A5101963123- Rough Sets and Fuzzy Logic
- Data Mining Algorithms and Applications
- Alzheimer's disease research and treatments
- Text and Document Classification Technologies
- Nanoplatforms for cancer theranostics
- Phagocytosis and Immune Regulation
- Insect and Arachnid Ecology and Behavior
- Immunotherapy and Immune Responses
- Cancer, Hypoxia, and Metabolism
- Neuroinflammation and Neurodegeneration Mechanisms
- Geoscience and Mining Technology
- RNA Interference and Gene Delivery
- Hepatocellular Carcinoma Treatment and Prognosis
- Insect Utilization and Effects
- Barrier Structure and Function Studies
- Energy Load and Power Forecasting
- Smart Grid Energy Management
- Inflammatory Biomarkers in Disease Prognosis
- Extracellular vesicles in disease
- GDF15 and Related Biomarkers
- Inflammatory mediators and NSAID effects
- Neurobiology and Insect Physiology Research
- Nanoparticle-Based Drug Delivery
- Multi-Criteria Decision Making
- Imbalanced Data Classification Techniques
Fudan University
2019-2025
Chongqing University of Posts and Telecommunications
2016-2025
Jilin Academy of Traditional Chinese Medicine
2025
South China Normal University
2022-2025
Shaanxi Provincial Hospital of Traditional Chinese Medicine
2024
Shanxi Province Hospital of Traditional Chinese Medicine
2024
Sinopec (China)
2023
University College Dublin
2023
Anhui University
2023
Fuzhou University
2016-2022
Engineered exosomes have become popular drug delivery carriers for cancer treatment. Systemic injection of organotropic exosome carrier leads to efficient targeting and efficacious anti-cancer outcome.
Treatment multiple tumors by immune therapy can be achieved mobilizing both innate and adaptive immunity. The programmed death ligand 1 (PD-L1; or CD274, B7-H1) is a critical "don't find me" signal to the system. Equally CD47 eat system regulator of response.Both PD-L1 are overexpressed on surface cancer cells enable escape immune-surveillance. We designed EpCAM (epithelial cell adhesion molecule)-targeted cationic liposome (LPP-P4-Ep) containing si-CD47 si-PD-L1 could target high-EpCAM...
Mitochondrial dysfunction in neurons has recently become a promising therapeutic target for Alzheimer’s disease (AD). Regulation of dysfunctional mitochondria through multiple pathways rather than antioxidation monotherapy indicates synergistic effects. Therefore, we developed multifunctional hybrid peptide HNSS composed antioxidant SS31 and neuroprotective S14G-Humanin. However, suitable delivery systems with excellent loading capacity effective at-site are still absent. Herein, the...
Abstract Carcinoma metastasis is triggered by a subpopulation of circulating tumor cells (CTCs). And single immune checkpoint therapy not good enough to inhibit CTC-induced metastasis. Here, we demonstrate that simultaneously blocking CD274 (programmed death ligand 1, PD-L1 or B7-H1) and CD47 checkpoints which were respectively signal “don’t find me” eat on CTCs corresponding antibodies could enhance the inhibition growth than antibody alone. In vitro flow cytometry data proved overexpressed...
Multi-scale decision system (MDS) is an effective tool to describe hierarchical data in machine learning. Optimal scale combination (OSC) selection and attribute reduction are two key issues related knowledge discovery MDSs. However, searching for all OSCs may result a combinatorial explosion, the existing approaches typically incur excessive time consumption. In this study, considered as optimization problem with space search space. Accordingly, sequential three-way model of established...
Granular computing, a new paradigm for solving large-scale and complex problems, has made significant progresses in knowledge discovery. ball computing (GBC) is novel granular method, which can rapidly generate scalable robust information granules, that is, balls. However, comprehensive index measuring the performance of does not exist. Furthermore, GBC lacks mechanism to deal with dynamic decision systems. Therefore, this study, quality first formulated. Next, index, rough sets model (GBRS)...
Pericyte dysfunction severely undermines cerebrovascular integrity and exacerbates neurodegeneration in Alzheimer's disease (AD). However, pericyte-targeted therapy is a yet-untapped frontier for AD. Inspired by the elevation of vascular cell adhesion molecule-1 (VCAM-1) reactive oxygen species (ROS) levels pericyte lesions, we fabricated multifunctional nanoprodrug conjugating hybrid peptide VLC, fusion VCAM-1 high-affinity VHS neuroprotective apolipoprotein mimetic COG1410, to curcumin...
Sorafenib is approved as a standard therapy for advanced hepatocellular carcinoma (HCC), but its clinical application limited due to moderate therapeutic efficacy and high incidence of acquired resistance resulted from elevated levels SDF-1/CXCR4 axis induced by prolonged sorafenib treatment. We previously demonstrated metapristone (RU486 metabolite) cancer metastatic chemopreventive agent targeting axis. Therefore, we hypothesized that combining with could synergistically suppress cell...
This paper presents a strong data-mining method based on rough set, which can simultaneously realize feature selection, classification, and knowledge representation. Although popular for has good interpretability, it is not sufficiently efficient accurate to deal with large-scale datasets high dimensions, prevents from being immediately applied real-world scenarios. To address the efficiency issue of we discover stability local redundancy (SLR) attributes propose theorem prove rigorously....
Pancreatic ductal adenocarcinoma (PDAC) poses significant therapeutic challenges due to excessive hyaluronic acid (HA) accumulation, which impedes drug delivery. Here, we present a targeted approach reduce HA production by specifically silencing glutamine-fructose-6-phosphate aminotransferase 1 (GFAT1), key enzyme of the hexosamine biosynthesis pathway (HBP) in pancreatic cancer cells. An engineered liposomal system for siGFAT1 delivery, PMLip@siGFAT1, characterized macrophage membrane...
The silkworm Bombyx mori is a fully domesticated insect and has lost its flight capability during domestication. However, it does not show obvious degradation of wing, rendering the mechanism flightlessness elusive. In this study, we demonstrated that B. showed insufficient wing disc developmental properties, weaker adult wings loosely arranged muscles with smaller cell size relatively flapping frequency, compared mandarina . Consistently, switch transcriptomic landscape from larval to pupal...
Compromised autophagy and defective lysosomal clearance significantly contribute to impaired neuronal proteostasis, which represents a hallmark of Alzheimer's disease (AD) other age-related neurodegenerative disorders. Growing evidence has implicated that modulating autophagic flux, instead inducing autophagosome formation alone, would be more reliable rescue proteostasis. Concurrently, selectively enhancing drug concentrations in the leision areas, whole brain, will maximize therapeutic...
Abstract Background In insects, an interplay between the activities of distinct hormones, such as juvenile hormone (JH) and 20-hydroxyecdysone (20E), regulates progression through numerous life history hallmarks. As a crucial endocrine factor, JH is mainly synthesized in corpora allata (CA) to regulate multiple physiological developmental processes, including molting, metamorphosis, reproduction. During last century, significant progress has been achieved elucidating signal transduction...
Slickwater fracturing fluids are widely used in the development of unconventional oil and gas resources due to advantages low cost, formation damage high drag reduction performance. However, their performance is severely affected at temperatures. Drag reducing agent key determine slickwater. In this work, order further improve temperature resistance slickwater, a temperature-resistant polymeric (PDRA) was synthesized as basis for preparing The slickwater system prepared with compositions 0.2...