A5063177685- Drug-Induced Adverse Reactions
- Pharmacovigilance and Adverse Drug Reactions
- Autoimmune Bullous Skin Diseases
- Urticaria and Related Conditions
- Cancer Immunotherapy and Biomarkers
- Contact Dermatitis and Allergies
- Chronic Lymphocytic Leukemia Research
- Biosimilars and Bioanalytical Methods
- Cardiac electrophysiology and arrhythmias
- Systemic Lupus Erythematosus Research
- Pharmaceutical studies and practices
- Heparin-Induced Thrombocytopenia and Thrombosis
- CAR-T cell therapy research
- Colorectal Cancer Treatments and Studies
- Immunodeficiency and Autoimmune Disorders
- Eosinophilic Disorders and Syndromes
- Acne and Rosacea Treatments and Effects
- Peripheral Neuropathies and Disorders
- Herpesvirus Infections and Treatments
- Dermatology and Skin Diseases
- Blood disorders and treatments
- Lymphoma Diagnosis and Treatment
- PARP inhibition in cancer therapy
- Health Systems, Economic Evaluations, Quality of Life
- Drug-Induced Ocular Toxicity
Pitié-Salpêtrière Hospital
2016-2025
Sorbonne Université
2016-2025
Assistance Publique – Hôpitaux de Paris
2015-2025
Université Paris-Est Créteil
2017-2025
Inserm
2018-2024
Fondation pour l’innovation en Cadiométabolisme et Nutrition
2018-2024
Centre de Recherche Saint-Antoine
2022-2024
Hôpital Charles-Foix
2014-2024
Centre Hospitalier Universitaire de Nantes
2024
Hôpital Intercommunal de Créteil
2024
<h3>Background</h3> Immune checkpoint inhibitors (ICI) produce durable antitumor responses but provoke autoimmune toxicities, including uncommon potentially devastating neurologic toxicities. The clinical features, the spectrum, timing, and outcomes, of ICI-induced toxicities are not well characterized. <h3>Methods</h3> We performed disproportionality analysis using Vigibase, World Health Organization pharmacovigilance database, comparing adverse event (AE) reporting in patients receiving...
Background: Ibrutinib is a Bruton tyrosine kinase inhibitor with remarkable efficacy against B-cell cancers. also increases the risk of atrial fibrillation (AF), which remains poorly understood. Methods: We performed electrophysiology studies on mice treated ibrutinib to assess inducibility AF. Chemoproteomic analysis cardiac lysates identified candidate targets, were further evaluated in genetic mouse models and additional pharmacological experiments. The pharmacovigilance database,...
Increasing number of Janus kinase (JAK) inhibitors have been approved for chronic haematopoietic neoplasms and inflammatory/autoimmune diseases. We aimed to assess safety the first three JAK inhibitors: ruxolitinib, tofacitinib baricitinib. In this retrospective observational study, pharmacovigilance data were extracted from World Health Organization database. Adverse events are classified according Medical Dictionary Regulatory Activities hierarchy. Until February 28, 2021, all Individual...
While multiple pharmacological drugs have been associated with myocarditis, temporal trends and overall mortality not reported. Here we report the spectrum main features of 5108 reports drug-induced in a worldwide pharmacovigilance analysis, comprising more than 21 million individual-case-safety from 1967 to 2020. Significant association between myocarditis suspected drug is assessed using disproportionality analyses, which use Bayesian information component estimates. Overall, identify 62...
BackgroundImmune-checkpoint inhibitors (ICI) have revolutionized cancer treatment by harnessing the immune system but ICI can induce life-threatening immune-related adverse events (irAE) affecting every organ.MethodsWe extracted irAE from VigiBase, international pharmacovigilance database, first reported in 2008 until 01/2023 to characterize reporting trends, clinical features, risk factors and outcomes.FindingsWe distinguished 25 types of (n = 50,347cases, single irAE/case 84.9%). Cases...
Fixed drug eruption (FDE) is one of the most typical cutaneous adverse reactions. This localized drug-induced reaction characterized by its relapse at same sites. Few large series FDE are reported. The aim this study was to retrospectively collect and analyse well informed cases observed in a hospital setting. involved 17 academic clinical centers. A French nation-wide retrospective multicentric carried out on 3-year-period from 2005 2007 collecting data seventeen departments dermatology...
Abstract Immune checkpoint inhibitors have improved outcomes for patients with numerous hematological and solid cancers. Hematologic toxicities been described, but the spectrum, timing, clinical presentation of these complications are not well understood. We used World Health Organization's pharmacovigilance database individual-case-safety-reports (ICSRs) adverse drug reactions, VigiBase, to identify cases hematologic complicating immune inhibitor therapy. identified 168 ICSRs...
Journal Article Linear IgA bullous dermatosis: comparison between the drug‐induced and spontaneous forms Get access J. Chanal, Chanal Department of Dermatology Assistance Publique–Hôpitaux de Paris (APHP) Groupe Hospitalier Henri‐Mondor 51 Avenue du Maréchal‐de‐Lattre‐de‐Tassigny 94010 Créteil France Search for other works by this author on: Oxford Academic Google Scholar S. Ingen‐Housz‐Oro, Ingen‐Housz‐Oro Correspondence Saskia Ingen‐Housz‐Oro. E‐mail: saskia.oro@hmn.aphp.fr N. Ortonne,...
Immune checkpoint inhibitors (ICIs) have transformed cancer therapy but may also trigger autoimmune adverse drug reactions (ADRs) referred to as immune-related events (irAEs). Although endocrinopathies are among the most common form of irAEs, primary adrenal insufficiency (PAI) is infrequent and has only been published in case reports. The aim this study was identify characterize main features PAI-irAE.Suspected PAI-irAE cases were identified using VigiBase, World Health Organization's...
Objective Drug-induced lupus (DIL) is an idiosyncratic side effect of treatments in which symptoms overlap with those systemic erythematosus (SLE). The spectrum DIL constantly evolves that the pharmacopoeia. Here, we used VigiBase, WHO global individual case safety reports (ICSRs) database, to identify main drugs associated DIL. Methods We analysed all ICSRs classified as ‘systemic erythematosus’ according Medical Dictionary for Drug Regulatory Activities term (preferred level) VigiBase....
Abstract Background There is a documented association between drug exposure and sarcoidosis‐like reactions. In this study, we used the largest pharmacovigilance database to describe drug‐induced sarcoidosis. Methods Data were collected from World Health Organization (WHO) (VigiBase). We excluded steroids vaccines analysis. The primary end‐point was lower of 95% credibility interval for information component (IC 025 ). Results A total 127 reports had significant IC values sarcoidosis, 110...
With the explosion of anticancer drugs, an emerging concern is risk for drug-induced sudden death (SD) via ventricular arrhythmias (VA).
Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare but potentially fatal drug hypersensitivity reaction. To our knowledge, there no international consensus on its severity assessment treatment.
Male hypogonadism, arising from a range of etiologies including androgen-deprivation therapies (ADTs), has been reported as risk factor for acquired long-QT syndrome (aLQTS) and torsades de pointes (TdP). A full description the clinical features aLQTS associated with ADT underlying mechanisms is lacking.We searched international pharmacovigilance database VigiBase men (n=6 560 565 individual case safety reports) presenting aLQTS, TdP, or sudden death ADT. In cardiomyocytes derived induced...