The aging process is a complex interplay of intrinsic and extrinsic factors across multiple layers the face. Accordingly, combining aesthetic interventions targeting different manifestations often leads to better results than single modalities alone. However, no guidelines for pan-facial approach using have been published date.To develop consensus recommendations optimal combination ideal sequence botulinum toxin (BoNT), hyaluronic acid, calcium hydroxylapatite, microfocused ultrasound with...

BACKGROUND The use of botulinum toxin has rapidly expanded into various aesthetic applications. Any guideline representing a consensus for treatments using type A (BTA) in Asians not been published. OBJECTIVES To provide recommendations on common problems which are treated by neurotoxin Asians. METHODS panel experienced Korean dermatologists was convened to develop clinical involving the face, neck, and calves Asians, based their own extensive experience. RESULTS address general questions...

Summary Background A small subgroup of atopic dermatitis (AD) patients with normal serum IgE levels and without specific sensitization has been termed ‘intrinsic type AD’ (ADi) as a counterpart to the term ‘extrinsic (ADe). However, there are neither molecular markers nor clinically diagnostic tools for distinguishing between ADi ADe. Objective The present studies were undertaken clarify pathogenesis in vivo cytokine micromilieu comparison ADe patients. Methods We used semiquantitative...

Surgical scars are a common cosmetic problem that occurs in various surgical fields including dermatology. Diverse trials have been made to prevent this annoying scar formation. Recently, 585- and 595-nm pulsed dye laser irradiation presented satisfactory outcome for the treatment of scars. Other fractionated lasers or light devices were also applied treatment.To determine effectiveness safety newly developed 1,550-nm fractional erbium-glass prevention formation after total...

The popularity of aesthetic procedures in the face has led to greater disparity between treated areas and those that still show evidence true age. Although many body often require multiple treatment for optimal rejuvenation, combination therapy specific is not yet well defined.To develop recommendations ideal sequence botulinum toxin (BoNT), hyaluronic acid, calcium hydroxylapatite (CaHA), microfocused ultrasound with visualization nonfacial across all skin phototypes.Fifteen specialists...

Skin boosters denote injectables that promote global improvement of the skin which includes texture, elasticity, hydration, and overall appearance. Polynucleotide (PN) products have become popular, but there is surprisingly little guidance on their use. We aimed to maximize safety efficacy injectable PN by providing information pattern practice among board-certified dermatologists.

Background: Botulinum neurotoxin type A (BoNTA) is widely used in aesthetic facial rejuvenation medicine. The exponential growth using BoNTA for cosmetic purposes Korea necessitates an update to the existing practice guidelines, building upon consensus established by Korean experts 2013. Aims: This work aims provide updated guideline safe and effective use of a novel product (NEWLUX) expression muscles. Methods: panel ten dermatology, plastic surgery, medicine, clinical anatomy convened...

Quantitative measurements are important for objective evaluation of postprocedural outcomes. Three-dimensional (3D) imaging is known as an objective, accurate, and reliable system quantifying the soft tissue dimensions face.To compare preprocedural acute nasofrontal, nasofacial, nasolabial, nasomental angles, early changes in height length nose, nasal volume using a 3D surface with light-emitting diode.The analysis 40 Korean women who underwent structured nonsurgical rhinoplasty was...

Aging well has become the new target of preventative medicine, and aesthetic dermatology can contribute to this request. The polynucleotide (PN) containing products not only fill space, but improve tissue regeneration, resulting in more natural regeneration. Five Korean women received four times injections long-chain PN filler two-week intervals for skin rejuvenation. About 0.05 mL material was injected 40 points one-side cheek. pore thickness were markedly improved patients their 30s,...

It is well known that skin aging related to the destruction of collagen and elastin fibers by metalloproteinases (MMPs). Aged fibroblasts have a decreased ability synthesize elastin. Nuclear factor erythroid 2-related 2 (NRF2) involves glyoxalase (GLO) activation, which inhibits production advanced glycated end products (AGE) expression its receptor (RAGE). RAGE increases nuclear transcription factor-kappa B (NF-κB), upregulates MMPs decreases elasticity. NRF2 also M1 macrophages, secrete...

The study aimed to compare the volume enhancement and lifting capacity of two different hyaluronic acid gels for lip injection. Thirty-six Korean female patients were randomized into groups according cross-linking degree filler injected. Using a fixed injection protocol, injected with 1 mL in lips followed up at four 12 weeks after Lip volume, projection, columella-labial angle measured using 3-dimensional imaging system each time point. Follow-up values compared baseline. Compared...

Abstract The etiology and pathophysiology of delayed inflammatory reactions caused by hyaluronic acid fillers have not yet been elucidated. Previous studies suggested that the can be attributed to filler itself, patient's immunological status, infection, injection technique. Hyaluronic are composed high-molecular weight acids chemically cross-linked using substances such as 1,4-butanediol diglycidyl ether (BDDE). mechanism which BDDE cross-links two disaccharides is still unclear it may...

The injection of botulinum toxin is now commonly used for many therapeutic and cosmetic purposes but because its increased use more adverse events are being reported.To retrospectively evaluate analyze the safety injections in terms purpose type administered.Data were collected on 1819 patients who underwent a total 5310 treatments between 2005 2011 at single tertiary medical center. Information dosage, treatment purpose, toxin, any associated with these analyzed. generalized estimating...

Abstract Background In any dermatologic procedure, patient acceptance of treatment is heavily influenced by intraprocedural pain. Intralesional triamcinolone injections are very important in keloid scar and nodulocystic acne treatment. However, the main problem needle‐stick procedures Cryoanesthesia ideally intended to cool only epidermis during has advantage which did not require application time. Aims The aim this study was investigate pain‐reducing effect safety CryoVIVE® (newly...

Abstract Aging-related changes in the skin, such as dullness, dehydration, and loss of elasticity, significantly affect its appearance integrity. Injectable “skin boosters,” comprising various biological materials, have become increasingly prominent addressing these issues, offering rejuvenation revitalization. This review offers a comprehensive examination injectables, detailing their types, mechanisms action, clinical uses. It also evaluates evidence for effectiveness safety treating...

Background There is a subgroup of atopic dermatitis (AD) patients with normal total and specific IgE levels negative skin tests towards common allergens. This form the disease has been referred to as ‘intrinsic’ AD. Although previous studies have demonstrated differences in cytokine profile between extrinsic intrinsic subtypes, pathogenesis both subtypes AD remains unclear. Objectives To compare inflammatory micromilieu forms Methods Immunophenotyping cells was performed lesional nonlesional...

Although hyaluronic acid (HA) filler injections are associated with various non-vascular inflammatory complications, the underlying mode of action remains unclear. The may not be sufficiently pure, leading to an immune response. present study attempted identify any impurities in fillers available on market. Particles were counted after degrading hyaluronidase. Particulate matter was subsequently observed using scanning electron microscopy, and particle components evaluated energy-dispersive...

The efficacy and safety of botulinum toxin injection have made it a popular aesthetic procedure worldwide. A cross-sectional survey was performed in order to determine the pattern type injections cosmetic practice, for which an 18-item questionnaire distributed dermatologists. total 469 Korean board-certified dermatologists participated survey, with following results: main candidates were individuals their 40-50 years (46.1%), followed by those 20-30 (33.4%), people over 60 age (20.5%)....

Journal Article Calcified nodule on the heel of a child following single stick in neonatal period Get access N.‐K. Rho, Rho Department Dermatology, Samsung Medical Center, Sungkyunkwan University School Medicine, Seoul, Korea Search for other works by this author on: Oxford Academic Google Scholar S.‐J. Youn, Youn H.‐S. Park, Park W.‐S. Kim, Kim E.‐S. Lee Lee, 50 Ilwon‐dong, Kangnam‐ku, Seoul 135–710, Korea. Tel.: +82 2 3410 6577. Fax: 3869. E‐mail: eslee@smc.samsung.co.kr Clinical and...