A5091482161- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Bipolar Disorder and Treatment
- Treatment of Major Depression
- Functional Brain Connectivity Studies
- Birth, Development, and Health
- Lung Cancer Diagnosis and Treatment
- Esophageal Cancer Research and Treatment
- Child and Adolescent Psychosocial and Emotional Development
- Electrolyte and hormonal disorders
- Genetics and Neurodevelopmental Disorders
- Medical Imaging Techniques and Applications
- Anesthesia and Neurotoxicity Research
- Advanced Neuroimaging Techniques and Applications
- Erythrocyte Function and Pathophysiology
- Microbial Natural Products and Biosynthesis
- Electroconvulsive Therapy Studies
- Transcranial Magnetic Stimulation Studies
- S100 Proteins and Annexins
- Cardiovascular Health and Risk Factors
- Health, psychology, and well-being
- Hydrogen's biological and therapeutic effects
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Cardiac electrophysiology and arrhythmias
- Maternal Mental Health During Pregnancy and Postpartum
Shandong University
2012-2025
Shandong Provincial Hospital
2012-2025
Shandong First Medical University
2021-2025
Xi'an Jiaotong University
2023
Shanghai Mental Health Center
2015-2021
Shanghai Jiao Tong University
2015-2021
Second Affiliated Hospital of Jilin University
2021
Shanghai First People's Hospital
2018-2019
Centre for Movement Disorders
2018
Shanghai Institute of Hypertension
1990-2001
Abstract Our previous work implied that interleukin 6 (IL6) may be a biological marker for major depressive disorder (MDD). In this study, we performed comprehensive genetic study to determine the association between gene encoding IL6 ( ) and MDD in Han Chinese. There were 50 drug-naïve patients healthy controls undergoing an mRNA expression study. A sample of 772 with 759 used analysis. Next, eQTL analysis identify whether risk SNP(s) is associated brain. results showed have higher levels...
Abstract Single Nucleotide Polymorphic (SNP) variations of proinflammatory cytokines such as Tumor Necrosis Factor-α (TNF-α) have been reported to be closely associated with the major depressive disorder (MDD). However, it is unclear if genetic burden adversely affects regional gray matter volume in patients MDD. The aim this study was test whether rs1799724, an SNP TNF-α, contributes neuroanatomical changes In cross-sectional study, a total 144 MDD and 111 healthy controls (HC) well matched...
Recent research has explored the linkage between major depressive disorder (MDD) and inflammation, especially via altered peripheral blood immune markers. However, relationship several novel leukocyte-derived ratios (LDR) psychological stress in MDD remains uncertain. This study aimed to explore LDR, clinical characteristics, recent life events, childhood maltreatment patients.
Background Adolescence marks a critical transition period, with significant mental health challenges including anxiety and depression symptoms that affect long-term happiness. There has been lack of research exploring the factors mediating adolescent Aims To investigate effects on happiness, as well contributions sociodemographic factors. Methods We recruited 392 adolescents. Anxiety symptoms, happiness were assessed by seven-item Generalized Disorder scale, nine-item Patient Health...
Abstract Bipolar disorder (BD) and major depressive (MDD) have both common distinct clinical features, that pose conceptual challenges in terms of their diagnostic boundaries practical difficulties optimizing treatment. Multivariate machine learning techniques offer new avenues for exploring these based on neuroanatomical features. Brain structural data were obtained at 3 T from a sample 90 patients with BD, 189 MDD, 162 healthy individuals. We applied sparse partial least squares...
The gene encoding cyclohexadienyl dehydratase (denoted pheC) was cloned from Pseudomonas aeruginosa by functional complementation of a pheA auxotroph Escherichia coli. highly expressed in E. coli due to the use high-copy number vector pUC18. P. purified electrophoretic homogeneity. latter enzyme exhibited identical physical and biochemical properties as those obtained for aeruginosa. activity ratios prephenate arogenate remained constant (about 3.3-fold) throughout purification, thus...
Almost half of patients with major depressive disorder (MDD) also have clinically meaningful levels anxiety. Anxious depression is a distinct clinical subtype MDD, which has poor response to pharmacotherapy; however, the neural mechanisms behind are largely unknown. In present study, we explored white matter (WM) integrity traits anxious in first-episode and medication-free (medication-naïve medication washout) Chinese young adult by detecting differences diffusion tensor imaging (DTI)...
Patients with bipolar disorder (BD) and patients major depressive (MDD) have relatively specific temperament structural abnormalities of brain regions related to emotion cognition. However, the effects factors on structure frontal temporal cortex is still unclear. The aims this study were explore differences relationships between characteristics gray matter volume in BD or MDD.T1-weighted magnetic resonance imaging (MRI) data, demographic clinical information obtained from 279 depressed (90...
Abstract Background School attendance problems (SAPs), whether absenteeism or dropout, are strongly associated with poor outcomes for adolescents. We examined multiple variables that influence SAPs to identify potential leverage points improving school attendance. Methods Self-reported and demographic information was collected from 392 adolescents in presenting the general hospital psychological services. PHQ-9 GAD-7 were applied assess severity of depressive anxious symptoms. constructed...
Genome sequence analysis of Streptomyces sp. LZ35 has revealed a large number secondary metabolite pathways, including complete gene cluster for the biosynthesis cyclooctatin. This contains four genes, cotB1-4, located in 5-kb region. Optimization fermentation medium LZ35Δheng (SR107) led to identification cyclooctatin (1) and 16,17-dihydroxycyclooctatin (2), new diterpene. The structures these substances were elucidated on basis 1D-, 2D-NMR, HRESIMS data. Cytotoxicity against MDA-MB-231...
Background Inflammation that is mediated by microglia activation plays an important role in the pathogenesis of depression. Microglia can lead to increase levels proinflammatory cytokines, including TNF-α, which leads neuronal apoptosis specific neural circuits some brain regions, abnormal cognition and treatment-resistant depression (TRD). Protein kinase C (PKC) a key regulator process. We assume abnormality PKC might result activation, apoptosis, significant changes emotional cognitive...