A5103187851- Dermatology and Skin Diseases
- melanin and skin pigmentation
- Hair Growth and Disorders
- Acne and Rosacea Treatments and Effects
- Dermatologic Treatments and Research
- Skin Protection and Aging
- Nail Diseases and Treatments
- Cancer and Skin Lesions
- Cutaneous lymphoproliferative disorders research
- Autoimmune Bullous Skin Diseases
- Immune Response and Inflammation
- Advancements in Transdermal Drug Delivery
- Genetic and rare skin diseases.
- Herpesvirus Infections and Treatments
- Skin and Cellular Biology Research
- Autoimmune and Inflammatory Disorders
- Psoriasis: Treatment and Pathogenesis
- Immunotherapy and Immune Responses
- Wnt/β-catenin signaling in development and cancer
- Contact Dermatitis and Allergies
- Oral Health Pathology and Treatment
- Hedgehog Signaling Pathway Studies
- RNA regulation and disease
- Cancer Cells and Metastasis
- Pharmacological Effects of Natural Compounds
Korea National University of Education
2024
Stanford Medicine
2023
Chungnam National University Hospital
2011-2021
Chungnam National University
2008-2020
Korea Institute of Oriental Medicine
2016
Recently, autologous platelet-rich plasma (PRP) has attracted attention in various medical fields, including plastic and orthopedic surgery dermatology, for its ability to promote wound healing. PRP been tested during facelift hair transplantation reduce swelling pain increase density.To investigate the effects of on growth using vivo vitro models.PRP was prepared double-spin method applied dermal papilla (DP) cells. The proliferative effect activated DP cells measured. To understand...
Background: Aquaporins (AQPs) are a family of water transporting proteins present in many mammalian epithelial and endothelial cell types.Among the AQPs, AQP3 is known to be water/glycerol transporter expressed human skin.Objective: The relationship between expression level transpidermal loss (TEWL) lesional peri-lesional skin psoriasis-affected patients, hydration psoriasis was investigated.Methods: healthy control determined using immunohistochemical immunofluroscence staining.TEWL were...
Background Vitamin D plays an important role in the immune system, and its deficiency has been implicated various skin diseases, including atopic dermatitis psoriasis. Acne is a common inflammatory disease; however, association with vitamin remains unclear. Objectives We evaluated levels patients acne to determine effect of supplementation. Methods This study included 80 healthy controls. Serum 25-hydroxyvitamin (25(OH)D) were measured, demographic data collected. D-deficient treated oral...
Imiquimod is known to exert its effects through Toll-like receptor 7 (TLR7) and/or TLR8, resulting in expression of proinflammatory cytokines and chemokines. Keratinocytes have not been reported constitutively express TLR7 the action imiquimod thought be mediated by adenine receptor, or TLR8. In this study, we revealed keratinocytes after calcium-induced differentiation. After addition calcium cultured keratinocytes, immunological responses induced imiquimod, such as activation NF-κB...
Nrf2 plays a role in protection of cells against oxidative stress and xenobiotic damage by regulating cytoprotective genes. In this study, we investigated the effect on melanogenesis normal human melanocytes (NHMCs). When NHMCs were transduced with recombinant adenovirus expressing Nrf2, melanin synthesis was significantly decreased. Consistent result, overexpression decreased expression tyrosinase tyrosinase-related protein 1. The inhibitory reversed Keap1, an intracellular regulator Nrf2....
In this study, we investigated the expression and putative role of Sox9 in epidermal keratinocyte. Immunohistochemical staining showed that is predominantly expressed basal layer normal human skin epidermis, highly several diseases including psoriasis, cell carcinoma, keratoacanthoma squamous carcinoma. calcium-induced keratinocyte differentiation model, was decreased a time dependent manner. When overexpressed using recombinant adenovirus, growth enhanced, while differentiation-related...
Background: Atopic dermatitis (AD) patients suffer from xerosis.Proper skin care, including the use of emollients, may help improve xerosis and minimize disease exacerbation.Lactobacillus sakei probio 65, isolated Korean vegetable-based product kimchi, can decrease interleukin 4 immunoglobulin E levels inhibit Staphylococcus aureus.Moreover, it has reportedly shown positive dermatological effects in both animal clinical studies.Objective: To compare an emollient that contains Lactobacillus...
BACKGROUND Laser and light-based therapies have been used successfully in the treatment of rosacea; however, evidence is lacking regarding efficacy radiofrequency (RF). OBJECTIVE This study evaluated RF rosacea compared with pulsed dye laser (PDL). METHODS Thirty patients (erythematotelangiectatic [ETR], n = 20; papulopustular [PPR], 10) were enrolled a randomized, controlled, split-face study. The treated on one side PDL other side. Each consisted 3 sessions at 4-week intervals followed up...
Many treatments induce remission in patients with alopecia areata. Systemic steroids, for example, are effective the treatment of severe areata but have many side-effects. To avoid these side-effects, high-dose bolus infusions methylprednisolone been used to treat The purpose this study was evaluate prognostic factors associated pulse therapy and establish proper indications therapy. Seventy were treated i.v. on 3 consecutive days. All had rapid extensive hair loss bald area exceeding 50%...
Imiquimod, a nucleoside analogue of the imidazoquinoline family, is being used to treat various cutaneous cancers including squamous cell carcinoma (SCC). Imiquimod activates anti-tumor immunity via Toll-like receptor 7 (TLR7) in macrophage and other immune cells. can also affect tumor cells directly, regardless its impact on system. In this study, we demonstrated that imiquimod induced apoptosis SCC (SCC12) A20 was involved process. When overexpressed, imiquimod-induced markedly inhibited....
Adiponectin plays important roles in metabolic function, inflammation and multiple biological activities various tissues. However, evidence for adiponectin signaling sebaceous glands is lacking, its role remains to be clarified. This study investigated the of lipid production an experimental human sebocytes. We demonstrated that vivo sebocytes vitro express receptor increased cell proliferation. Moreover, based on a lipogenesis using Oil Red O, Nile red staining thin layer chromatography,...
Abstract Background Isotretinoin has been frequently used for acne therapy. However, it limitation in acceptance because of its adverse effects. Although antihistamine recently revealed to decrease the lipogenesis, evidence is lacking regarding clinical relevance treatment acne. Objectives To evaluate efficacy and tolerability as an adjuvant isotretinoin. Methods Forty patients with moderate were included this randomized, controlled comparative study. Twenty treated isotretinoin 20...
Abstract Alopecia areata (AA), a chronic, relapsing, hair-loss disorder, is considered to be T cell-mediated autoimmune disease. It affects approximately 1.7% of the population, but its precise pathogenesis remains elucidated. Despite recent attention focused on roles inflammasomes in autoinflammatory diseases, little known about inflammasome activation AA. Thus, this study, we investigated pattern NLRP3 outer root sheath (ORS) cells hair follicles. We found that interleukin (IL)-1β and...