A5071346122- Cardiac electrophysiology and arrhythmias
- Cardiac Arrhythmias and Treatments
- Ion channel regulation and function
- Liver Disease Diagnosis and Treatment
- Drug Transport and Resistance Mechanisms
- Protein Interaction Studies and Fluorescence Analysis
- Pharmacogenetics and Drug Metabolism
- Pulmonary Hypertension Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Heme Oxygenase-1 and Carbon Monoxide
- Cardiovascular Function and Risk Factors
- Atrial Fibrillation Management and Outcomes
- Cardiac pacing and defibrillation studies
- Neonatal Health and Biochemistry
- Nitric Oxide and Endothelin Effects
- Dialysis and Renal Disease Management
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Hemoglobin structure and function
- Lung Cancer Treatments and Mutations
- Metabolism and Genetic Disorders
- Antibiotics Pharmacokinetics and Efficacy
- Pharmacological Effects and Toxicity Studies
- Immune cells in cancer
- Alcohol Consumption and Health Effects
- Cardiac Imaging and Diagnostics
Kumamoto University
2016-2025
Waseda University
1972-2024
Kurume University
2012-2024
Keio University
1954-2023
Hamamatsu University School of Medicine
2014-2023
Fukushima Medical University
2006-2023
Yamagata University
2009-2023
Niigata Prefectural Niigata Minami High School
2016-2023
Niigata University
2013-2022
Suntory Foundation for Life Sciences
2020-2022
This study was undertaken to investigate the efficacy and feasibility of gefitinib for chemotherapy-naïve patients with advanced non-small-cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) mutations.The EGFR gene status in various tumor samples obtained from NSCLC examined by DNA sequencing exons 18 23. Patients mutations received (250 mg/d) alone. The response rate, progression-free survival (PFS), toxicity profile were assessed prospectively.Between June 2004...
Brugada syndrome is a genetic disease associated with sudden cardiac death that characterized by ventricular fibrillation and right precordial ST segment elevation on ECG. Loss-of-function mutations in SCN5A, which encodes the predominant sodium channel alpha subunit NaV1.5, can cause conduction disease. However, SCN5A are not detected majority of patients these syndromes, suggesting other genes or modify presentation disorders. Here, we investigated SCN1B, function-modifying beta1 subunit,...
Background— The metabolic syndrome consists of a cluster atherosclerotic risk factors, many which also have been implicated in the genesis atrial fibrillation (AF). However, precise role development AF is unknown. Methods and Results— This prospective, community-based, observational cohort study was based on an annual health check-up program Japan. We studied 28 449 participants without baseline AF. used 2 different criteria for syndrome—the guidelines National Cholesterol Education Program...
Recombinant wild-type human serum albumin (rHSA), the single-residue mutants R410A, Y411A, Y411S and Y411F double mutant R410A/Y411A were produced using a yeast expression system. The recombinant proteins correctly folded, as they had same stability towards guanidine hydrochloride CD spectrum HSA isolated from (native HSA). Thus global structures of are probably very similar to that native HSA. We investigated, by ultrafiltration CD, high-affinity binding two representative site II ligands,...
The degree of oxidized cysteine (Cys) 34 in human serum albumin (HSA), as determined by high performance liquid chromatography (HPLC), is correlated with oxidative stress related pathological conditions. In order to further characterize the oxidation Cys34-HSA at molecular level and develop a suitable analytical method for rapid sensitive clinical laboratory analysis, use electrospray ionization time-of-flight mass spectrometer (ESI-TOFMS) was evaluated. A marked increase cysteinylation...
Abstract Skeletal muscle atrophy, referred to as sarcopenia, is often observed in chronic kidney disease (CKD) patients, especially patients who are undergoing hemodialysis. The purpose of this study was determine whether uremic toxins involved CKD-related skeletal atrophy. Among six protein-bound toxins, indole containing compounds, indoxyl sulfate (IS) significantly inhibited proliferation and myotube formation C2C12 myoblast cells. IS increased the factors related breakdown, such reactive...
Background: We have previously demonstrated that long-term inhibition of Rho-kinase ameliorates pulmonary arterial hypertension (PAH) in animal models. In the present study, we examined clinical effects mid-term oral treatment with an extended release formulation AT-877 (fasudil hydrochloride), a specific inhibitor (AT-877ER) on PAH. Methods and Results: 23 PAH patients were treated either placebo (10/2 females/males, 51±16 years, idiopathic (IPAH) 6, associated connective tissue disease...
Abstract The turnover of cerebral glycogen in mice has been investigated by using [U‐ 14 C]glucose as a precursor. time required for total and limit dextrin determined normal animals given phenobarbital or hydrocortisone. In all 3 groups, the was twice that glycogen. Phenobarbital increased approximately 2‐fold, whereas hydrocortisone diminished both fractions to one‐half. accumulation during anesthesia (2·5‐fold) is attributed decrease rate phosphorolysis rather than elevated glycogenesis....
Background— The D1275N SCN5A mutation has been associated with a range of unusual phenotypes, including conduction disease and dilated cardiomyopathy, as well atrial ventricular tachyarrhythmias. However, when is studied in heterologous expression systems, most studies show near-normal sodium channel function. Thus, the relationship variant to clinical phenotypes remains uncertain. Methods Results— We identified patient flutter, standstill, disease, sinus node dysfunction. There was no major...
This study aimed to evaluate the effects of green tea on pharmacokinetics and pharmacodynamics β-blocker nadolol. Ten healthy volunteers received a single oral dose 30 mg nadolol with or water after repeated consumption (700 ml/day) for 14 days. Catechin concentrations in plasma were determined. Green markedly decreased maximum concentration (Cmax) area under concentration–time curve (AUC0–48) by 85.3% 85.0%, respectively (P < 0.01), without altering renal clearance The systolic blood...
Abstract Background Chronic kidney disease (CKD) patients experience skeletal muscle wasting and decreased exercise endurance. Our previous study demonstrated that indoxyl sulfate (IS), a uremic toxin, accelerates atrophy. The purpose of this was to examine the issue whether IS causes mitochondria dysfunction IS‐targeted intervention using AST‐120, which inhibits accumulation, or mitochondria‐targeted L‐carnitine teneligliptin, dipeptidyl peptidase‐4 inhibitor retains function alleviates...
Background: Dyslipidemia, an important risk factor for cardiovascular disease, may be associated with atrial fibrillation (AF). Cross-sectional studies that have examined this association, however, produced controversial results, and few longitudinal been conducted. Methods Results: Using annual health examinations in Japan, the association between lipid profile of new-onset AF was investigated general population. A total 28,449 individuals who did not at baseline were included study. During...
The interaction of imatinib mesilate with P-glycoprotein (P-gp) was examined using pig kidney epithelial LLC-PK1 cells versus L-MDR1 cells, which overexpress human P-gp on the apical membrane. basal-to-apical transport in significantly exceeded that parental LLCPK1 cells. intracellular accumulation after its basal application to and 35% 15%, respectively. A modulator, cyclosporin A, inhibited also increased by A. rhodamine 123 efflux assay showed K562/DXR P-gp, could be blocked markedly a...
On October 23, 2004, a major earthquake, which registered 6.8 on the Richter scale, occurred in Niigata Prefecture Japan. Emotional stress is important as trigger of transient left ventricular apical ballooning (so-called 'Takotsubo' cardiomyopathy), but its incidence and clinical profile immediately after natural disaster have not been fully elucidated.'Takotsubo' cardiomyopathy was diagnosed 16 patients (1 man, 15 women, mean age 71.5 years) within 1 month earthquake. Of them, 13 (81%)...