A5022564294- Visual perception and processing mechanisms
- Neural dynamics and brain function
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Ophthalmology and Visual Impairment Studies
- Retinal Development and Disorders
- Advanced MRI Techniques and Applications
- Glaucoma and retinal disorders
- Neuroscience and Neuropharmacology Research
- Tactile and Sensory Interactions
- Vestibular and auditory disorders
- Retinal Diseases and Treatments
- Ocular Disorders and Treatments
- Face Recognition and Perception
- Neural and Behavioral Psychology Studies
- Neurobiology and Insect Physiology Research
- Retinal Imaging and Analysis
- Transcranial Magnetic Stimulation Studies
- Retinal and Optic Conditions
- Spatial Neglect and Hemispheric Dysfunction
- Migraine and Headache Studies
- Optical Imaging and Spectroscopy Techniques
- Olfactory and Sensory Function Studies
- Glycogen Storage Diseases and Myoclonus
- Color perception and design
University of Oxford
2016-2025
Wellcome Centre for Integrative Neuroimaging
2016-2025
John Radcliffe Hospital
2012-2024
Anglo-Norman Text Society
2024
University of Turin
2023
Wellcome Centre for Human Neuroimaging
2022
HollyFrontier (United States)
2021
Nuffield Orthopaedic Centre
2017-2018
Google (United States)
2016
Science Oxford
2011-2014
Neuroscience is advancing standardization and tool development to support rigor transparency. Consequently, data pipeline complexity has increased, hindering FAIR (findable, accessible, interoperable reusable) access. brainlife.io was developed democratize neuroimaging research. The platform provides standardization, management, visualization processing automatically tracks the provenance history of thousands objects. Here, described evaluated for validity, reliability, reproducibility,...
The full extent of the brain's ability to compensate for damage or changed experience is yet be established. One question particularly important evaluating and understanding rehabilitation following brain whether recovery involves new aberrant neural connections any change in function due functional recruitment existing pathways, both. Blindsight, a condition which subjects with complete destruction part striate cortex (V1) retain extensive visual capacities within clinically blind field, an...
Stereoscopic vision relies mainly on relative depth differences between objects rather than their absolute distance in from where the eyes fixate. However, disparities are computed disparities, and it is not known these two stages represented human brain. Using functional MRI (fMRI), we assessed disparity selectivity with stereoscopic stimuli consisting of pairs transparent planes which signals could be independently manipulated (at a local spatial scale). In experiment 1, was kept constant,...
Although damage to the primary visual cortex (V1) causes hemianopia, many patients retain some residual vision; known as blindsight. We show that blindsight may be facilitated by an intact white-matter pathway between lateral geniculate nucleus and motion area hMT+. Visual psychophysics, diffusion-weighted magnetic resonance imaging fibre tractography were applied in 17 with V1 acquired during adulthood 9 age-matched controls. Individuals subdivided into positive (preserved vision) negative...
Combined fMRI-MRS is a novel method to non-invasively investigate functional activation in the human brain using simultaneous acquisition of hemodynamic and neurochemical measures. The aim current study was quantify neural activity combined at 7 T. BOLD-fMRI semi-LASER localization MRS data were acquired from visual cortex 13 participants during short blocks (64 s) flickering checkerboards. We demonstrate correlation between glutamate time courses (R=0.381, p=0.031). In addition, we show...
The expertise of others is a major social influence on our everyday decisions and actions. Many viewers art, whether expert or naïve, are convinced that the full esthetic appreciation an artwork depends upon assurance work genuine rather than fake. Rembrandt portraits provide interesting image set for testing this idea, as there large number them recent scholarship has determined quite few fakes copies exist. Use allowed us to separate brain's response images fake pictures from external...
The functional specialization of the human brain means that many regions are dedicated to processing a single sensory modality. When modality is absent, as in congenital total blindness, 'visual' can be reliably activated by non-visual stimuli. connections underlying this adaptation, however, remain elusive. In study, using structural and diffusion-weighted magnetic resonance imaging, we investigated differences brains six bilaterally anophthalmic subjects compared with sighted subjects....
The cerebral cortex has both anatomical and functional specialization, but the level of correspondence between two in human brain remained largely elusive. Recent successes high-resolution magnetic resonance imaging myeloarchitecture patterns suggest that it may now be possible to compare directly anatomy function vivo. We independently investigated borders primary secondary visual areas (V1 V2) Functional were mapped with (fMRI) using a narrow, vertical black white contrast-reversing wedge....
The role of the primary visual cortex in mental imagery has provided significant debate literature. Functional neuroimaging studies show considerable variation depending on task and technique. Patient can be difficult to interpret due diverse nature cortical damage. type damage patient SBR is exceedingly rare as it restricted gray matter calcarine sulcus. In this study, we that spite his near-complete blindness, exhibits vivid both behaviorally when measured with functional magnetic...
Imaging studies in blind subjects have consistently shown that sensory and cognitive tasks evoke activity the occipital cortex, which is normally visual. The precise areas involved degree of activation are dependent upon cause age onset blindness. Here, we investigated cortical language network at rest during an auditory covert naming task five bilaterally anophthalmic subjects, who never received visual input. When listening to definitions covertly retrieving words, these activated lateral...
Motion area V5/MT+ shows a variety of characteristic visual responses, often linked to perception, which are heavily influenced by its rich connectivity with the primary cortex (V1). This human motion also receives number inputs from other regions, including direct subcortical connections and callosal contralateral hemisphere. Little is currently known about such alternative how they may drive influence activity. Using functional magnetic resonance imaging, response increasing proportion...
To investigate whether there is transsynaptic degeneration in the human optic tract hemianopia. consider how varies with duration of hemianopia and location insult.Seven patients damage to primary visual cortex (V1), lateral geniculate nucleus (LGN), or were scanned structural MRI. The volume cross-sectional area left right tracts computed based on intensity values T1-weighted image. High correspond voxels high white matter content, decrease as content drops (indicating degeneration). A...
Background Visual aura is present in about one-third of migraine patients and triggering by bright or flickering lights frequently reported. Method Using with visual patients, we investigated the neurochemical profile cortex using magnetic resonance spectroscopy. Specifically, glutamate/creatine GABA/creatine ratios were quantified occipital female patients. Results GABA levels lower than that controls. Glutamate but not controls, correlated blood-oxygenation-level-dependent (BOLD) signal...
Previous imaging studies of congenital blindness have studied individuals with heterogeneous causes blindness, which may influence the nature and extent cross-modal plasticity. Here, we scanned a homogeneous group blind people bilateral anophthalmia, condition in both eyes fail to develop, and, as result, visual pathway is not stimulated by either light or retinal waves. This model presents an opportunity investigate effects very early deafferentation on functional organization brain. In...
When the primary visual cortex (V1) is damaged, there are a number of alternative pathways that can carry information from eyes to extrastriate areas. Damage trauma or infarct often unilateral, extensive and includes gray matter white tracts, which disrupt other routes residual function. We report an unusual young patient, SBR, who has bilateral damage V1, sparing adjacent surrounding Using functional magnetic resonance imaging (fMRI), we show area MT+/V5 activated bilaterally stimulation,...
Loss of shape recognition in visual-form agnosia occurs without equivalent losses the use vision to guide actions, providing support for hypothesis two visual systems (for “perception” and “action”). The human individual DF received a toxic exposure carbon monoxide some years ago, which resulted persisting that has been extensively characterized at behavioral level. We conducted detailed high-resolution MRI study DF9s cortex, combining structural functional measurements. present first...
Early visual areas have neuronal receptive fields that form a sampling mosaic of space, resulting in series retinotopic maps which the same region space is represented multiple areas. It not clear to what extent development and maintenance this organization humans depend on retinal waves and/or experience. We examined corticocortical field resting-state BOLD data normally sighted, early blind, anophthalmic (in both eyes fail develop) individuals found correlations between V1 V2/V3 were...
When the primary visual cortex (V1) is damaged, principal pathway lost, causing a loss of vision in opposite field. While conscious impaired, patients can still respond to certain images; this known as 'blindsight'. Recently, direct anatomical connection between lateral geniculate nucleus (LGN) and human motion area hMT+ has been implicated blindsight. However, functional these structures not demonstrated. We quantified MRI responses 14 with unilateral V1 damage (with without blindsight)....
We investigated the relationship between neurochemical and hemodynamic responses as a function of image contrast in human primary visual cortex (V1). Simultaneously acquired BOLD-fMRI single voxel proton MR spectroscopy signals were measured V1 24 healthy participants either sex at 7 tesla field strength, response to presentations (64 s blocks) different levels (3%, 12.5%, 50%, 100%). Our results suggest that complementary measures neurotransmission energy metabolism are partial agreement:...