A5102728538- Origins and Evolution of Life
- Topic Modeling
- RNA and protein synthesis mechanisms
- Natural Language Processing Techniques
- Bacterial Genetics and Biotechnology
- Structural Behavior of Reinforced Concrete
- Photosynthetic Processes and Mechanisms
- Photoreceptor and optogenetics research
- Innovative concrete reinforcement materials
- Acupuncture Treatment Research Studies
- Text Readability and Simplification
- Recycled Aggregate Concrete Performance
- Advanced Text Analysis Techniques
- Insect and Arachnid Ecology and Behavior
- Protein Structure and Dynamics
- Structural Load-Bearing Analysis
- Calcium Carbonate Crystallization and Inhibition
- Evolution and Genetic Dynamics
- Speech and dialogue systems
- Cerebrospinal fluid and hydrocephalus
- Plant and Biological Electrophysiology Studies
- Insect Utilization and Effects
- Analytical Chemistry and Sensors
- Sentiment Analysis and Opinion Mining
- Advanced Data Storage Technologies
Wuhan University
2015-2025
Chinese Center For Disease Control and Prevention
2023
South China Normal University
2022-2023
Center for Disease Control
2022
Xi'an Jiaotong University
2018
Zhejiang University
2015
Second Military Medical University
2011
Wuhan College
2003
Yiming Cui, Ting Liu, Wanxiang Che, Li Xiao, Zhipeng Chen, Wentao Ma, Shijin Wang, Guoping Hu. Proceedings of the 2019 Conference on Empirical Methods in Natural Language Processing and 9th International Joint (EMNLP-IJCNLP). 2019.
Most pre-trained language models (PLMs) construct word representations at subword level with Byte-Pair Encoding (BPE) or its variations, by which OOV (out-of-vocab) words are almost avoidable. However, those methods split a into units and make the representation incomplete fragile.In this paper, we propose character-aware model named CharBERT improving on previous (such as BERT, RoBERTa) to tackle these problems. We first contextual embedding for each token from sequential character...
How homochirality concerning biopolymers (DNA/RNA/proteins) could have originally occurred (i.e., arisen from a non-life chemical world, which tended to be chirality-symmetric) is long-standing scientific puzzle. For many years, people focused on exploring plausible physic-chemical mechanisms that may led prebiotic environments biased one chiral type of monomers (e.g., D-nucleotides against L-nucleotides; L-amino-acids D-amino-acids)–which should then assembled into corresponding polymers...
Abstract Modern cell membranes are primarily composed of phospholipids, while primitive in the beginning life believed to have formed from simpler lipids (such as fatty acids) synthesized prebiotic environment. An attractive experimental study suggested that corresponding “membrane-takeover” (as an evolutionary process) is likely occurred very early (e.g. RNA world) due some simple physical effects, and might subsequently triggered other processes. Here, via computer modeling on a system...
Abstract Background In insects, an interplay between the activities of distinct hormones, such as juvenile hormone (JH) and 20-hydroxyecdysone (20E), regulates progression through numerous life history hallmarks. As a crucial endocrine factor, JH is mainly synthesized in corpora allata (CA) to regulate multiple physiological developmental processes, including molting, metamorphosis, reproduction. During last century, significant progress has been achieved elucidating signal transduction...
Though the "RNA world" hypothesis has gained a central role in ideas concerning origin of life, scenario its emergence remains uncertain. It been speculated that first scene may have template-dependent RNA synthetase ribozyme, which catalyzed own replication: thus, replicase." However, speculation uncertain, primarily because large sequence length requirement such replicase and lack convincing mechanism to ensure self-favoring features. Instead, we propose nucleotide ribozyme as an...
Machine Reading Comprehension (MRC) with multiple-choice questions requires the machine to read given passage and select correct answer among several candidates. In this paper, we propose a novel approach called Convolutional Spatial Attention (CSA) model which can better handle MRC questions. The proposed could fully extract mutual information passage, question, candidates, form enriched representations. Furthermore, merge various attention results, use convolutional operation dynamically...
Despite the meridian system being an important concept in Traditional Chinese Medicine (TCM), modern biology and Western medical systems have failed to find anatomic substrate. Since 1960s, a variety of phenomena along meridians been reported, among which quite few suggest that there is fluid pathway (but not blood vessels or lymphatics). On other hand, perivascular space (PVS) has demonstrated be body addition lymphatics some mammalian tissues, such as brain, thymus, lung.The present study...
It is very likely that life began with some RNA (or RNA-like) molecules, self-replicating by base-pairing and exhibiting enzyme-like functions favored the self-replication. Different functional molecules may have emerged favoring their own self-replication at different aspects. Then, a direct route towards complexity/efficiency been through coexistence/cooperation of these molecules. However, likelihood this remains quite unclear, especially because would be competing for limited common...
It is now popularly accepted that an "RNA world" existed in early evolution. During division of RNA-based protocells, random distribution individual genes (simultaneously as ribozymes) between offspring might have resulted gene loss, especially when the number types increased. Therefore, emergence a chromosome carrying linked was critical for prosperity RNA world. However, there were quite few immediate difficulties this event to occur. For example, would be much longer than genes, and thus...
Insects have evolved numerous adaptations and colonized diverse terrestrial environments. Several polyneopterans, including dictyopterans (cockroaches mantids) locusts, developed oothecae, but little is known about the molecular mechanism, physiological function, evolutionary significance of ootheca formation. Here, we demonstrate that cockroach asymmetric colleterial glands produce vitellogenins, proline-rich protein, glycine-rich protein as major structural proteins (OSPs) undergo...
It is now believed that in the origin of life, proteins should have been "invented" an RNA world. However, due to complexity a possible RNA-based proto-translation system, this evolving process seems quite complicated and associated scenario remains very blurry. Considering can bind amino acids with specificity, it has reasonably supposed initial peptides might synthesized on "RNA templates" containing multiple acid binding sites. This "Direct Template (DRT)" mechanism attractive because be...
Owing to the continuous efforts by Chinese NLP community, more and machine reading comprehension datasets become available. To add diversity in this area, paper, we propose a new task called Sentence Cloze-style Machine Reading Comprehension (SC-MRC). The proposed aims fill right candidate sentence into passage that has several blanks. We built dataset CMRC 2019 evaluate difficulty of SC-MRC task. Moreover, difficulties, also made fake candidates are similar correct ones, which requires...
The "RNA world" hypothesis has offered a framework for both experimental and theoretical work in the field of origin life. An important concern about is how RNA world could originate. It long been speculated that template-dependent synthetase ribozyme, which catalyzed its own replication (thus, an replicase"), should have emerged first. However, searches such replicase so far unsuccessful. This primarily because large sequence length candidate ribozymes, mainly polymerase-like way. Here, we...