A5013409053- Genetic Associations and Epidemiology
- Genetic Mapping and Diversity in Plants and Animals
- Genetic and phenotypic traits in livestock
- Neonatal Respiratory Health Research
- Bioinformatics and Genomic Networks
- Genomic variations and chromosomal abnormalities
- Folate and B Vitamins Research
- Gene expression and cancer classification
- Congenital heart defects research
- Neuroscience of respiration and sleep
- advanced mathematical theories
- Prenatal Screening and Diagnostics
- Congenital Diaphragmatic Hernia Studies
- Congenital Heart Disease Studies
- Respiratory Support and Mechanisms
- Genetic Syndromes and Imprinting
- Mathematical and Theoretical Analysis
- Obesity, Physical Activity, Diet
- Pregnancy and preeclampsia studies
- Iron Metabolism and Disorders
- Stability and Controllability of Differential Equations
- Nonlinear Differential Equations Analysis
- Epigenetics and DNA Methylation
- Chronic Lymphocytic Leukemia Research
- Stochastic processes and financial applications
Taiyuan University of Science and Technology
2025
National Institutes of Health
2013-2024
Georgetown University
2017-2024
Georgetown University Medical Center
2017-2024
National Human Genome Research Institute
2018-2024
Kunming Medical University
2018
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2012-2017
John Wiley & Sons (United States)
2017
Haukeland University Hospital
2014
University of Bergen
2014
ABSTRACT Functional linear models are developed in this paper for testing associations between quantitative traits and genetic variants, which can be rare variants or common the combination of two. By treating multiple an individual a human population as realization stochastic process, genome chromosome region is continuum sequence data rather than discrete observations. The viewed function that contains both linkage disequilibrium (LD) information markers. using techniques functional...
For complex diseases, the relationship between genotypes, environment factors, and phenotype is usually nonlinear. Our understanding of genetic architecture diseases has considerably increased over last years. However, both conceptually methodologically, detecting gene-gene gene-environment interactions remains a challenge, despite existence number efficient methods. One method that offers great promises but not yet been widely applied to genomic data entropy-based approach information...
ABSTRACT In genetics, pleiotropy describes the genetic effect of a single gene on multiple phenotypic traits. A common approach is to analyze traits separately using univariate analyses and combine test results through comparisons. This may lead low power. Multivariate functional linear models are developed connect variant data quantitative adjusting for covariates unified analysis. Three types approximate F ‐distribution tests based Pillai–Bartlett trace, Hotelling–Lawley Wilks's Lambda...
In recent years, global climate change and human activities have intensified the frequency severity of floods. Based on big data flood probability, combined with index monsoon intensity, river management, deforestation, urbanization change, this paper studies from perspective probability prediction. Firstly, selects indicators collects corresponding data, processes data. Then, importance characteristics is evaluated by random forest algorithm. Secondly, number final determined kernel...
Background Network intrusion detection is a critical component of maintaining network security, especially as cyber threats become increasingly sophisticated. While deep learning-based algorithms have shown promise, they often struggle with high-dimensional datasets containing outliers, anomalies, or rare events. This study addresses these challenges by proposing novel approach that combines the Improved Gravitational Search Algorithm (IGSA) Soft Actor-Critic (SAC) reinforcement learning...
BPD_28D (O 2 dependency at 28 days of life) and BPD_36W 36 wks post‐menstrual age) are diseases prematurely born infants exposed to mechanical ventilation and/or oxygen supplementation. In order determine whether genetic variants surfactant proteins (SPs‐A, B, C, D) SP‐B‐linked microsatellite markers risk factors in BPD, we performed a family based association study using Greek group 71 neonates (<30 gestational from 60 families with, 52 19 BPD_36W, affected infants. Genotyping was newly...
Over the past several years, genome-wide association studies (GWAS) have succeeded in identifying hundreds of genetic markers associated with common diseases. However, most these confer relatively small increments risk and explain only a proportion familial clustering. To identify obstacles to future progress epidemiology research provide recommendations NIH for overcoming barriers, National Cancer Institute sponsored workshop entitled "Next Generation Analytic Tools Large-Scale Genetic...
Abstract Background : The etiology of respiratory distress syndrome (RDS) is multifactorial and/or multigenic. Surfactant protein A (SP‐A) SP‐B genetic variants have been identified as risk or protection factors for RDS. Methods We genotyped subjects with and without RDS the intron 4 size (invariant (inv), deletion (del), insertion (ins) four (–18 (A/C), 1013 1580 (C/T), 9306 (A/G)) single nucleotide polymorphisms (SNP), to study case–control associations in black white subjects. also...
A key cause of respiratory distress syndrome (RDS) in the prematurely born infant is deficiency pulmonary surfactant, a lipoprotein complex. Both low levels surfactant protein (SP‐A) and SP‐A alleles have been associated with RDS. Using candidate gene approach, we performed family‐based linkage studies to discern RDS identify susceptibility or protective alleles. Moreover, case–control whites blacks detect association between Transmission disequilibrium test (TDT) analysis revealed that...
<h3>Importance</h3> Infantile hypertrophic pyloric stenosis (IHPS) is a serious condition in which hypertrophy of the sphincter muscle layer leads to gastric outlet obstruction. shows strong familial aggregation and heritability, but knowledge about specific genetic risk variants limited. <h3>Objectives</h3> To search genome comprehensively for associations with IHPS validate findings 3 independent sample sets. <h3>Design, Setting, Participants</h3> During stage 1, we used reference data...
The cause of posterior urethral valves (PUV) is unknown, but genetic factors are suspected given their familial occurrence. We examined cases isolated PUV to identify novel copy number variants (CNVs). identified 56 from all live‐births in New York State (1998–2005). Samples were genotyped using Illumina HumanOmni2.5 microarrays. Autosomal and sex‐linked CNVs PennCNV cnvPartition software. prioritized for follow‐up if they absent in‐house controls, contained ≥10 consecutive probes, ≥20 Kb...
Abstract Women who develop gestational diabetes mellitus or impaired glucose tolerance during pregnancy are at substantially increased risk for type 2 and comorbidities after pregnancy. Little is known about the role of genetic factors their interactions with environmental in determining transition from to overt mellitus. These critical data gaps served as impetus this Diabetes & Women's Health study overall goal investigating amenable clinical public health interventions relation To...
By using functional data analysis techniques, we developed generalized linear models for testing association between a dichotomous trait and multiple genetic variants in region while adjusting covariates. Both fixed mixed effect are compared. Extensive simulations show that Rao's efficient score tests of the very conservative since they generate lower type I errors than nominal levels, global accurate errors. Furthermore, found test statistics have higher power sequence kernel (SKAT) its...
Abstract Meta-analysis of genetic data must account for differences among studies including study designs, markers genotyped, and covariates. The effects variants may differ from population to population, i.e., heterogeneity. Thus, meta-analysis combining multiple is difficult. Novel statistical methods are needed. In this article, functional linear models developed meta-analyses that connect quantitative traits, adjusting can be used analyze rare variants, common or a combination the two....
Abstract Aims: Polymorphisms of genes are transmitted together in haplotypes, which can be used the study development complex diseases such as respiratory distress syndrome (RDS). The surfactant proteins (SPs) play important roles lung function, and genetic variants these have been linked with diseases, including RDS. To determine whether haplotypes SP‐A SP‐D disproportionately from parents to offspring RDS, we hypothesized that previously unstudied SP associated Methods: DNA was collected...