A5101880153- Cardiovascular Function and Risk Factors
- Lymphoma Diagnosis and Treatment
- Peripheral Artery Disease Management
- Cardiac Imaging and Diagnostics
- Chronic Lymphocytic Leukemia Research
- Cerebrovascular and Carotid Artery Diseases
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Heart Failure Treatment and Management
- Atrial Fibrillation Management and Outcomes
- Angiogenesis and VEGF in Cancer
- Cardiac electrophysiology and arrhythmias
- Cardiac Structural Anomalies and Repair
- Acute Myeloid Leukemia Research
- Cardiac Arrhythmias and Treatments
- Peptidase Inhibition and Analysis
- Cancer Genomics and Diagnostics
- Mechanical Circulatory Support Devices
- Coronary Interventions and Diagnostics
- Acute Lymphoblastic Leukemia research
- Advanced Glycation End Products research
- Protease and Inhibitor Mechanisms
- Cardiovascular Disease and Adiposity
- Lipoproteins and Cardiovascular Health
- Cholesterol and Lipid Metabolism
- Myeloproliferative Neoplasms: Diagnosis and Treatment
Mie Chuo Medical Center
2024-2025
Nagasaki University
2023-2024
Hokkaido University
2004-2023
St. Luke's International Hospital
2023
Kyoto Prefectural University of Medicine
1995-2023
Asahi Breweries (Japan)
2022
Saitama Medical University
2004-2021
Saitama Medical University Hospital
2021
Hokkaido University Hospital
1984-2021
Kagoshima City Hospital
2021
Background There have been a number of recent reports on the use autologous bone marrow implantation (BMI) in treatment peripheral arterial disease, with clinical response rate approximately 70%. However, factors that influence efficacy not yet clarified. We analyzed relationship between implanted cells and BMI. Methods Results Eight patients arteriosclerosis obliterans were treated Bone was aspirated from ilium (500-1,000 ml), mononuclear separated then implanted. The effectiveness BMI...
On October 23, 2004, a major earthquake, which registered 6.8 on the Richter scale, occurred in Niigata Prefecture Japan. Emotional stress is important as trigger of transient left ventricular apical ballooning (so-called 'Takotsubo' cardiomyopathy), but its incidence and clinical profile immediately after natural disaster have not been fully elucidated.'Takotsubo' cardiomyopathy was diagnosed 16 patients (1 man, 15 women, mean age 71.5 years) within 1 month earthquake. Of them, 13 (81%)...
Background:Insomnia is associated with incident heart failure (HF), but the clinical significance and impact of insomnia on HF remain unclear.Methods Results:Consecutive 1,011 patients admitted for were divided into 2 groups according to presence insomnia: (insomnia group, n=519) without (non-insomnia n=492). We compared (1) cardiac event rates including death worsening HF; (2) underlying background laboratory data, echocardiographic cardiopulmonary exercise test between groups. On...
Aims Liver dysfunction due to heart failure (HF) is often referred as cardiac or congestive hepatopathy. The composite Model for End-Stage Disease excluding INR (MELD-XI) a robust scoring system of liver function, and high score associated with poor prognosis in advanced HF patients transplantation and/or ventricular assist device. However, the impact MELD-XI on general remains unclear. Methods Results We retrospectively analyzed 562 who were admitted our hospital treatment decompensated HF....
Cheyne-Stokes respiration (CSR) is often observed in patients with chronic heart failure (CHF). Although adaptive servo ventilation (ASV) effective for CSR, it remains unclear whether ASV improves the cardiac function and prognosis of CHF CSR.Sixty CSR (mean left ventricular ejection fraction 38.7%, mean apnea hypopnea index 36.8 times/hour, central 19.1 times/hour) were enrolled this study. Patients divided into two groups: 23 treated (ASV group) 37 without (Non-ASV group). Measurement...
Patients with fulminant myocarditis (FM) often present cardiogenic shock and require mechanical circulatory support, including extracorporeal membrane oxygenation (ECMO) ventricular assist device (VAD) implantation. This study sought to clarify the determinants of successful weaning from ECMO in FM patients.We studied 37 consecutive patients supported by as initial form support between January 1995 December 2014 our hospital. Twenty-two (59%) were successfully weaned ECMO, while 15 (41%)...
Serum uric acid is a predictor of cardiovascular mortality in heart failure with reduced ejection fraction. However, the impact on preserved fraction (HFpEF) remains unclear. Here, we investigated association between hyperuricemia and HFpEF patients. Consecutive 424 patients, who were admitted to our hospital for decompensated diagnosed as having HFpEF, divided into two groups based presence (serum ≥7 mg/dl or taking antihyperuricemic agents). We compared patient characteristics,...
A 52-year-old man with hypertension presented sudden-onset lower back pain and numbness in both limbs. Imaging revealed a Stanford type aortic dissection extending from the ascending aorta to left common iliac artery, compression of celiac artery partial thrombosis superior inferior mesenteric arteries. The patient underwent replacement surgery. On postoperative day 3, he developed intestinal ischemia, requiring subtotal colectomy. By 10, fever hypotension, subsequent imaging ischemic...
Abstract Background Higher body mass index ( BMI ) is associated with incident heart failure HF ), but paradoxically better prognosis, recognized as the obesity paradox in . However, impact of on detailed prognosis and mechanism remain still unclear. Materials methods We researched consecutive 648 patients admitted for follows: underweight < 18·5 kg/m 2 , n = 86), normal (18·5 ≤ 25, 380), overweight (25 30, 147) obese (30 35) compared results from their laboratory tests echocardiography....
ABSTRACT. Preβ1-HDL is a minor HDL subfraction that acts as an efficient initial acceptor of cell-derived free cholesterol. During 37°C incubation, plasma preβ1-HDL decreases over time due to its conversion α-migrating by lecithin:cholesterol acyltransferase (LCAT). This may be delayed in hemodialysis patients who have decreased LCAT activity. To clarify whether LCAT-dependent patients, concentrations were determined 45 and gender-matched control subjects before after incubation with without...
alpha s-Plasmin inhibitor (alpha 2PI), one of the serine protease inhibitors in plasma, was expressed baby hamster kidney (BHK) cell line. The expression vector constructed with its genomic DNA and cDNA, transfected into BHK cells by calcium phosphate method. recombinant 2PI which secreted from estimated SDS-PAGE to have a molecular mass 67 kDa, is indistinguishable that normal plasma 2PI. leader peptide 12 amino acids retained at terminus This finding suggests has pre-pro type processing...
We have isolated overlapping phage genomic clones covering an area of 26 kilobases that encodes the human alpha 2-plasmin inhibitor. The inhibitor gene contains 10 exons and 9 introns distributed over approximately 16 DNA. To our knowledge, number is highest yet reported for a member serine protease (serpin) superfamily. All are located in 5'-half corresponding mRNA. 5'-untranslated region leader sequence interrupted by 3 totaling equal to 6 kilobases. A "TATA box" 17 nucleotides upstream...
Background: Cardiac troponins are independent predictors of cardiac mortality in patients with heart failure (HF). Recently, elevation was described non-cardiac diseases such as stroke and infection, among others, but it remains unclear whether high-sensitivity troponin T (hs-TnT) predicts HF patients. Methods Results: Four-hundred forty-four consecutive admitted to hospital for the treatment decompensated were divided into 2 groups based on median hs-TnT: group L (<0.028ng/ml, n=220) H...
Background:The impact of peripheral artery disease (PAD) on heart failure (HF) prognosis remains unclear.Methods and Results:A total 388 consecutive decompensated HF patients were divided into 2 groups based the presence PAD: with PAD (PAD group, n=101, 26.0%) without (non-PAD n=287, 74.0%). We compared clinical features, echocardiographic parameters, cardiopulmonary exercise testing results, laboratory findings, as well cardiac, non-cardiac, all-cause mortality between groups. The non-PAD...
Aims: High mobility group box 1 (HMGB1) is a DNA-binding protein secreted into the extracellular space from necrotic cells that acts as cytokine. We examined role of HMGB1 in angiogenesis bone marrow-derived heart using transgenic mice exhibiting cardiac-specific overexpression (HMGB1-TG).Methods: HMGB1-TG and wild-type littermate (WT) were lethally irradiated injected with marrow green fluorescent through tail vein. After transplantation, left anterior descending artery was ligated to...
Regulation of squalene epoxidase (SE) gene expression was studied in comparison with those 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase and low density lipoprotein (LDL) receptor. An increased SE mRNA protein content mouse L929 cells grown 10% lipoprotein-deficient fetal bovine serum (LPDS) for 48 h found by performing immunoblot Northern blot analyses when compared the culture presence (FBS). The same results levels were seen using human cell lines HepG2, HeLa, Chang liver cells....