A5008284896- Gestational Diabetes Research and Management
- Birth, Development, and Health
- Nutritional Studies and Diet
- Pregnancy and preeclampsia studies
- Bariatric Surgery and Outcomes
- Obesity, Physical Activity, Diet
- Cardiovascular Health and Risk Factors
- Breastfeeding Practices and Influences
- Dementia and Cognitive Impairment Research
- Fatty Acid Research and Health
- Diabetes Treatment and Management
- Per- and polyfluoroalkyl substances research
- Ovarian cancer diagnosis and treatment
- Healthcare Systems and Practices
- Toxic Organic Pollutants Impact
- Nutrition and Health in Aging
- Ovarian function and disorders
- Child Nutrition and Water Access
- Diet and metabolism studies
- Fluoride Effects and Removal
- Gout, Hyperuricemia, Uric Acid
- Maternal and Perinatal Health Interventions
- Blood Pressure and Hypertension Studies
- Menstrual Health and Disorders
- Pregnancy-related medical research
National University of Singapore
2004-2025
University of Southern California
2025
Harvard University
2019-2022
Brigham and Women's Hospital
2019
Sanofi (United States)
2018-2019
Women with a history of gestational diabetes (GD) are at high risk for developing type 2 (T2D). Sleep is crucial lifestyle factor associated cardiometabolic health, yet studies on its role in the progression from GD to T2D sparse. To investigate associations sleep duration and quality levels glucose metabolism biomarkers women GD. This cohort study used data Nurses' Health Study II, an ongoing longitudinal that began 1989 initially included 116 429 female nurses health status factors updated...
Abstract Objectives To evaluate the individual and combined associations of five modifiable risk factors with type 2 diabetes among women a history gestational mellitus examine whether these differ by obesity genetic predisposition to diabetes. Design Prospective cohort study. Setting Nurses’ Health Study II, US. Participants 4275 mellitus, repeated measurements weight lifestyle followed up between 1991 2009. Main outcome measure Self-reported, clinically diagnosed Five were assessed,...
OBJECTIVE Breastfeeding duration is inversely associated with risks of cardiovascular disease (CVD) and type 2 diabetes in parous women. However, the association among women at high risk, including or gestational mellitus (GDM) unclear. RESEARCH DESIGN AND METHODS We included 15,146 from Nurses’ Health Study I II (NHS, NHS II) 4,537 a history GDM II. Participants reported breastfeeding via follow-up questionnaires. Incident CVD by 2017 comprised stroke coronary heart (CHD) (myocardial...
OBJECTIVE We prospectively evaluated plasma amino acids (AAs) in early pregnancy and midpregnancy their interplay with phospholipid fatty (FAs) association gestational diabetes mellitus (GDM) risk. RESEARCH DESIGN AND METHODS From a longitudinal cohort of 2,802 individuals, concentrations 24 AAs at 10–14 15–26 weeks (GW) were assessed among 107 GDM case subjects 214 non-GDM control subjects. estimated adjusted odds ratios (OR) 95% CI for the associations joint FAs risk, adjusting risk...
With the rapid development of sports technology, smart wearable devices play a crucial role in athletic training and health management. Sports fatigue is key factor affecting performance. Using to detect onset can optimize training, prevent excessive resultant injury, increase efficiency safety. However, current sensing are often uncomfortable imprecise. Furthermore, stable methods for detection not yet established. To address these challenges, this paper introduces 3D printing deep learning...
Abstract Healthy maternal diets during pregnancy are an important protective factor for pregnancy‐related outcomes, including gestational weight gain (GWG) and birth outcomes. We prospectively examined the associations of dietary diversity diet quality, using Minimum Dietary Diversity Women (MDD‐W) Prime Diet Quality Score (PDQS), with GWG outcomes among women enrolled in a trial Tanzania ( n = 1190). MDD‐W PDQS were derived from baseline food frequency questionnaire. monthly followed until...
Abstract Healthy dietary patterns, such as the alternate Mediterranean diet and Eating Index, benefit cardiometabolic health. However, several food components of these patterns are primary sources environmental chemicals. Here, using data from a racially ethnically diverse US cohort, we show that healthy pattern scores were positively associated with plasma chemical exposure in pregnancy, particularly for Index polychlorinated biphenyls per- poly-fluoroalkyl substances. The associations...
In this report, we introduce Qwen2.5, a comprehensive series of large language models (LLMs) designed to meet diverse needs. Compared previous iterations, Qwen 2.5 has been significantly improved during both the pre-training and post-training stages. terms pre-training, have scaled high-quality datasets from 7 trillion tokens 18 tokens. This provides strong foundation for common sense, expert knowledge, reasoning capabilities. post-training, implement intricate supervised finetuning with...
Abstract Background Appropriate gestational weight gain (GWG) is important for optimal pregnancy outcomes. This study prospectively evaluated the associations between GWG during second and third trimesters of adverse outcomes in an urban Tanzanian cohort. Methods We used data from a randomized clinical trial conducted among pregnant women recruited by 27 weeks gestation Dar es Salaam, Tanzania (N = 1230). Women’s was measured at baseline monthly antenatal visits. Weekly rate calculated...
Abstract Background Early pregnancy weights are needed to quantify gestational weight gain accurately. Different methods have been used in previous studies impute early-pregnancy weights. However, no systematically compared imputed accuracy across different imputation techniques. This study aimed compare four methodological approaches imputing weight, using repeated measures of collected from two cohorts Tanzania. Methods The mean ages at enrollment were 17.8 weeks for Study I and 10.0 II....
Background: The Cognitive role of untreated type 2 diabetes mellitus (T2DM) has been less well substantiated. Objective: We sought to explore the prospective association T2DM and with cognitive function among middle-aged older Chinese adults. Methods: Data 7,230 participants without baseline brain damage/mental retardation, or memory-related diseases in China Health Retirement Longitudinal Study (CHARLS) from 2011– 2012 2015, were analyzed. Fasting plasma glucose self-reported information on...
Abstract Background Increasing maternal glycaemia across the continuum during pregnancy may predispose offspring to subsequent cardiometabolic risk later in life. However, evidence of long-term impacts glycemic status on amino acid (AA) profiles is scarce. We aimed investigate association between antenatal and mid-childhood profiles, which are emerging biomarkers. Methods Data were drawn from Growing Up Singapore Towards healthy Outcomes (GUSTO) study, a multi-ethnic Asian birth cohort. A...
Purpose The Taicang and Wuqiang cohort study (TAWS) was established to examine the association between early-life nutrition children’s health, explore potential roles of maternal metabolites microbiota in health two different regions China. Participants A total 7041 mother–child pairs were recruited during early pregnancy (n=4035, 57.3%) or delivery phase (n=3006, 42.7%) from centres hospitals Wuqiang. Mother–child followed up three times pregnancy, once delivery, 7–10 3 years after...
Results of studies assessing intrauterine device (IUD) use and ovarian cancer risk are inconsistent. We examined the association between IUD use, including duration, type timing using three population-based studies. Data from New England Case-Control Study (NEC) two prospective cohort studies, Nurses' Health Studies (NHS/NHSII), were included in analysis. Information on was collected by in-person interview NEC biennial questionnaire NHS/NHSII. used unconditional logistic regression to...
Background and aimsMetabolomic profiling is a systematic approach to identifying biomarkers for dietary patterns. Yet, metabolomic markers patterns in pregnant individuals have not been investigated. The aim of this study was identify plasma metabolite panels that are associated with the Mediterranean diet individuals.MethodsThis prospective 186 who had both intake profiles measured from Fetal Growth Studies-Singletons cohort. Dietary intakes during peri-conception/1st trimester second were...
Abstract Background: Except for a documented increase in osteoprotegerin (OPG) concentrations with older age, data on determinants of soluble Receptor Activator Nuclear Factor κB (sRANKL) and OPG women are limited. We evaluated reproductive lifestyle factors as potential sources variation circulating sRANKL pre- postmenopausal women. Methods: This study includes 2,016 controls [n = 1,552 (76%) postmenopausal, n 757 (38%) using hormone therapy (PMH)] from breast cancer case–control nested the...
OBJECTIVE We examined lifestyle factors with midlife weight change according to history of gestational diabetes mellitus (GDM) in a large longitudinal female cohort. RESEARCH DESIGN AND METHODS In the Nurses’ Health Study II, we categorized changes within 4-year periods and estimated their associations concurrent body (kilograms) among parous women after age 40 years by GDM status (N = 54,062; 5.3% GDM) for following: diet quality (Alternate Healthy Eating Index [AHEI]), leisure-time...