A5065079469- Dermatologic Treatments and Research
- Facial Rejuvenation and Surgery Techniques
- Hair Growth and Disorders
- Skin Protection and Aging
- Dermatology and Skin Diseases
- melanin and skin pigmentation
- Botulinum Toxin and Related Neurological Disorders
- Nail Diseases and Treatments
- Autoimmune Bullous Skin Diseases
- Acne and Rosacea Treatments and Effects
- Allergic Rhinitis and Sensitization
- Laser Applications in Dentistry and Medicine
- Immune Cell Function and Interaction
- Urticaria and Related Conditions
- Wound Healing and Treatments
- Immunotherapy and Immune Responses
- Drug-Induced Adverse Reactions
- Body Contouring and Surgery
- Advancements in Transdermal Drug Delivery
- Food Allergy and Anaphylaxis Research
- Reconstructive Facial Surgery Techniques
- Genetic and rare skin diseases.
- Sympathectomy and Hyperhidrosis Treatments
- Cancer and Skin Lesions
- Skin and Cellular Biology Research
Chung-Ang University
2015-2025
Chung-Ang University Hospital
2015-2025
Korea Advanced Institute of Science and Technology
2019-2023
Michigan United
2020
Studies have reported promising results of mesenchymal stem cell therapies for skin aging. However, in the use cells, some drawbacks including rarely possible tumorigenicity and low engraftment rates limited their widespread clinical use. Adipose tissue cell-derived exosomes (ASCEs) are emerging as effective cell-free therapeutic agents.It was evaluated efficacy combining application human ASCE-containing solution (HACS) with microneedling to treat facial aging.A 12-week, prospective,...
Although the incidence of severe fever with thrombocytopenia syndrome virus (SFTSV) infection has increased from its discovery a mortality rate 10-20%, no effective vaccines are currently available. Here we describe development SFTSV DNA vaccine, immunogenicity, and protective efficacy. Vaccine candidates induce both neutralizing antibody response multifunctional SFTSV-specific T cell in mice ferrets. When vaccine efficacy is investigated aged-ferrets that recapitulate fatal clinical...
Background and Objectives The effectiveness of needle‐free injection devices in neocollagenesis for treating extended skin planes is an area active research. It anticipated that systems will not only be used to inject vaccines or insulin, but also greatly aid rejuvenation when aesthetic materials such as hyaluronic acid, botulinum toxin, placental extracts. There has been any specific research date examining how penetrate the a device used. In this study, we investigated material infiltrates...
Aging well has become the new target of preventative medicine, and aesthetic dermatology can contribute to this request. The polynucleotide (PN) containing products not only fill space, but improve tissue regeneration, resulting in more natural regeneration. Five Korean women received four times injections long-chain PN filler two-week intervals for skin rejuvenation. About 0.05 mL material was injected 40 points one-side cheek. pore thickness were markedly improved patients their 30s,...
There is an increasing interest in skin rejuvenation using hyaluronic acid (HA) fillers beyond the improvement of deep wrinkles and volume deficiencies, which have been primary research foci past. We conducted a pilot study sample six middle-aged male subjects. Using automatic intradermal injector with 0.020 mL material contained each injection point total 100 points, 2 non-cross-HA filler was injected into entire face at every treatment session. administered injections HA for three sessions...
Vascular compromise with impending skin necrosis is one of the most serious potential complications. Early recognition vascular occlusion and swift aggressive treatment are required to avoid any irreversible changes. However, initial symptoms a event often dismissed as simple post-procedural discomfort. If more than 3 days pass after filler injection, crust formation initiated over erythematous base along rim fibrous tissue. Due replacement normal tissues by material, healing process may...
Sarcopenia, which refers to the muscle loss that accompanies aging, is a complex neuromuscular disorder with clinically high prevalence and mortality. Despite many efforts protect against weakness atrophy, incidence of sarcopenia its related permanent disabilities continue increase. In this study, we found treatment human placental hydrolysate (hPH) significantly increased viability (approximately 15%) H 2 O ‐stimulated C2C12 cells. Additionally, while cells showed irregular morphology, hPH...
Many studies have investigated the application of micro-insulated needles with radio frequency (RF) to treat acne in humans; however, use a needle RF applicator has not yet been studied an animal model. The purpose this study was evaluate effectiveness rabbit ear (REA) model.In study, we effect selectively destroying sebaceous glands using on formation comedones induced by 50% oleic acid and intradermal injection P. acnes orifices external auditory canals rabbits. effects treatment were...
Abstract Acne vulgaris is a common condition that can have psychologically deleterious effects. Since current treatments carry the risks of antibiotic resistance or teratogenicity, novel treatment modalities are under investigation. Our study investigated efficacy intradermal radiofrequency (RF) and intense pulsed light (IPL) in acne rabbit ear model. We evaluated effectiveness IPL, RF, combination on cultured Cuticobacterium acnes strains an induced model, according to clinical outcomes as...
Abstract Atopic dermatitis (AD) is a chronic inflammatory skin disease. Skin barrier dysfunction the initial step in development of AD. Recently, exosomes have been considered as potential cell‐free medicine for defects such aging, psoriasis and wounds. The aim this study was to investigate effects human dermal fibroblast‐neonatal‐derived exosome (HDFn‐Ex) on HDFn‐Ex increased expression peroxisome proliferator activated receptor α (PPARα) alleviated 1‐chloro‐2,4‐dinitrobenzene...
BACKGROUND Despite the widespread use of botulinum toxin (BTX) injection for treatment masseter muscle hypertrophy (MMH), there is no standard option. OBJECTIVE We report efficacy and safety BTX in MMH over a period 48 weeks. METHODS In double-blinded, placebo-controlled phase 3 trials, 180 patients (randomized 1:1) received with placebo (normal saline) or prabotulinumtoxinA (48 units). Masseter thickness (at maximal clenching resting positions), 3D imaging analysis, scale grades were...
Abstract AP collagen peptides (APCPs) are enzymatically decomposed that contain tri‐peptides such as glycine‐proline‐hydroxyproline. We found APCPs increased the proliferation of both human dermal papilla cells (hDPCs) and outer root sheath (hORSCs). also stimulated secretion several growth factors, including IGFBP‐6, PDGF‐AB, PIGF VEGF in hDPCs. Moreover, enhanced phosphorylation Akt(Ser 473 ), GSK‐3β(Ser 9 ) β‐catenin(Ser 675 indicating activation GSK‐3β/β‐catenin signalling pathway. Ex...
Abstract Introduction Atopic dermatitis ( AD ) is one of the most common allergic diseases. Its prevalence has been increasing in recent decades. Socio‐economic status well‐known risk factor Objective This study was performed to investigate relationship between socio‐economic and Korean adults. Methods Data were acquired from 47 351 men women, ≥19 years age who participated Korea National Health Nutrition Examination Surveys KNHANES conducted 2007 2014. The presence based on self‐reported...
Various studies have investigated treatment for vaginal laxity with microablative fractional carbon dioxide CO2 laser in humans; however, this has not yet been studied an animal model. Herein, we evaluate the therapeutic effects of tissue remodeling mucosa using a porcine model, aim improving laxity.The enables minimally invasive and non-incisional procedures. By precisely controlling energy pulses, is sent to canal introitus area induce thermal denaturation contraction collagen. We examined...