A5100780756- Cardiac electrophysiology and arrhythmias
- Ion channel regulation and function
- Mental Health Treatment and Access
- Functional Brain Connectivity Studies
- Cardiac Arrhythmias and Treatments
- Bipolar Disorder and Treatment
- Treatment of Major Depression
- Neuroscience and Neuropharmacology Research
- Heart Rate Variability and Autonomic Control
- Atrial Fibrillation Management and Outcomes
- Electrochemical Analysis and Applications
- Peripheral Artery Disease Management
- Mental Health Research Topics
- Pain Mechanisms and Treatments
- Renal and Vascular Pathologies
- Schizophrenia research and treatment
- Tryptophan and brain disorders
- Blood Pressure and Hypertension Studies
- Potassium and Related Disorders
- Folate and B Vitamins Research
- EEG and Brain-Computer Interfaces
- Neural dynamics and brain function
- Optimism, Hope, and Well-being
- Stress Responses and Cortisol
- Diet and metabolism studies
Shanghai Mental Health Center
2018-2025
Shanghai Jiao Tong University
2003-2025
Vanderbilt University Medical Center
2003-2024
Second Affiliated Hospital of Zhejiang University
2022-2023
Guizhou Normal University
2021-2022
Changzhi Medical College
2022
University of British Columbia
2020-2021
Heilongjiang University of Chinese Medicine
2021
Nanchang University
2020
Zunyi Medical University
2020
Background Torsade de pointes often occurs with underlying hypokalemia and bradycardia. A common effect of many drugs producing torsade is block the rapidly activating component cardiac delayed rectifier (I Kr ). In this study, we evaluated changing extracellular potassium ([K + ] o ) on I by nonspecific agent quinidine specific blocker dofetilide. Methods Results was measured in AT-1 cells, where contaminating outward currents are absent. The drug concentration 50% inhibition tails (IC 50...
Brugada syndrome is a genetic disease associated with sudden cardiac death that characterized by ventricular fibrillation and right precordial ST segment elevation on ECG. Loss-of-function mutations in SCN5A, which encodes the predominant sodium channel alpha subunit NaV1.5, can cause conduction disease. However, SCN5A are not detected majority of patients these syndromes, suggesting other genes or modify presentation disorders. Here, we investigated SCN1B, function-modifying beta1 subunit,...
The electromechanical effects of UK-68,798 (UK), a novel class III antiarrhythmic drug, were studied in guinea pig and rat papillary muscles (PMs) atria vitro using conventional microelectrode technique. UK (10−8-10−6M) prolonged the action potential duration (APD) by 21–58% effective refractory period parallel, without affecting resting or maximum rate depolarization PM stimulated at 1 Hz. increased contractile force prolonging time to peak relaxation. In comparison, 5 ± 10−5Md-sotalol was...
Male hypogonadism, arising from a range of etiologies including androgen-deprivation therapies (ADTs), has been reported as risk factor for acquired long-QT syndrome (aLQTS) and torsades de pointes (TdP). A full description the clinical features aLQTS associated with ADT underlying mechanisms is lacking.We searched international pharmacovigilance database VigiBase men (n=6 560 565 individual case safety reports) presenting aLQTS, TdP, or sudden death ADT. In cardiomyocytes derived induced...
The characteristic ECG pattern of ST-segment elevation in V1 and V2 the Brugada syndrome is dynamic; it often intermittently present affected individuals can be unmasked by sodium channel blockers, including antiarrhythmic drugs tricyclic antidepressants. We report here 2 patients who developed after administration lithium, a commonly used drug not previously reported to block cardiac channels.Lithium induced transient (type 1 pattern) right precordial leads at therapeutic concentrations...
Quinolones are clinically important antibiotic drugs. One quinolone antibiotic, sparfloxacin (SPX), has been recently reported to increase the QT interval, and another quinolone, grepafloxacin (GRX), was withdrawn because it induced torsade de pointes (TdP), a polymorphic ventricular tachycardia (VT) linked excessive interval prolongation. To determine whether SPX, GRX, other developed quinolones, gatifloxacin (GAT) moxifloxacin (MOX), have similar, potentially deleterious, properties we...
Abstract Single Nucleotide Polymorphic (SNP) variations of proinflammatory cytokines such as Tumor Necrosis Factor-α (TNF-α) have been reported to be closely associated with the major depressive disorder (MDD). However, it is unclear if genetic burden adversely affects regional gray matter volume in patients MDD. The aim this study was test whether rs1799724, an SNP TNF-α, contributes neuroanatomical changes In cross-sectional study, a total 144 MDD and 111 healthy controls (HC) well matched...
Cases of QT prolongation and sudden death have been reported with risperidone, a neuroleptic agent increasingly prescribed worldwide. Although hypokalemia was present in some these events, we hypothesized that risperidone may unsuspected electrophysiologic effects predisposing patients to proarrhythmia. In six isolated guinea pig hearts, elicited cardiac repolarization: action potential duration increased from baseline value 128 ms ± 5 147 (15%) 1 μM during pacing at 250-ms cycle length,...
This study aimed to explore the executive function of healthy elderly Chinese people. A sample 58 aged 60 and over was recruited from Guangzhou in China. They were divided into two age groups, a younger group (aged 60-70) an older 70). Executive measured by battery seven tests which assumed capture specific components function. The initiation (Hayling Sentence Completion Test (HSC)), sustained attention (Monotone Counting Test), switching flexibility (word fluency modified Wisconsin Card...
Abstract Background High fat diet impact transcription of hepatic genes responsible for drug metabolism and pharmacokinetics. Until now, researches just focused on a couple specific without global profile showing. Age-dependent manner was also not noted well. This study aims to investigate the high effect transcriptome pharmacokinetic system in mouse livers show age-dependent evidence. Methods C57BL/6 male mice were used this experiment. treat 16 38 weeks. Serum total cholesterol, low...
Abstract Bipolar disorder (BD) and major depressive (MDD) have both common distinct clinical features, that pose conceptual challenges in terms of their diagnostic boundaries practical difficulties optimizing treatment. Multivariate machine learning techniques offer new avenues for exploring these based on neuroanatomical features. Brain structural data were obtained at 3 T from a sample 90 patients with BD, 189 MDD, 162 healthy individuals. We applied sparse partial least squares...
Objectives Much has been written documenting the positive association between core self-evaluation and adolescents' subjective wellbeing, but little is known about mediating moderating mechanisms which underlay this relationship. This study constructed a moderated mediation model to examine whether meaning in life mediated relationship process was by self-esteem. Methods A sample of 1,185 adolescents (11–17 years age, 51.3% females) completed Core Self-Evaluation Scale (CSES), Meaning Life...
Measurement-based care (MBC) is an evidence-based practice for depression, but its use by clinicians remains low. Enhanced MBC (eMBC), which uses digital technologies, can help to facilitate the of and patients. Understanding factors that act as barriers drivers implementation eMBC important support design strategies, promoting uptake
Abstract Backgrounds The Positive and Negative Suicide Ideation (PANSI) Inventory is a widely used self-report questionnaire which designed to comprehensively evaluate the protective factors negative risk associated with suicidal behaviors among adolescents. present study aimed psychometric properties measurement invariance of Chinese version PANSI in non-clinical sample Methods Participants ( N = 1198) were middle school students aged 11–17 years (44.8% boys 51.9% girls, 3.3% missing...
The chronotropic effects of a novel class III antiarrhythmic drug, UK‐68,798, and the β‐adrenoceptor blocker, propranolol, for comparison, were studied on spontaneously beating right atria isolated from guinea‐pigs in absence presence increasing concentrations isoprenaline (10 −10 –10 −4 m ). UK‐68,798 −9 −5 ) decreased spontaneous atrial rate by 6–21%. Propranolol −8 −6 also had negative but significantly smaller effect. dose‐dependently reduced maximal positive effect induced isoprenaline,...
Almost half of patients with major depressive disorder (MDD) also have clinically meaningful levels anxiety. Anxious depression is a distinct clinical subtype MDD, which has poor response to pharmacotherapy; however, the neural mechanisms behind are largely unknown. In present study, we explored white matter (WM) integrity traits anxious in first-episode and medication-free (medication-naïve medication washout) Chinese young adult by detecting differences diffusion tensor imaging (DTI)...