A5101644897- Dermatology and Skin Diseases
- Acne and Rosacea Treatments and Effects
- Psoriasis: Treatment and Pathogenesis
- Hair Growth and Disorders
- melanin and skin pigmentation
- Dermatologic Treatments and Research
- Cancer and Skin Lesions
- Genetic and rare skin diseases.
- Asthma and respiratory diseases
- Plant Pathogens and Fungal Diseases
- Chronic Kidney Disease and Diabetes
- Fungal Infections and Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Autophagy in Disease and Therapy
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Renal Diseases and Glomerulopathies
- Skin Protection and Aging
- Nanoplatforms for cancer theranostics
- Photodynamic Therapy Research Studies
- Sympathectomy and Hyperhidrosis Treatments
- Skin and Cellular Biology Research
- Yeasts and Rust Fungi Studies
- Dermatological and Skeletal Disorders
- Porphyrin and Phthalocyanine Chemistry
- Heme Oxygenase-1 and Carbon Monoxide
Capital Medical University
2025
The University of Texas at Arlington
2023-2024
Zhongnan Hospital of Wuhan University
2024
Wuhan University
2024
Sixth Affiliated Hospital of Sun Yat-sen University
2021-2024
Sun Yat-sen University
2021-2024
Zhuhai People's Hospital
2024
Shaoxing People's Hospital
2014-2023
Tohoku University
2022
Guangdong Medical College
2012-2021
The scaffolding adaptor protein p62/SQSTM1 (p62) has been shown to be an autophagy receptor that acts as a link between the ubiquitination and machineries. However, roles of p62 in human keratinocytes are not well understood. In this study, we show keratinocyte negatively regulates expression, which is essential for prevention excessive inflammation induction cathelicidin keratinocytes. Stimulation TLR2/6 or TLR4 primary robustly activated pathways up-regulated expression through NADPH...
Ru(II) polypyridyl complexes have gained widespread attention as photosensitizers for photodynamic therapy (PDT). Herein, we systematically investigate a series of the type [Ru(phen)2(IP-nT)]2+, featuring 1,10-phenanthroline (phen) coligands and imidazo[4,5-f][1,10]phenanthroline ligands tethered to n = 0-4 thiophene rings (IP-nT). The were characterized investigated their electrochemical, spectroscopic, (photo)biological properties. electrochemical oxidation nT unit shifted by -350 mV 1 → 4...
Imiquimod is known to exert its effects through Toll-like receptor 7 (TLR7) and/or TLR8, resulting in expression of proinflammatory cytokines and chemokines. Keratinocytes have not been reported constitutively express TLR7 the action imiquimod thought be mediated by adenine receptor, or TLR8. In this study, we revealed keratinocytes after calcium-induced differentiation. After addition calcium cultured keratinocytes, immunological responses induced imiquimod, such as activation NF-κB...
In this study, we investigated the expression and putative role of Sox9 in epidermal keratinocyte. Immunohistochemical staining showed that is predominantly expressed basal layer normal human skin epidermis, highly several diseases including psoriasis, cell carcinoma, keratoacanthoma squamous carcinoma. calcium-induced keratinocyte differentiation model, was decreased a time dependent manner. When overexpressed using recombinant adenovirus, growth enhanced, while differentiation-related...
Abstract Forkhead box‐O1 (FoxO1) is a key nutrient‐ and growth factor‐dependent regulator of metabolism, but its functional role in human primary keratinocytes ( HPK s) less known. To investigate the FoxO1 s effect insulin‐like factor 1 IGF ‐1) isotretinoin on expression, were treated with 1.2 mmol/L calcium chloride, 1‐20 ng/mL ‐1 0.1‐10 μmol/L isotretinoin. Recombinant adenovirus expressing or FKHR sh RNA lentivirus transfection was introduced to upregulate silence expression. Epidermal...
Abstract This study employs TLD1433, a Ru II ‐based photodynamic therapy (PDT) agent in human clinical trials, as benchmark to establish protocols for studying the excited‐state dynamics of photosensitizers (PSs) cellulo , local environment provided by cancer cells. Very little is known about properties any PS live cells, and it terra incognita . contribution targets general problem phototherapy, which how interrogate light‐triggered, function‐determining processes PSs relevant biological...
Emodin, a natural anthraquinone derivative, possesses anti-proliferative and anti-inflammatory properties in skin diseases. However, little information is available on the efficacy of emodin treating acne vulgaris (acne). This study aims to investigate protective effects potential mechanisms as an anti-acne agent. In vitro, SZ95 sebocytes was chose establish acneigenic cellular model. We found that effectively inhibited proliferation, induced cell cycle arrest apoptosis dose-dependent...
Abstract Aim This study aims to investigate α‐fetoprotein (AFP) trajectories for prediction of survival outcomes after hepatic arterial infusion chemotherapy (HAIC) treatment in large hepatocellular carcinoma (HCC). Methods From May 2014 June 2020, 889 eligible patients with HCC underwent HAIC were retrospectively enrolled from five hospitals. A latent class growth mixed (LCGM) model was applied distinguish potential AFP level dynamic changing trajectories. Inverse‐probability‐of‐treatment...
Toxoplasma gondii is an obligate intracellular parasite that stimulates production of high levels proinflammatory cytokines, which are important for innate immunity. NLRs, i.e., nucleotide-binding oligomerization domain (NOD)-like receptors, play a crucial role as immune sensors and form multiprotein complexes called inflammasomes, mediate caspase-1-dependent processing pro-IL-1β. To elucidate the inflammasome components in T. gondii-infected THP-1 macrophages, we examined...
Autophagy and apoptosis are critical for controlling Toxoplasma gondii (T. gondii) infection. T. infection during pregnancy can damage the fetus cause birth defects; however, molecular mechanisms of this process poorly understood. This study aims to determine activities autophagy as well their regulatory by using human umbilical cord mesenchymal stem cells (hUC-MSCs) a model congenital diseases. LC3B, hallmark protein was incrementally upregulated with duration, whereas p62 downregulated in...
Tuberculosis is chronic respiratory infectious disease and caused by the infection of Mycobacterium tuberculosis (M.tb). Macrophages play an important role in host immune response against M.tb infection, which regulated various factors, including microRNAs (miRNAs). The present study aimed to examine vitro functional miR-1178 mycobacterial survival inflammatory responses induced human macrophages. Our results showed that increased expression macrophages (HTP-1 U937 cells) a concentration-...
Abstract Genome‐wide association studies have found the single nucleotide polymorphism ( SNP ) c.C2458T, at caspase recruitment domain family member 14 CARD gene, to be associated with psoriasis. But little is known about of c.C2458T and clinical features psoriasis vulgaris (PsV) in a Chinese cohort. This study was undertaken further explore relationship between risk southern subjects evaluate effect on A case–control performed involving 345 PsV patients 206 controls. The variant typed using...
Hepatic arterial infusion chemotherapy (HAIC) using the FOLFOX regimen (oxaliplatin plus fluorouracil and leucovorin) is a promising option for large hepatocellular carcinoma (HCC). However, post-HAIC prognosis can vary in different patients due to tumor heterogeneity. Herein, we established two nomogram models assess survival of after HAIC combination therapy.A total 1082 HCC who underwent initial were enrolled between February 2014 December 2021. We built prediction: preoperative...