A5100393331- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Neuroinflammation and Neurodegeneration Mechanisms
- SARS-CoV-2 and COVID-19 Research
- CAR-T cell therapy research
- Immune Response and Inflammation
- Cancer Immunotherapy and Biomarkers
- Viral-associated cancers and disorders
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- COVID-19 Clinical Research Studies
- Ocular Diseases and Behçet’s Syndrome
- Barrier Structure and Function Studies
- Cerebral Venous Sinus Thrombosis
- Signaling Pathways in Disease
- Galectins and Cancer Biology
- Cell Adhesion Molecules Research
- Ocular and Laser Science Research
- Vector-Borne Animal Diseases
- Herpesvirus Infections and Treatments
- Nasal Surgery and Airway Studies
- Inhalation and Respiratory Drug Delivery
- Bartonella species infections research
- Viral Infections and Outbreaks Research
- Occupational exposure and asthma
Korea Advanced Institute of Science and Technology
2021-2025
Institute for Basic Science
2023-2024
CHA Bundang Medical Center
2022
CHA University
2022
Scope Group (United States)
2022
Chonnam National University Hospital
2017
Armed Forces Capital Hospital
2006
Digestive Health Research Institute
2003
Digestive Disease Research Institute
2003
Here, we examine peripheral blood memory T cell responses against the SARS-CoV-2 BA.4/BA.5 variant spike among vaccinated individuals with or without Omicron breakthrough infections. We provide evidence supporting a lack of original antigenic sin in CD8 + targeting spike. show that BNT162b2-induced cells respond to Among BA.1/BA.2 infections, IFN-γ–producing increased. In subgroup BA.2 BA.2-mutated region increased and correlated directly spike, indicating spike–specific elicited by...
High neonatal susceptibility to meningitis has been attributed the anatomical barriers that act protect central nervous system (CNS) from infection being immature and not fully developed. However, mechanisms by which pathogens breach CNS are poorly understood. Using Armstrong strain of lymphocytic choriomeningitis virus (LCMV) study propagation into during systemic infection, we demonstrate mortality in neonatal, but adult, mice is high after infection. Virus propagated extensively...
Summary Here we investigated the regulatory mechanisms of TCR-independent bystander activation and NK-like cytotoxicity human memory CD8 + T cells. We found that TCR signals suppressed characteristic features IL-15-induced T-cell activation, including increased NKG2D expression upregulation genes related to NK IFN response. Moreover, ionomycin cytotoxicity, indicating Ca 2+ -calcineurin signaling is responsible for TCR-mediated suppression activation. In detail, NFATc1 IL-15- induced via...
Abstract. Several methods have been developed for the immortalization of B lymphocytes by Epstein‐Barr virus (EBV). We an efficient method which reduces time from culture initiation to and cryopreservation. Two infections EBV lymphocytes, use phorbol ester‐induced stock significantly improved efficiency reduced between The resulting cell bank was used produce DNA genetic studies focusing on genes involved in immune autistic disorders.
Introduction: The classically defined two retinal microglia layers are distributed in inner and outer plexiform layers. Although there some reports that also superficially located around the ganglion cell layer (GCL) contact with vitreous, has been a lack of detailed descriptions not fully understood yet. Methods: We visualized microglial by using CX3CR1-GFP (C57BL6) transgenic mice both healthy disease conditions including NaIO3-induced degeneration models IRBP-induced auto-immune uveitis...
Background: Herpes zoster (HZ) is caused by reactivation of latent varicella-zoster virus (VZV) infection.HZ-associated aseptic meningitis, a rare complication HZ, can require hospitalization and long treatment period.Objective: A retrospective study was performed to identify potential factors associated with HZ-associated meningitis development.Methods: We included all outpatients patients admitted in the neurology dermatology departments single tertiary center, who were diagnosed HZ for...
We conducted an epidemiologic study to understand temporal and spatial patterns of hemorrhagic fever with renal syndrome (HFRS) in the Republic Korea (ROK). estimated incidence among civilians endemic areas through active surveillance system during major epidemic periods, from September December, between 1996 1998. also prevalence Korean military personnel 1995 In addition, we assessed seroprevalence, subclinical infection rate, vaccination rates both personnel. The ranged 2.1 6.6 per 100,...
Animal models of retinal artery occlusion (RAO) have been widely used in many studies. However, most these studies prefer using a central (CRAO) which is typical global ischemia model the retina, due to technical limitation producing single vessel targeted modeling with real-time imaging. A focal model, such as branch (BRAO), also needed for explaining interactions, including immunological reaction between ischemic retina and adjacent healthy retina. Accordingly, relevant clinical RAO...
Vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been acknowledged as an effective mean of preventing infection and hospitalization. However, the emergence highly transmissible SARS-CoV-2 variants concern (VOCs) led to substantial increase in infections among children adolescents. Vaccine-induced immunity longevity have not well defined this population. Therefore, we aimed analyze humoral cellular immune responses ancestral after two shots BNT162b2 vaccine...
Numerous attempts have been made to devise treatments for ischemic foot ulcer (IFU), which is one of the most severe and fatal consequences diabetes mellitus (DM). Pericytes, are perivascular multipotent cells, interest as a treatment option IFU because they play critical role in forming repairing various tissues. In this study, we want clarify angiogenic potential pericytes DM-induced wounds.We evaluated pericyte stimulation capability tube formation, angiogenesis, wound healing (cell...
Abstract Tetraspanin family proteins form a rigid membrane structure called tetraspanin-enriched microdomain (TEM) on the plasma and regulate multiple cellular processes. CD82, tetraspanin protein, is highly expressed in various immune cells, but its role responses has been poorly understood. In this study, we investigated of CD82 T cells using knock-out (KO) mice. At steady state, KO mice had less memory CD8+ secondary lymphoid organs compared to wild type mice, which became more pronounced...
Abstract In addition to the classically defined two microglia layers in plexiform layers, a newly discovered retinal layer is superficially located around ganglion cell (GCL) contact with vitreous. We visualized microglial by using CX3CR1-GFP transgenic mice both healthy and disease conditions. As progresses, each gets closer capillary plexus, including superficial, intermediate, deep making inter-glial distances more visible. The GCL has subsets; peripheral (pph) on parenchyma BAM (CNS...