for such variability may improve the reliability ASL and therefore make technique well suited future clinical experimental investigations cerebral perfusion. This study assessed within- between-session reproducibility an optimized pseudo-continuous (pCASL) functional magnetic resonance imaging (FMRI)...