A5008983906- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Outbreaks Research
- Animal Virus Infections Studies
- Vector-Borne Animal Diseases
- SARS-CoV-2 detection and testing
- Virology and Viral Diseases
- Viral Infections and Immunology Research
- Viral Infections and Vectors
- Viral gastroenteritis research and epidemiology
- Cancer Immunotherapy and Biomarkers
- interferon and immune responses
- Immune Cell Function and Interaction
- Respiratory viral infections research
- CAR-T cell therapy research
- Influenza Virus Research Studies
International Vaccine Institute
2021
Korea Research Institute of Bioscience and Biotechnology
2021
Korea Advanced Institute of Science and Technology
2018-2019
Although the incidence of severe fever with thrombocytopenia syndrome virus (SFTSV) infection has increased from its discovery a mortality rate 10-20%, no effective vaccines are currently available. Here we describe development SFTSV DNA vaccine, immunogenicity, and protective efficacy. Vaccine candidates induce both neutralizing antibody response multifunctional SFTSV-specific T cell in mice ferrets. When vaccine efficacy is investigated aged-ferrets that recapitulate fatal clinical...
The development of safe and effective vaccines to prevent SARS-CoV-2 infections remains an urgent priority worldwide. We have used a recombinant vesicular stomatitis virus (rVSV)-based prime-boost immunization strategy develop COVID-19 vaccine candidate. constructed VSV genomes carrying exogenous genes resulting in the production avirulent rVSV full-length spike protein (SF), S1 subunit, or receptor-binding domain (RBD) plus envelope (E) SARS-CoV-2. Adding honeybee melittin signal peptide...
Abstract P.1. or gamma variant also known as the Brazil variant, is one of variants concern (VOC) which appears to have high transmissibility and mortality. To explore potency CT-P59 monoclonal antibody against P.1 we tried conduct binding affinity, in vitro neutralization, vivo animal tests. In assays revealed that able neutralize spite reduction its affinity a RBD (receptor domain) mutant protein including K417T/E484K/N501Y neutralizing activity pseudoviruses live viruses. contrast, hACE2...