A5044720437- Nail Diseases and Treatments
- Dermatology and Skin Diseases
- Psoriasis: Treatment and Pathogenesis
- Allergic Rhinitis and Sensitization
- Dermatologic Treatments and Research
- Botulinum Toxin and Related Neurological Disorders
- Skin Protection and Aging
- Plant Pathogens and Fungal Diseases
- Hair Growth and Disorders
- Fungal Infections and Studies
- Antifungal resistance and susceptibility
- Cutaneous lymphoproliferative disorders research
- Food Allergy and Anaphylaxis Research
- Bee Products Chemical Analysis
- Facial Rejuvenation and Surgery Techniques
- Fungal Biology and Applications
- Urticaria and Related Conditions
- Autoimmune Bullous Skin Diseases
- Acne and Rosacea Treatments and Effects
- Asthma and respiratory diseases
- Laser Applications in Dentistry and Medicine
- Contact Dermatitis and Allergies
- Consumer Perception and Purchasing Behavior
- Drug-Induced Adverse Reactions
- Ocular Surface and Contact Lens
Konkuk University
2016-2025
Konkuk University Medical Center
2016-2025
Catholic University of Korea
2011
Seoul St. Mary's Hospital
2011
BackgroundAsivatrep is a potent and selective antagonist of transient receptor potential vanilloid subfamily V member 1 (TRPV1), which plays an important role in itch inflammation atopic dermatitis (AD).ObjectiveThis current study aimed to evaluate the efficacy safety asivatrep cream patients with AD.MethodsFor this phase 3 double-blind, vehicle-controlled study, aged ≥12 years mild moderate AD were enrolled randomly assigned 2:1 1.0% or vehicle group for 8 weeks twice-daily application (n =...
Introduction & objectives Head and neck dermatitis (HND) is a refractory phenotype of atopic (AD) can be therapeutic challenge due to lack responsiveness conventional treatments. Previous studies have suggested that the microbiome fungiome may play role in inducing HND, but underlying pathogenic mechanisms remain unknown. This study aimed determine link between HND examine contribution Malassezia furfur . Materials methods To identify effect sensitization status M. on 312 patients...
Background: Seborrheic keratosis (SK) is one of the most common epidermal tumors skin.However, only a few large-scale clinicohistopathological investigations have been conducted on SK or possible correlation between histopathological subtype and location.Objective: The aim this study was to analyze clinical features relatively large number cases diagnosed SK.Methods: Two hundred seventy-one pathology slides skin tissue from patients with clinically 206 biopsy-proven were analyzed.The...
Since the treatment guidelines for atopic dermatitis (AD) were released by Korean Atopic Dermatitis Association (KADA) work group in 2006, there have been several advances AD management.We aimed to establish updated evidence- and experience-based AD.We collected a database of references from relevant systematic reviews regarding general management such as bathing skin care, avoidance exacerbating factors, education psychosocial support, use moisturizers topical anti-inflammatory antipruritic...
Background: Since the treatment guidelines for atopic dermatitis (AD) were issued by Korean Atopic Dermatitis Association (KADA) work group in 2006, there have been further advances systemic of AD.Objective: We aimed to establish updated evidence-and experience-based AD.Methods: compiled a database references from relevant systematic reviews and regarding management AD, including antihistamines, antimicrobials, immunomodulators, allergen-specific immunotherapy, phototherapy, adjunctive...
Abstract With the recent availability of culture‐independent sequencing methods, studies have been conducted to analyse skin micro‐organisms present in patients with atopic dermatitis ( AD ). However, database on fungal communities, “mycobiome,” has relatively restrictive compared bacterial world. We aimed comparatively overall mycobiome between and healthy individuals Korean population. analysed swab samples obtained from antecubital fossae 8 controls. Using method followed by direct DNA...
BACKGROUND Botulinum toxin (BTX) has been used cosmetically with good clinical efficacy and tolerable safety. OBJECTIVE This randomized, double-blind, split-face study aimed to investigate the safety of intradermal BTX in patients rosacea. MATERIALS AND METHODS Twenty-four participants were enrolled randomly given injections normal saline both cheeks. Clinician Erythema Assessment (CEA) score, Global Aesthetic Improvement Scale (GAIS) skin hydration, transepidermal water loss (TEWL), melanin...
Abstract Dandruff is known to be associated with Malassezia restricta . Zinc pyrithione (ZPT) has been used as an ingredient in anti-dandruff treatments. The mechanism of ZPT investigated several studies; however, a non-pathogenic model yeast, such Saccharomyces cerevisiae was most often used. aim the present study understand how inhibits growth M. We analyzed cellular metal content and transcriptome profile ZPT-treated cells found that treatment dramatically increased zinc levels, along...
Malassezia species are opportunistic pathogenic fungi that frequently associated with seborrhoeic dermatitis, including dandruff. Most lipid dependent, a property is compensated by breaking down host sebum into fatty acids lipases. In this study, we aimed to sequence and analyse the whole genome of restricta KCTC 27527, clinical isolate from Korean patient severe dandruff, search for lipase orthologues identify most expressed on scalp patients The M. 27527 was sequenced using Illumina MiSeq...
Malassezia species play an important role in the pathogenesis of seborrheic dermatitis. In particular, M. restricta and globosa are considered to be predominant organisms dermatitis Western countries. However, distribution has not been clearly determined yet Asia.To identify on scalp patients Korea using 26S rDNA PCR-RFLP analysis.A total 40 100 normal healthy volunteers were included this study. For identification species, scales subjects analyzed by analysis.The most commonly identified...
Summary Advances in culture‐independent sequencing methods have been utilised recent studies to understand the phylogenetic composition of human microbiome healthy and diseased skin. Allergic rhinitis ( AR ) is an inflammatory condition nasal cavity caused by environmental allergens. Although microbial communities considered important contributors health, no date comprehensively compared fungal (mycobiome) vestibule using pyrosequencing method. This study aimed investigate how skin surface...
Psoriasis is a chronic inflammatory skin disease. It assumed that the plaque phenotype of psoriasis associated with T helper (Th) 1 immune response activation, while guttate Th17 response. Previous investigations differences in serum levels cytokines relative to clinical psoriatic have yielded conflicting results. This study compared circulating and LL-37 morphological patients psoriasis. Seventy-four age-matched (32 42 psoriasis) 12 healthy controls were included. A multiplex cytokine assay...
Several studies have reported the pathogenic role of Malassezia in atopic dermatitis (AD); significance Malassezia's influence on AD needs to be further investigated. Dupilumab, a monoclonal antibody anti-Interleukin (IL) 4Rα, and ruxolitinib, Janus kinase (JAK)1/2 inhibitor, are first approved biologics inhibitors widely used for treatment. In this study, we aimed investigate how Restricta (M. restricta) affects skin barrier inflammation interacts with therapeutic agents ruxolitinib...
ABSTRACT Previous studies have shown that topical steroid and shampoo containing zinc pyrithione provide clinical benefits for treatment of scalp seborrheic dermatitis. But the efficacy tacrolimus, a newly developed calcineurin inhibitor on dermatitis, is not well investigated yet. We wanted to compare tacrolimus with conventional (zinc betamethasone) dermatitis scalp. Patients were randomly allocated receive betamethasone, or shampoo. Some patients instructed continue treatments 8 weeks...
Abstract Objective To evaluate the capacity of automatic detection system to accurately grade, from smartphones' selfie pictures, severity seven new facial signs added nine previously integrated. Methods A two‐step approach was conducted: first, check on 112 Korean women, how AI‐based grading may correlate with dermatological assessments, taken as reference; second, confirm 1140 women three ancestries (African, Asian, and Caucasian) relevance newly input signs. Results The sixteen specific...
Malassezia is the most dominant fungal genus on human skin surface and associated with various diseases including dandruff seborrheic dermatitis. Among species, restricta widely observed species skin. In current study, we identified a novel dsRNA virus, named MrV40, in M. characterized sequence structure of viral genome along an independent satellite segment. Moreover, expression genes involved ribosomal synthesis programmed cell death was altered, indicating that virus infection affected...
In 2015, the Korean Atopic Dermatitis Association (KADA) working group published consensus guidelines for treating atopic dermatitis (AD).We aimed to provide updated recommendations systemic treatment of AD in South Korea based on recent evidence and experience.We compiled a database references from relevant systematic reviews management AD. Evidence each statement was graded classified thestrength recommendation. Forty-two council members KADA participated three rounds voting establish...
Malassezia yeasts are normal flora of the skin found in 75~98% healthy subjects. The accurate identification species is important for determining pathogenesis with regard to various diseases such as folliculitis, seborrheic dermatitis, and atopic dermatitis.This research was conducted determine a more rapid molecular test classification yeasts.We compared accuracy efficacy restriction fragment length polymorphism (RFLP) nested polymerase chain reaction (PCR) yeasts.Although both methods...
Fractional photothermolysis makes thousands of minute areas called microthermal treatment zones on the skin surface and transmits thermal injury to facilitate heat shock protein formation around dermis. Potential side effects include acneiform eruption, herpes simplex virus outbreak, erythema, post-inflammatory hyperpigmentation.To investigate compare changes in Asian patients after two different fractional systems (FPS) a split face.A half-split face study was performed with 10,600 nm...
Malassezia species (spp.) are cutaneous opportunistic pathogens and associated with various dermatological diseases including seborrheic dermatitis, dandruff atopic dermatitis. Almost all spp. obligatorily lipid-dependent, which might be caused by lack of the myristic acid synthesis. Recent genome analysis M. restricta globosa suggested that absence a gene encoding fatty synthesis compensated abundant genes hydrolases, produce acids, lipases phospholipases may play role in virulence...
The aims of this study were to evaluate the prevalence, severity and risk factors for atopic dermatitis in Korean pre-school children as determined by dermatological examination vs questionnaire survey. A total 6,453 from 59 kindergartens 14 day-care centres evaluated. Parents responded an International Study Asthma Allergies Childhood (ISAAC)-based containing questions concerning 23 factors, well dermatitis. Fourteen dermatologists then examined participants according diagnostic criteria...
Malassezia restricta is an opportunistic fungal pathogen on human skin; it associated with various skin diseases, including seborrheic dermatitis and dandruff, which are usually treated using ketoconazole. In this study, we clinically isolated ketoconazole-resistant M. strains (KCTC 27529 KCTC 27550) from patients dandruff. To understand the mechanisms of ketoconazole resistance in isolates, their genomes were sequenced compared susceptible reference strain 27527. Using comparative genome...
MBA-P01 is a newly developed botulinum toxin A (BoNT-A) product designed to provide similar clinical effects as OnabotulinumtoxinA (ONA-BoNT-A), thereby providing an alternative treatment option for glabellar lines. It another holotoxin preparation containing BoNT-A1. This randomized, double-blind, active-controlled, multi-center, Phase III trial aimed evaluate the efficacy and safety of compared with (ONA-BoNT-A). In total, 318 participants were enrolled received 20 units or ONA-BoNT-A on...