A5100773170- Cutaneous Melanoma Detection and Management
- RNA regulation and disease
- CAR-T cell therapy research
- PI3K/AKT/mTOR signaling in cancer
- Hydrogen's biological and therapeutic effects
- Antioxidants, Aging, Portulaca oleracea
- Click Chemistry and Applications
- Protein Degradation and Inhibitors
- Vibrio bacteria research studies
- Gynecological conditions and treatments
- Biomedical Text Mining and Ontologies
- Semantic Web and Ontologies
- Acupuncture Treatment Research Studies
- Toxoplasma gondii Research Studies
- Renal and related cancers
- Immune Response and Inflammation
- Control and Dynamics of Mobile Robots
- Sirtuins and Resveratrol in Medicine
- Birth, Development, and Health
- Uterine Myomas and Treatments
- Reproductive Biology and Fertility
- Nonlinear Waves and Solitons
- Effects and risks of endocrine disrupting chemicals
- Antibiotic Resistance in Bacteria
- NF-κB Signaling Pathways
Huazhong University of Science and Technology
2024-2025
Tongji Hospital
2024-2025
Guangdong Medical College
2022-2025
China Three Gorges University
2022-2024
National Institutes of Health
2015
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2015
J. Craig Venter Institute
2009
Abstract Colorectal cancer stem cells (CCSCs) play a critical role in mediating chemoresistance. Lactylation is post-translational modification induced by lactate that regulates gene expression. However, whether lactylation affects the chemoresistance of CCSCs remains unknown. Here, we demonstrate histone enhances CCSC both vitro and vivo. Furthermore, our findings showed p300 catalyzes H4 at K12, whereas HDAC1 facilitates its delactylation CCSCs. Notably, H4K12 (H4K12la) upregulates GCLC...
Purpose With the rapid advancement of time-lapse culture and artificial intelligence (AI) technologies for embryo screening, pregnancy rates in assisted reproductive technology (ART) have significantly improved. However, clinical fresh cycles remain dependent on number type embryos transferred. The selection with highest implantation potential is critical embryologists influences transfer strategies fertility centers. superiority AI over traditional morphological scoring ranking...
Background: Longitudinal or time-dependent activity data are useful to characterize the circadian patterns and identify physical differences among multiple samples. Statistical methods designed analyze sample desired, related software is needed perform analysis.Methods: This paper introduces a functional analysis (fda) approach of variance (fANOVA) for longitudinal count investigate association covariates such as weight body mass index (BMI) on activity. For age group adolescent school...
<title>Abstract</title> Radiotherapy and chemotherapy compromise individuals’ immunity clinically, resulting in increased opportunistic infections. In this study, the cyclophosphamide-induced immunocompromised C57BL/6J mouse with Klebsiella infection was hired to analyze effect of active components Acanthopanax senticosus on anti-infection for individuals. As a result, polysaccharide (ASPS) selected best effect. For mouse, ASPS its indices thymus spleen, reducing bacteria load lung...
<title>Abstract</title> <bold>Objective</bold> This study aims to evaluate the efficacy of thumbtack needle (TN) therapy at ST36 acupoint in reducing postoperative ileus (POI) duration following elective abdominal surgery. <bold>Background</bold> Postoperative is a frequent complication after surgeries, leading delayed gastrointestinal recovery. TN therapy, non-invasive form acupuncture, has shown promise promoting function However, its specific impact on POI, particularly acupoint, requires...
*Abstract*Phenotypic data are routinely used to elucidate gene and protein function in most organisms amenable experimental manipulation. However, although phenotype ontologies exist for many eukaryotic model organisms, no standardized system exists the capture of phenotypic information bacteria. We propose build an Ontology Microbial Phenotypes use it annotate prokaryotic organism Escherichia coli.*Introduction*Phenotypes observable characteristics that result from combination a particular...
The modeling of a two wheeled cart models based on the quasi-canonization method is studied in this paper . For model, set suitable quasi-coordinates and quasi-momentums are defined according to geometric characteristics its configuration space, so that motion differential equations model written form Hamilton.. s canonical equation. In way, nonholonomic constraining force disappears from model. And number also reduced due constraints cart. Moreover, means has special symplectic structure...
<p>Supplementary Figure Legend</p>
<p>Supplementary Figures S1-9 and Tables S1-3. Supplementary Figure S1 - Effects of knockdown NUAK2 on melanoma cells specificity the p-AKT antibody. S2 Immunohistochemical analyses p-Akt expression in clinical specimens. S3 Kaplan-Meier curves for overall survival Acral Non-CSD patients. S4 Knockdown induces apoptosis SM2-1 cells. S5 Immunohistochemistry showing p21 following inhibition PI3K pathway by LY294002. S6 Schematic diagram regulation cell cycle machinery pathways. S7 CDK2...
<p>Supplementary Figure Legend</p>
<p>Supplementary Figures S1-9 and Tables S1-3. Supplementary Figure S1 - Effects of knockdown NUAK2 on melanoma cells specificity the p-AKT antibody. S2 Immunohistochemical analyses p-Akt expression in clinical specimens. S3 Kaplan-Meier curves for overall survival Acral Non-CSD patients. S4 Knockdown induces apoptosis SM2-1 cells. S5 Immunohistochemistry showing p21 following inhibition PI3K pathway by LY294002. S6 Schematic diagram regulation cell cycle machinery pathways. S7 CDK2...
<div>Abstract<p>The AMPK-related kinase NUAK2 has been implicated in melanoma growth and survival outcomes, but its therapeutic utility yet to be confirmed. In this study, we show how genetic amplification <i>PTEN</i>-deficient melanomas may rationalize the use of CDK2 inhibitors as a strategy. Analysis array-CGH data revealed that <i>PTEN</i> deficiency is coupled tightly with genomic encompassing <i>NUAK2</i> locus, finding strengthened by...
<div>Abstract<p>The AMPK-related kinase NUAK2 has been implicated in melanoma growth and survival outcomes, but its therapeutic utility yet to be confirmed. In this study, we show how genetic amplification <i>PTEN</i>-deficient melanomas may rationalize the use of CDK2 inhibitors as a strategy. Analysis array-CGH data revealed that <i>PTEN</i> deficiency is coupled tightly with genomic encompassing <i>NUAK2</i> locus, finding strengthened by...