A5100458978- Genetic Syndromes and Imprinting
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Animal Genetics and Reproduction
- Prenatal Screening and Diagnostics
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Reproductive Biology and Fertility
- Renal and related cancers
- CRISPR and Genetic Engineering
- RNA Research and Splicing
- Genetic Mapping and Diversity in Plants and Animals
- Psoriasis: Treatment and Pathogenesis
- Galectins and Cancer Biology
- Asthma and respiratory diseases
- Histone Deacetylase Inhibitors Research
- Mycotoxins in Agriculture and Food
- Estrogen and related hormone effects
- Cancer, Hypoxia, and Metabolism
- Dermatology and Skin Diseases
- RNA and protein synthesis mechanisms
- Hair Growth and Disorders
- Birth, Development, and Health
- Skin and Cellular Biology Research
Gansu Agricultural University
2021-2025
Hebei Agricultural University
2014-2024
Xinxiang Medical University
2024
Chengdu Second People's Hospital
2024
Chengdu University of Traditional Chinese Medicine
2023
Jilin Academy of Agricultural Sciences
2020
Union Hospital
2015-2019
Jilin University
2017-2019
Guangdong Medical College
2014-2018
Henan University Huaihe Hospital and Huaihe Clinical Institute
2017
The mammary gland consists of a branched ductal system comprised milk-producing epithelial cells that form ductile tubules surrounded by myoepithelial cell layer provides contractility required for milk ejection.Myoepithelial bear striking resemblance to smooth muscle cells, but they are derived from different embryonic lineage, and little is known the mechanisms control their differentiation.Members myocardin family transcriptional coactivators cooperate with serum response factor activate...
Long non-coding RNA FOXD2 Adjacent Opposite Strand 1 (FOXD2-AS1) has been widely reported to be implicated in the progression and recurrence of several cancers. The clinical significance functional role FOXD2-AS1 thyroid carcinoma remain unknown. expression was evaluated by analyzing cancer sequencing dataset from Cancer Genome Atlas (TCGA). In vitro vivo assays were performed assess biological roles cells. Western blot, luciferase, immunoprecipitation (IP) (RIP) used identify underlying...
Highland animals have unique hair growth mechanisms to allow them adapt harsh living environments. Compared with other species, their cycle is affected by more environmental factors. Yaks, as highland animals, obvious periodic characteristics in a year; this biological process regulated numerous proteins, but the specific molecular regulatory mechanism still unclear. Here we analyzed histological of yak follicles (HFs) at each stage and conducted TMT proteomics research. The protein...
Cloning by somatic nuclear transfer is an inefficient process in which some of the cloned animals die shortly after birth and display organ abnormalities. In effort to determine possible genetic causes neonatal death abnormalities, we used real-time quantitative reverse transcription-polymerase chain reaction examine expression patterns eight developmentally important genes (PCAF, Xist, FGFR2, PDGFRa, FGF10, BMP4, Hsp70.1, VEGF) six organs (heart, liver, spleen, lung, kidney, brain) both...
Cyclooxygenase (COX), a rate-limiting enzyme that produces prostaglandins (PGs) from arachidonic acid, exists in two isoforms, COX-1 and COX-2. PGE2 synthase (PGES) is terminal prostanoid can enzymatically convert the cyclooxygenase product PGH2 to PGE2, including isoforms: microsomal PGES (mPGES) cytosolic (cPGES). cPGES predominantly linked with promote immediate response. mPGES preferentially coupled inducible COX-2 delayed generation. COX-2-deficient female mice are infertile...
Abstract Cloning by somatic nuclear transfer is an inefficient process in which many of the cloned animals die shortly after birth and display organ abnormalities. In effort to determine possible roles IGFs played neonatal death abnormalities, we have examined expression patterns eight genes insulin‐like growth factor (IGF) systems ( IGF1, IGF2, IGF1R, IGF2R, IGFBP‐1, IGFBP‐2, IGFBP‐3, IGFBP‐4 ) six organs (heart, liver, spleen, lung, kidney, brain) both bovines (n = 9) normal control calves...
Ear rot is a globally prevalent class of disease in maize, which Fusarium ear (FER), caused by the fungal pathogen verticillioides, most commonly reported. In this study, three F 2 populations, namely -C, -D, and -J, their corresponding 2:3 families were produced crossing highly FER-resistant inbred lines, Cheng351, Dan598, JiV203, with same susceptible line, ZW18, for quantitative trait locus (QTL) mapping FER resistance. The individual crop plants inoculated spore suspension injected into...
Colorectal cancer has become a disease with one of the highest incidence rates worldwide, and liver metastasis threatens prognosis colorectal cancer. MicroRNA (miR)‑200 miR‑141 have been confirmed to be aberrantly expressed in cancer, however, whether miR‑200 are involved progression their role remain fully elucidated. The aim present study was investigate patients. A total 380 patients were enrolled, which 142 diagnosed grade I/II 238 III/IV disease. Reverse transcription‑quantitative...
The CDKN1C gene encodes a cyclin-dependent kinase inhibitor and is one of the key genes involved in development Beckwith–Wiedemann syndrome cancer. In this study, using direct sequencing approach based on single nucleotide polymorphism (SNP) at genomic DNA cDNA levels, we show that exhibits monoallelic expression all seven studied organs (heart, liver, spleen, lung, kidney, muscle subcutaneous fat) cattle. To investigate how methylation regulates imprinting cattle, allele-specific patterns...
A traditional Chinese medicine cantharidin which was previously found to be effective on colorectal cancer cells translated into nanoparticles for drug delivery reduce its side effects and enhance efficacy.
Lipids are essential for cellular and organismal life.These make up a significant portion of cell membranes, act as energy reserves also signal molecules.In both humans more distant species like chickens, the liver adipose tissue serve primary organs synthesis storage.It is now well accepted that Long noncoding RNAs (lncRNAs) contribute to many different types biological processes, including lipid metabolism.The key elements influencing poultry slaughter performance meat quality distribution...