A5080369451- Neurofibromatosis and Schwannoma Cases
- Meningioma and schwannoma management
- Bone Tumor Diagnosis and Treatments
- Parallel Computing and Optimization Techniques
- Distributed and Parallel Computing Systems
- Medical Image Segmentation Techniques
- Cerebrovascular and Carotid Artery Diseases
- Glioma Diagnosis and Treatment
- Brain Tumor Detection and Classification
- Advanced MRI Techniques and Applications
- Advanced Neural Network Applications
- Radiomics and Machine Learning in Medical Imaging
- Intracranial Aneurysms: Treatment and Complications
- MRI in cancer diagnosis
- Advanced Data Storage Technologies
- Vascular Malformations Diagnosis and Treatment
- Visual perception and processing mechanisms
- Functional Brain Connectivity Studies
- Patient-Provider Communication in Healthcare
- Simulation Techniques and Applications
- Chromatin Remodeling and Cancer
- Cardiovascular Health and Disease Prevention
- Color Science and Applications
- Lanthanide and Transition Metal Complexes
- Spinal Dysraphism and Malformations
Akershus University Hospital
2021-2024
Salford Royal NHS Foundation Trust
2015-2024
Manchester Academic Health Science Centre
2017-2024
Salford Royal Hospital
2020-2024
Countess of Chester Hospital NHS Foundation Trust
2017
University of Cambridge
2012-2015
Cambridge University Hospitals NHS Foundation Trust
2012-2014
Addenbrooke's Hospital
2013
Data61
2010
John Radcliffe Hospital
2008
The full extent of the brain's ability to compensate for damage or changed experience is yet be established. One question particularly important evaluating and understanding rehabilitation following brain whether recovery involves new aberrant neural connections any change in function due functional recruitment existing pathways, both. Blindsight, a condition which subjects with complete destruction part striate cortex (V1) retain extensive visual capacities within clinically blind field, an...
Objectives Schwannomatosis is a dominantly inherited condition predisposing to schwannomas of mainly spinal and peripheral nerves with some diagnostic overlap neurofibromatosis-2 (NF2), but the underlying epidemiology poorly understood. We present birth incidence prevalence allowing for NF2. Methods NF2 cases were ascertained from Manchester region England (population=4.8 million) across UK. Point calculated regional statistics. Genetic analysis was also performed on , LZTR1 SMARCB1 blood...
To evaluate the incidence of mosaicism in de novo neurofibromatosis 2 (NF2).Patients fulfilling NF2 criteria, but with no known affected family member from a previous generation (n = 1055), were tested for variants lymphocyte DNA and where available tumor DNA. The proportion individuals proven or presumed mosaic variant was assessed allele frequencies identified evaluated using next-generation sequencing.The rate proven/presumed 232/1055 (22.0%). However, nonmosaic heterozygous pathogenic...
Neurofibromatosis 1 (NF1) is a monogenic model for syndromic autism. Statins rescue the social and cognitive phenotype in animal knockout models, but translational trials with subjects > 8 years using cognition/behaviour outcomes have shown mixed results. This trial breaks new ground by studying statin effects first time younger children NF1 co-morbid autism multiparametric imaging outcomes. A single-site triple-blind RCT of simvastatin vs. placebo was done. Assessment (baseline 12-week...
Abstract Background Radiation treatment of benign tumors in tumor predisposition syndromes is controversial, but short-term studies from centers suggest safety despite apparent radiation-associated malignancy being reported. We determined whether radiation NF2-related schwannomatosis patients associated with increased rates subsequent (M)/malignant progression (MP). Methods All UK NF2 were eligible if they had a clinical/molecular diagnosis. Cases treated for tumors. Controls matched...
Objectives New diagnostic criteria for NF2-related schwannomatosis (NF2) were published in 2022. An updated UK prevalence was generated accordance with these, an emphasis on the rate of de novo NF2 (a 50% frequency is widely quoted genetic counselling). The distribution variant types among and familial cases also assessed. Methods National database identifies patients meeting from a highly ascertained population cared by England’s specialised service. Diagnostic assessed 1 February 2023....
The relationship of proliferation to the developmental sequence associated with bone cell differentiation was examined in primary osteoblast cultures derived from fetal rat and embryonic chick calvaria. A reciprocal functional exists between decline proliferative activity which occurs during initial stages induction genes encoding phenotype proteins matrix maturation mineralization. This is supported by 1) a temporal events there an enhanced expression alkaline phosphatase (AP) osteopontin...
Loss of shape recognition in visual-form agnosia occurs without equivalent losses the use vision to guide actions, providing support for hypothesis two visual systems (for “perception” and “action”). The human individual DF received a toxic exposure carbon monoxide some years ago, which resulted persisting that has been extensively characterized at behavioral level. We conducted detailed high-resolution MRI study DF9s cortex, combining structural functional measurements. present first...
<h3>BACKGROUND AND PURPOSE:</h3> Dilated perivascular spaces have been shown to be a specific biomarker of cerebral small-vessel disease in young patients with dementia. Our aim was examine the discriminative power dilated as biomarkers very elderly population <h3>MATERIALS METHODS:</h3> We studied healthy volunteers (<i>n</i> = 65; mean age, 78 ± 5.6 years) and subjects vascular dementia 39; 76.9 7.7 Alzheimer 47; 74.1 8.5 years). compared white matter hyperintensity 2 semiquantitative...
Abstract Background Limited data exist on the disease course of neurofibromatosis type 2 (NF2) to guide clinical trial design. Methods A prospective database patients meeting NF2 diagnostic criteria, reviewed between 1990 and 2020, was evaluated. Follow-up first vestibular schwannoma (VS) intervention death assessed by univariate analysis stratified age at onset, era referred, inheritance type. Interventions for NF2-related tumors were assessed. Cox regression performed determine...
The impact of calcification on the carotid atherosclerotic plaque vulnerability remains controversial and unclear. This study assesses critical mechanical conditions induced by calcium at lumen surface, i.e., juxtaluminal (JLCa), within human plaque. Eleven patients with evidence JLCa were included for analysis. geometry was reconstructed based computed tomography magnetic resonance images 3-D fluid-structure interaction simulation used presence increased local stresses compared to when...
The published literature suggests that malignant peripheral nerve sheath tumors (MPNST) occur at increased frequency in neurofibromatosis type 2 (NF2). A recent review based on incidence data North America showed 1 per 1000 cerebellopontine angle were malignant.To determine whether MPNST occurred spontaneously NF2 by reviewing our database.The prospective database consists of 1253 patients with NF2. One thousand and nine are known to be alive last follow-up. presence laterality/pathology...
Objectives/Hypothesis Unilateral vestibular schwannoma (VS) occurs with a lifetime risk of around 1 in 1,000 and is due to inactivation the NF2 gene, either somatically or from constitutional mutation. It has been postulated that familial occurrence unilateral VS more frequently than by chance, but no causal mechanism confirmed. Study Design Retrospective database analysis. Methods The likelihood chance VS, occurring context neurofibromatosis type 2 (NF2), was assessed using national UK...
Background Hospitals should adopt multiple methods to monitor incidents for a comprehensive review of the types that occur. Contrary traditional incident reporting systems, Green Cross (GC) method is simple visual recognise based on teamwork and safety briefings. Its longitudinal effect patient culture has not been previously assessed. This study aimed explore whether implementation GC in postanaesthesia care unit changed nurses’ perceptions different factors associated with over 4 years....
The Manchester criteria for neurofibromatosis type 2 (NF2) include a range of tumors, and gliomas were incorporated in the original description. are now widely accepted to be predominantly spinal cord ependymomas.To determine whether these any cases malignant glioma (WHO grade III IV) through database review.The prospective consists 1253 patients with NF2. 1009 known alive at last follow-up.There was single case glioblastoma multiforme (GBM; World Health Organization series no WHO gliomas....
Objective To evaluate the effect of a specific communication training for neurologists on how to provide complex information about treatment options patients with multiple sclerosis (MS). Design Single-centre, single-blind, randomised controlled trial. Setting One university hospital in Norway. Participants Thirty-four early-stage MS. Intervention A 3-hour MS escalation therapy. Main outcome measures Patient recall rate, measured reliable counting system provided and recalled drugs....