A5021865337- Dermatologic Treatments and Research
- Cutaneous lymphoproliferative disorders research
- melanin and skin pigmentation
- Skin Protection and Aging
- Lymphoma Diagnosis and Treatment
- Cancer and Skin Lesions
- Cutaneous Melanoma Detection and Management
- Nail Diseases and Treatments
- Nonmelanoma Skin Cancer Studies
- Genetic and rare skin diseases.
- Facial Rejuvenation and Surgery Techniques
- Dermatology and Skin Diseases
- Biochemical Analysis and Sensing Techniques
- Acne and Rosacea Treatments and Effects
- Hair Growth and Disorders
- Vascular Tumors and Angiosarcomas
- Sarcoma Diagnosis and Treatment
- Laser Applications in Dentistry and Medicine
- Autoimmune Bullous Skin Diseases
- Viral-associated cancers and disorders
- Soft tissue tumor case studies
- Fungal Infections and Studies
- Autoimmune and Inflammatory Disorders
- Cancer Diagnosis and Treatment
- Tumors and Oncological Cases
Ulsan College
2016-2025
University of Ulsan
2016-2025
Asan Medical Center
2016-2025
Anna Needs Neuroblastoma Answers
2021
GTx (United States)
2018
Hanyang University
2016
American Academy of Dermatology
2014
College of Charleston
2014
International Psychogeriatric Association
2012
Faculty (United Kingdom)
2012
Although there have been reports of the successful diagnosis skin disorders using deep learning, unrealistically large clinical image datasets are required for artificial intelligence (AI) training. We created standardized nail images a region-based convolutional neural network (R-CNN) trained to distinguish from background. used R-CNN generate training 49,567 images, which we then fine-tune ResNet-152 and VGG-19 models. The validation comprised 100 194 Inje University (B1 B2 datasets,...
Background and Study Aims: Intestinal tuberculosis Crohn's disease are chronic inflammatory bowel disorders that difficult to differentiate from one another. This study aimed evaluate the diagnostic value of various colonoscopic findings in differential diagnosis between intestinal disease. Patients Methods: Colonoscopic on initial work-up were prospectively recorded patients with an either or These analyzed after a final (n = 44) had been made follow-up. Results: Four parameters (anorectal...
Detection of cutaneous cancer on the face using deep-learning algorithms has been challenging because various anatomic structures create curves and shades that confuse algorithm can potentially lead to false-positive results.To evaluate whether an automatically locate suspected areas predict probability a lesion being malignant.Region-based convolutional neural network technology was used 924 538 possible lesions by extracting nodular benign from 182 348 clinical photographs. After manually...
Abstract The incidence of infections caused by non‐tuberculous mycobacteria has increased in recent years, due to a rise dermatological procedures and greater prevalence immunosuppression the general population. This study investigated clinical microbiological findings mycobacterial skin infections. population included 29 patients from whom were cultured after isolation biopsy materials, cutaneous abscesses or exudates. Clinical, epidemiological data collected each patient. Eight...
Regulation of melanogenesis has been the focus treatment for hyperpigmentary skin disorders. Although hesperidin is one most well-known, naturally occurring flavonoids with antioxidant and anti-inflammatory effect, its anti-melanogenic effect not known. The present study aims to determine hespiridin as well underlying molecular mechanisms. Melanin contents were measured in normal human melanocytes B16F10 melanoma cells. Protein mRNA levels tyrosinase, microphthalmia-associated transcription...
Striae distensae are dermal scars characterized by flattening and atrophy of the epidermis. Although many treatment modalities have been tried with variable results, most disappointing.To determine whether striae might respond to fractional photothermolysis.Twenty-two women were treated two sessions each photothermolysis at a pulse energy 30 mJ, density level 6, eight passes intervals 4 weeks. Response was assessed comparing pre- post-treatment clinical photography skin biopsy samples.Six 22...
BACKGROUND Epidermal growth factor (EGF) is a peptide that promotes cell by binding to its receptor (EGFR) on the surface. EGF has been used in cosmetics whiten skin and for prevention of postinflammatory hyperpigmentation (PIH), presumably accelerating wound healing, but effects melanogenesis are not known, presence EGFR melanocytes confirmed. METHODS To establish role melanogenesis, we first investigated expression melanocytes. Second, search an effect PIH, melanin production with or...
Ginseng has been shown to promote hair growth in several recent studies. However, its effects on human follicles and mechanisms of action have not sufficiently elucidated. This study aimed investigate the growth-promoting red ginseng extract (RGE) ginsenosides. The proliferative activities cultured treated with RGE ginsenoside-Rb1 were assessed using Ki-67 immunostaining. Their isolated dermal papilla cells (hDPCs) evaluated cytotoxicity assays, immunoblot analysis signaling proteins,...
Abstract Although autophagy plays a role in melanogenesis by regulating melanosome degradation and biogenesis melanocytes, detailed understanding of the regulatory functions factors is lacking. Here, we report mechanistic link between microtubule-associated protein light chain 3 (LC3) activation melanogenesis. We observed high expression LC3 melanosome-associated pigment-rich melanocytic nevi sun-exposed skin, as indicated patterns melanosomal MART1 expression. Rapamycin-induced...
Background:The treatment of post-inflammatory hyperpigmentation (PIH) remains challenging.Tranexamic acid, a well-known anti-fibrinolytic drug, has recently demonstrated curative effect towards melasma and ultraviolet-induced PIH in Asian countries.However, the precise mechanism its inhibitory on melanogenesis is not fully understood.Objective: In order to clarify tranexamic acid PIH, we investigated effects mouse melanocytes (i.e., melan-a cells) human melanocytes.Methods: Melan-a cells...
Large population-based studies investigating the risks of overall and specific cancers among patients with hidradenitis suppurativa (HS) are limited.To assess cancer in HS compared without Republic Korea.A nationwide cohort study, using Korean Health Insurance Review Assessment Service database was conducted over a 2-year period from January 1, 2007, to December 31, 2008. Individuals control group who were never diagnosed or during washout randomly extracted matched by age, sex, index year,...
Melanogenesis is a critical self-defense mechanism against ultraviolet radiation (UVR)-induced skin damage and carcinogenesis; however, dysregulation of melanin production distribution causes skin-disfiguring pigmentary disorders.Melanogenesis initiated by UVR-induced cAMP generation ensuing activation transcription factor CREB, which induces expression the master melanogenic regulator MITF.Recent studies have demonstrated that recruitment CRTCs to CREB complex also required for...
Abstract V-domain Ig suppressor of T-cell activation (VISTA), which mediates immune evasion in cancer, is mainly expressed on hematopoietic cells and myeloid the tumor. We evaluated correlations among expression VISTA, myeloid-derived cell marker CD33, programmed death-1 (PD-1), determined their relationships with clinicopathological characteristics disease outcomes melanoma. Diagnostic tissue from 136 cases melanoma was by immunohistochemistry for PD-1 expression. Dual immunofluorescence...
Background The diagnostic performance of convolutional neural networks (CNNs) for diagnosing several types skin neoplasms has been demonstrated as comparable with that dermatologists using clinical photography. However, the generalizability should be a large-scale external dataset includes most neoplasms. In this study, network algorithm was compared in both real-world practice and experimental settings. Methods findings To demonstrate generalizability, cancer detection (...