A5102901828- Cancer Genomics and Diagnostics
- Pancreatic and Hepatic Oncology Research
- Sulfur-Based Synthesis Techniques
- Surface and Thin Film Phenomena
- Single-cell and spatial transcriptomics
- Immune Cell Function and Interaction
- Cancer Cells and Metastasis
- RNA Interference and Gene Delivery
- Semiconductor materials and interfaces
- Plant Virus Research Studies
- Synthesis and Catalytic Reactions
- Transgenic Plants and Applications
- Asthma and respiratory diseases
- Semiconductor materials and devices
- Plant Disease Resistance and Genetics
- Plant tissue culture and regeneration
- Context-Aware Activity Recognition Systems
- T-cell and B-cell Immunology
- Mast cells and histamine
- Phytase and its Applications
- Cell Adhesion Molecules Research
- Chemical Reaction Mechanisms
- Antimicrobial Peptides and Activities
- Organic Chemistry Cycloaddition Reactions
- Cholangiocarcinoma and Gallbladder Cancer Studies
Korea Advanced Institute of Science and Technology
1993-2025
Dongguk University Ilsan Hospital
2024
Yeungnam University
2024
Sogang University
2005-2023
Kootenay Association for Science & Technology
2022
Catholic University of Korea
2021
Hewlett-Packard (United States)
2005
We have generated 47,932 T-DNA tag lines in japonica rice using activation-tagging vectors that contain tetramerized 35S enhancer sequences. To facilitate use of those lines, we isolated the genomic sequences flanking inserted via inverse polymerase chain reaction. For most performed four sets amplifications two different restriction enzymes toward both directions. In analyzing 41,234 obtained 27,621 sequence tags (FSTs), among which 12,505 were integrated into genic regions and 15,116...
Abstract Background Recent studies using single-cell transcriptomic analysis have reported several distinct clusters of neoplastic epithelial cells and cancer-associated fibroblasts in the pancreatic cancer tumor microenvironment. However, their molecular characteristics biological significance not been clearly elucidated due to intra- inter-tumoral heterogeneity. Methods We performed RNA sequencing enriched non-immune cell populations from 17 tissues (16 one high-grade dysplasia) generated...
The complexity of the tumor microenvironment poses significant challenges in cancer therapy. Here, to comprehensively investigate tumor-normal ecosystems, we perform an integrative analysis 4.9 million single-cell transcriptomes from 1070 and 493 normal samples combination with pan-cancer 137 spatial transcriptomics, 8887 TCGA, 1261 checkpoint inhibitor-treated bulk tumors. We define a myriad cell states constituting ecosystems also identify hallmark gene signatures across different types...
mRNA vaccines against SARS-CoV-2 have revolutionized vaccine development, but their immunological mechanisms are not fully understood. Here, we investigate injection site responses of by generating a comprehensive single-cell transcriptome profile upon lipid nanoparticle (LNP) or LNP-mRNA challenge in female BALB/c mice. We show that LNP-induced stromal pro-inflammatory and mRNA-elicited type I interferon dominate the initial responses. By tracking fate delivered mRNA, discover fibroblasts...
Abstract Background Management of early‐stage gallbladder cancer is becoming more important as the rate early detection increasing. Although there have been many studies about clinical implication invasion depth or peritoneal/hepatic location cancers, no study on geometric along longitudinal length gallbladder. Methods The was defined center primary site a tumour, which lies diameter surgical specimens. We compared oncologic outcomes following surgery between cancers located fundal end and...
Abstract Eosinophils are major effector cells in type 2 immune responses, contributing to host defense and allergic diseases. They also play critical roles maintaining tissue homeostasis by regulating various cell types. However, evidence of the crosstalk between eosinophils neutrophils is limited. Here, we show that directly associate with lungs asthma-induced mice. Eosinophil-specific deficiency short-chain fatty acid receptor GPR43 results hyperactivation increases expression neutrophil...
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Abstract Tetraspanin family proteins form a rigid membrane structure called tetraspanin-enriched microdomain (TEM) on the plasma and regulate multiple cellular processes. CD82, tetraspanin protein, is highly expressed in various immune cells, but its role responses has been poorly understood. In this study, we investigated of CD82 T cells using knock-out (KO) mice. At steady state, KO mice had less memory CD8+ secondary lymphoid organs compared to wild type mice, which became more pronounced...
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Abstract Background: Despite the advances in diagnosis and treatment of cancer patients over past decades, 5-year survival rate pancreatic (PC) still remains lower than 10%. This is because more 80% PC are diagnosed with unresectable or metastatic disease, receive systemic chemotherapy as a first-line therapy, but currently preferred regimens do not extend patients’ by 12 months. To improve clinical outcomes, comprehensive understanding molecular biology cells, along extensive stromal cells...
Abstract β1,3-galactose is the component of outer-chain elongation complex N-glycans that, together with α1,4-fucose, forms Lewis a structures in plants. Previous studies have revealed that N-glycan maturation mediated by sequential attachment and α1,4-fucose individual β1,3-galactosyltransferase (GalT) α1,4-fucosyltransferase (1,4-FucT), respectively. Although GalT from several species has been studied, little information about rice available. I therefore characterized three candidate genes...