A5015549444- Toxoplasma gondii Research Studies
- Heme Oxygenase-1 and Carbon Monoxide
- Extracellular vesicles in disease
- Periodontal Regeneration and Treatments
- Cytomegalovirus and herpesvirus research
- Mesenchymal stem cell research
- Autophagy in Disease and Therapy
- Metal-Organic Frameworks: Synthesis and Applications
- Catalytic Processes in Materials Science
- Inflammasome and immune disorders
- Pluripotent Stem Cells Research
- NF-κB Signaling Pathways
- Bone Tissue Engineering Materials
- Osteoarthritis Treatment and Mechanisms
- Bone Metabolism and Diseases
- Geotechnical and Geomechanical Engineering
- Rock Mechanics and Modeling
- Knee injuries and reconstruction techniques
- Reproductive System and Pregnancy
- Herpesvirus Infections and Treatments
- Ocular Diseases and Behçet’s Syndrome
- Hydrogen's biological and therapeutic effects
- Cancer-related gene regulation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Membrane Separation and Gas Transport
Guangdong Medical College
2016-2025
Liaoning University
2022-2024
Lu'an First People's Hospital
2024
Anhui University of Science and Technology
2020-2023
Anhui Medical University
2023
Beijing Haidian Hospital
2022
Shanghai Cell Therapy Research Institute
2022
Shanghai University
2019
Sun Yat-sen University
2015-2018
Case Western Reserve University
2018
Abstract Introduction Osteoarthritis (OA) is an inflammatory disease of the joints that causes progressive disability in elderly. Reactive oxygen species (ROS) play important role OA development; they may activate NLRP3 inflammasome, thereby inducing secretion proinflammatory IL-1β and IL-18, leading to aggravation downstream response. Nrf2 a key transcription factor regulates expression antioxidant enzymes protect against oxidative stress tissue damage. We aimed explore underlying mechanism...
Toxoplasma gondii can invade and replicate in all nucleated cells a wide range of host species, infection induces IL-1β production. plays central roles the stimulation innate immune system inflammation. However, little is known responses human fetal small intestinal epithelial (FHs 74 Int cells) after T. infection. FHs were infected with GFP-RH strain. Then, production its mechanisms action evaluated using ELISA, MTT cell viability assays, Western blotting, immunofluorescence, quantitative...
Hard carbon materials are considered as the most promising anode for sodium-ion batteries (SIBs). However, high cost and poor rate performance hinder their application in SIBs. Moreover, controversial mechanism of Na-ion storage restricts improvement hard anodes. Herein, micro-nano tubes (HCMNTs) from low-cost biomass kapok fibers prepared a Benefitting structure, which offers low surface area short Na+ diffusion path, 1400HCMNT possesses good initial Coulombic efficiency 80%, reversible...
Abstract: Apoptosis of osteoblasts triggered by high-dose glucocorticoids (GCs) has been identified as a major cause osteoporosis. However, the underlying molecular mechanisms accounting for this action remain elusive, which impeded prevention and cure side effect. Sulforaphane (SFP) is naturally occurring isothiocyanate that huge health benefits humans. In study, using osteoblastic MC3T3-E1 cells model, we demonstrate protective effects SFP against dexamethasone (Dex)-induced apoptosis...
Abstract Three‐dimensional scaffolds like hydrogels can be employed as cell carriers for in vitro or vivo colonization and have become a major research topic to replace damaged tissue. In the current study, novel composite hydrogel composed of sodium alginate (SA) platelet‐rich‐plasma (PRP) varying blending ratios, cross‐linked with calcium ions, released from carbonate‐D‐Glucono‐d‐lactone (CaCO 3 ‐GDL) was successfully prepared. It found that addition PRP changed largely physical properties...
Al−MCM-41 adsorbents with different SiO2/Al2O3 molar ratios (100, 50, and 30) were synthesized used for desulfurization of a commercial diesel fuel (sulfur content = 1786 ppmw) at 373 K. The characterized by means X-ray diffraction, N2 adsorption isotherm, Fourier transform infrared, high-resolution transmission electron microscopy techniques. capacity sulfur-containing compounds was found to follow the order: Al−MCM-41(50) > Al−MCM-41(30) Al−MCM-41(100) (the number in parentheses is ratio...
Toxoplasma gondii is distributed worldwide and infects most species of warm-blooded animals, including humans. The heavy incidence severe or lethal damage caused by T. infection clearly indicates the need for development a vaccine. To evaluate protective efficacy multiantigenic DNA vaccine expressing GRA7 ROP1 with without plasmid encoding murine interleukin-12 (pIL12), we constructed vaccines using eukaryotic plasmids pGRA7, pROP1, pGRA7-ROP1. Mice immunized pGRA7-ROP1 showed significantly...
Interleukin (IL)-23 and IL-12 are closely related in structure, these cytokines regulate both innate adaptive immunity. However, the precise signaling networks that production of each Toxoplasma gondii-infected THP-1 monocytic cells, particularly PI3K/AKT MAPK pathways, remain unknown. In present study, T. gondii infection upregulated expression IL-23 increased with parasite dose. secretion was strongly inhibited by TLR2 monoclonal antibody (mAb) treatment a dose-dependent manner siRNA...
We evaluated the efficacy of platelet‐rich plasma (PRP) in combination with allogeneic bone marrow mesenchymal stem cells (BMSCs) for treatment osteoporotic defects an ovariectomized rat model. By day 42 after injury, vivo microcomputed tomography (micro‐CT) imaging revealed that control rats and treated PRP BMSCs were completely repaired, whereas those or alone exhibited slower healing. Histological data consistent these results. also assessed changes to trabeculae proximal tibial growth...
Herein, three In(III)-based metal–organic frameworks (In-MOFs) with different degrees of interpenetration (DOI), namely In-MOF-1, In-MOF-2, and In-MOF-3, constructed by In3+ Y-shaped ligands 4,4′,4″-s-triazine-2,4,6-triyltribenzoate (H3TATB), are successfully synthesized through the ionothermal/solvothermal method. Subsequently, novel In-MOFs, including noninterpenetration polycatenation, 2-fold interpenetrated, 4-fold interpenetrated structure, employed as platform for systematically...
Toxoplasma gondii is an obligate intracellular parasite that stimulates production of high levels proinflammatory cytokines, which are important for innate immunity. NLRs, i.e., nucleotide-binding oligomerization domain (NOD)-like receptors, play a crucial role as immune sensors and form multiprotein complexes called inflammasomes, mediate caspase-1-dependent processing pro-IL-1β. To elucidate the inflammasome components in T. gondii-infected THP-1 macrophages, we examined...
External and internal stimuli easily affect the retina. Studies have shown that cells infected with Toxoplasma gondii are resistant to multiple inducers of apoptosis. Nanoparticles (NPs) been widely used in biomedical fields; however, little is known about cytotoxicity caused by NPs retina modulators inhibit nanotoxicity.ARPE-19 from human retinal pigment epithelium were treated silver nanoparticles (AgNPs) alone or combination T. gondii. Then, cellular toxicity, apoptosis, cell cycle...
Autophagy and apoptosis are critical for controlling Toxoplasma gondii (T. gondii) infection. T. infection during pregnancy can damage the fetus cause birth defects; however, molecular mechanisms of this process poorly understood. This study aims to determine activities autophagy as well their regulatory by using human umbilical cord mesenchymal stem cells (hUC-MSCs) a model congenital diseases. LC3B, hallmark protein was incrementally upregulated with duration, whereas p62 downregulated in...
Deep high static loading roadway is extremely prone to rock burst under dynamic load disturbance. The “force-energy criterion” for the failure of surrounding in such deep roadways and “energy was established by considering stress energy evolution characteristics this circumstance. Under engineering background main No.1 mining area Gaojiapu Coal Mine Binchang Mining Area, Shaanxi Province, China, partial field distortion spatial-temporal laws disturbance were simulated analyzed using a...