A5015308460- melanin and skin pigmentation
- Dermatology and Skin Diseases
- Biochemical Analysis and Sensing Techniques
- Nail Diseases and Treatments
- Skin and Cellular Biology Research
- Allergic Rhinitis and Sensitization
- Skin Protection and Aging
- Protein Structure and Dynamics
- Cutaneous lymphoproliferative disorders research
- Cancer and Skin Lesions
- Asthma and respiratory diseases
- Phytochemicals and Antioxidant Activities
- Food Allergy and Anaphylaxis Research
- Autoimmune Bullous Skin Diseases
- Enzyme function and inhibition
- Hair Growth and Disorders
- Natural Antidiabetic Agents Studies
- Enzyme Structure and Function
- Mobile Ad Hoc Networks
- Olfactory and Sensory Function Studies
- Dermatologic Treatments and Research
- Wound Healing and Treatments
- Genetic and rare skin diseases.
- Muscle metabolism and nutrition
- Urticaria and Related Conditions
Yonsei University
2020-2023
Asan Medical Center
2022
University of Ulsan
2022
Ulsan College
2022
Sungkyunkwan University
2012-2021
Samsung Medical Center
2012-2021
Samsung (South Korea)
2001-2019
Kangbuk Samsung Hospital
2019
National NanoFab Center
2007-2016
Tsinghua University
2014
Background: Staphylococcus aureus (SA) has peculiar abilities to colonize the skin in atopic dermatitis (AD) patients.Objective: We sought determine colonization rates of SA acute and chronic lesions AD patients, find any difference according age influences total immunoglobulin E (IgE) eosinophil counts SA.Methods: evaluated IgE level counts, cultured from 687 patients (131 556 lesions) 247 control urticaria (July 2009 November 2010; Samsung Medical Center Dermatology Clinic, Seoul,...
Abstract Tyrosinase inhibition studies have recently gained the attention of researchers due to their potential application values. We simulated docking (binding energies for AutoDock Vina: −9.1 kcal/mol) and performed a molecular dynamics simulation verify results between tyrosinase rutin. The suggest that rutin mostly interacts with histidine residues located in active site. A 10 ns showed one copper ion at site was responsible interaction Kinetic analyses rutin-mediated inactivation...
Summary Background A small subgroup of atopic dermatitis (AD) patients with normal serum IgE levels and without specific sensitization has been termed ‘intrinsic type AD’ (ADi) as a counterpart to the term ‘extrinsic (ADe). However, there are neither molecular markers nor clinically diagnostic tools for distinguishing between ADi ADe. Objective The present studies were undertaken clarify pathogenesis in vivo cytokine micromilieu comparison ADe patients. Methods We used semiquantitative...
The transglutaminase 3 enzyme is expressed during the late stages of terminal differentiation epidermis and in certain cell types hair follicle. thought to be critically involved cross-linking structural proteins formation cornified envelope, thereby contributing rigid structures that play vital roles shape determination and/or barrier functions. To explore mechanisms regulating expression gene (TGM3), 3.0 kilobase pairs sequences upstream from transcription start site were assessed for...
Abstract: Th2-dominated immune responses are believed to contribute the pathogenesis of atopic dermatitis (AD). IL-4 and IL-13 typical pleiotropic Th2 cytokines that play a central role in IgE-dependent inflammatory reactions. Single-nucleotide polymorphisms (SNPs) have been reported patients with allergic disease from numerous countries. Gene–gene interactions among genes identified asthma, although negative results reported. To investigate associations SNPs these between AD, we genotyped...
Many alpha-helical proteins that form two-chain coiled coils possess a 13-residue trigger motif seems to be required for the stability of coil. However, as currently defined, is absent from intermediate filament (IF) protein chains, which nevertheless segmented coils. In present work, we have searched and identified two regions in IF chains are essential necessary formation coiled-coil molecules thus may function motifs. We made series point substitutions with keratin 5/keratin 14 system....
Background: Eosinophils are recruited into the affected tissue of asthma and atopic dermatitis (AD) patients. IL‐5 IL‐5R highly expressed in AD skin lesions, yet reported levels IL‐8 controversial. Method: We genotyped 17 singlenucleotide polymorphisms (SNPs) from five genes 1120 case‐control samples (646 474 controls). measured serum concentrations 87 individuals [36 ADe (AD extrinsic), 18 ADi intrinsic) 33 controls] by ELISA, compared results among these groups. Result: The rs2522411SNP...
Comparison of Transepidermal Water Loss
Fucoidan is a complex sulfated polysaccharide extracted from brown seaweed and has wide variety of biological activities. In this study, we investigated the inhibitory effect fucoidan on tyrosinase via combination inhibition kinetics computational simulations. reversibly inhibited in mixed-type manner. Time-interval showed that was processed as first order with biphasic processes. For further insight, simulated dockings various sizes molecular models (monomer to decamer) best binding energy...
Atopic dermatitis (AD) is a chronic relapsing inflammatory skin disease typically characterized by distribution of eczematous lesions with lichenification, pruritic excoriations, and dry wide varieties pathophysiologic aspects. Recently, AD was divided into extrinsic intrinsic forms according to the presence or absence an allergy. We investigated alterations in protein expression primary cultured cells from patient biopsy samples two-dimensional gel electrophoresis (2-DE) matrix-assisted...