A5078901632- Statistical Methods in Clinical Trials
- Statistical Methods and Inference
- Statistical Methods and Bayesian Inference
- Gestational Diabetes Research and Management
- Obesity, Physical Activity, Diet
- Birth, Development, and Health
- Optimal Experimental Design Methods
- Advanced Statistical Methods and Models
- Nutritional Studies and Diet
- Diabetes Management and Research
- Genetic Associations and Epidemiology
- Eating Disorders and Behaviors
- Advanced Statistical Process Monitoring
- Genetic and phenotypic traits in livestock
- SARS-CoV-2 detection and testing
- Epigenetics and DNA Methylation
- Child and Adolescent Psychosocial and Emotional Development
- Gene expression and cancer classification
- Posttraumatic Stress Disorder Research
- Advanced Causal Inference Techniques
- Pregnancy and preeclampsia studies
- Receptor Mechanisms and Signaling
- Health Systems, Economic Evaluations, Quality of Life
- Bariatric Surgery and Outcomes
- Nicotinic Acetylcholine Receptors Study
National Institutes of Health
2016-2025
Beijing Normal University
2020-2024
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2015-2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2017-2024
Chongqing Medical University
2017-2024
Royal Prince Alfred Hospital
2024
Sydney Local Health District
2024
Eastern Virginia Medical School
2023
National University of Singapore
2023
University at Buffalo, State University of New York
2014-2020
Costs can hamper the evaluation of effectiveness new biomarkers. Analysis smaller numbers pooled specimens has been shown to be a useful cost-cutting technique. The Youden index (J), function sensitivity (q) and specificity (p), is commonly used measure overall diagnostic effectiveness. More importantly, J maximum vertical distance or difference between ROC curve diagonal chance line; it occurs at cut-point that optimizes biomarker's differentiating ability when equal weight given...
Biomarker use in exposure assessment is increasingly common, and consideration of related issues growing importance. Exposure quantification may be compromised when measurement subject to a lower threshold. Statistical modeling such data requires decision regarding the handling readings. Various authors have considered this problem. In context linear regression analysis, Richardson Ciampi (Am J Epidemiol 2003;157:355–63) proposed replacement below threshold by constant equal expectation for...
The circadian clock synchronizes the activity level of an organism to light-dark cycle environment. Energy intake, as well energy metabolism, also has a diurnal rhythm. Although role genes in sleep-wake is characterized, their generation metabolic rhythms poorly understood. Here, we use mice deficient protein mPer2 study how regulates two critical rhythms: glucocorticoid and food intake rhythms. Our findings indicate that mPer2−/− do not have rhythm even though corticosterone response...
Inefficient mitochondrial electron transport chain (ETC) function has been implicated in the vicious cycle of reactive oxygen species (ROS) production that may predispose an individual to late onset diseases, such as diabetes, hypertension, and cancer. Mitochondrial DNA (mtDNA) variations affect efficiency ETC ROS production, thus contributing cancer risk. To test this hypothesis, we genotyped 69 mtDNA 156 unrelated European-American females with familial breast 260 age-matched female...
Women with a history of gestational diabetes mellitus (GDM) are at substantially increased risk type 2 (T2DM). The identification important modifiable factors could help prevent T2DM in this high-risk population.
Abstract Defective lysosomal acidification contributes to virtually all storage disorders (LSDs) and common neurodegenerative diseases like Alzheimer’s Parkinson’s. Despite its fundamental importance, the mechanism(s) underlying this defect remains unclear. The v-ATPase, a multisubunit protein complex composed of cytosolic V1-sector membrane-anchored V0-sector, regulates acidification. Mutations in CLN1 gene, encoding PPT1, cause devastating LSD, INCL. Here we report that Cln1 −/− mice,...
Epigenetic dysregulation, which leads to the alteration of gene expression in brain, is suggested as one key pathophysiological bases ageing and neurodegeneration. Here we found that, late-stage familial Alzheimer's disease (FAD) mouse model, repressive histone H3 dimethylation at lysine 9 (H3K9me2) euchromatic methyltransferases EHMT1 EHMT2 were significantly elevated prefrontal cortex, a cognitive region affected disease. Elevated levels H3K9me2 also detected cortex post-mortem tissues...
Abstract Objectives To evaluate the individual and combined associations of five modifiable risk factors with type 2 diabetes among women a history gestational mellitus examine whether these differ by obesity genetic predisposition to diabetes. Design Prospective cohort study. Setting Nurses’ Health Study II, US. Participants 4275 mellitus, repeated measurements weight lifestyle followed up between 1991 2009. Main outcome measure Self-reported, clinically diagnosed Five were assessed,...
In this study, we analysed gene amplification, RNA expression and protein of the c-myc on archival tissue specimens high-grade human breast cancer, using fluorescent in situ hybridisation (FISH), nonradioactive immunohistochemistry. The specific question that addressed was whether c-Myc mRNA were correlated with its copy as determined by FISH. Although is one most commonly amplified oncogenes few studies have utilised approaches to directly analyse transcription tumour sections. We now...
Angiopoietin-1 (Ang1) has been shown to act as an angiogenic promoter in embryonic angiogenesis by promoting vascular branching, pericyte recruitment and endothelial survival. We have investigated the role of Ang1 tumour neovascularization under clinical conditions animal models. The expression breast cancer specimens was analysed using laser-capture microdissection reverse transcriptase-linked polymerase chain reaction (RT-PCR) on RNA isolated from samples. Despite many human cell lines,...
Studies in both human and animal species have suggested that oxidative stress may be associated with health outcomes, including the risk of infertility males females. Sex hormones been shown to antioxidant properties. The difficulty studying role females is partly due fluctuation these endogenous sex across menstrual cycle. aim this study was determine association levels reproductive hormone antioxidants, vitamin levels, cycle a prospective cohort premenopausal women. goal enroll 250...
In Brief Objective: There is now convincing evidence that usual hormone therapy for ovarian failure increases the risk breast cancer. We have previously shown androgens normally protect mammary epithelial cells from excessive estrogenic stimulation, and therefore we hypothesized addition of testosterone to might women Design: This was a retrospective, observational study followed 508 postmenopausal receiving in South Australia. Breast cancer status ascertained by mammography at initiation...
To test the effect on diabetes management outcomes of a low-intensity, clinic-integrated behavioral intervention for families youth with type 1 diabetes.Families (n = 390) obtaining care participated in 2-year randomized clinical trial designed to improve family practices. Measurement hemoglobin A1c, primary outcome, was obtained at each clinic visit and analyzed centrally. Blood glucose meter data were downloaded visit. Adherence assessed by using semistructured interview baseline,...
Diets of children with type 1 diabetes are low in fruits, vegetables, and whole grains, high foods minimal nutritional value, increasing risk for future adverse health outcomes. This 18-month randomized clinical trial tested the effect a family-based behavioral intervention integrating motivational interviewing, active learning, applied problem-solving on primary outcomes dietary intake glycemic control among youth diabetes. A parallel-group study equal randomization was conducted at an...
The lateral habenula (LHb) is a key brain region involved in the pathophysiology of depression. It activated by stimuli associated with negative experiences and encoding aversive signals. Hyperactivity LHb found both rodent models depression human patients However, little known about underlying molecular mechanisms. Here we show that neurons, p11, multifunctional protein implicated depression, significantly upregulated chronic restraint stress. Knockdown p11 expression alleviates...
Leptomeningeal disease (LMD) significantly affects the prognosis and treatment of pediatric patients with medulloblastoma or primitive neuroectodermal tumor (PNET). Examination CSF for malignant cells, detection LMD on spinal magnetic resonance imaging (MRI), both are methods routinely used to diagnose LMD. A recent study suggested 100% correlation between MRI findings in children medulloblastoma. To determine validity this hypothesis, we compared rate concurrent lumbar cytology performed at...