A5017297640- Autoimmune and Inflammatory Disorders Research
- Tryptophan and brain disorders
- Systemic Lupus Erythematosus Research
- Stress Responses and Cortisol
- Immune Cell Function and Interaction
- Treatment of Major Depression
- Bipolar Disorder and Treatment
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Inflammation biomarkers and pathways
- Otitis Media and Relapsing Polychondritis
- Mental Health Research Topics
- Phagocytosis and Immune Regulation
- Inflammasome and immune disorders
- Kawasaki Disease and Coronary Complications
- Neuroinflammation and Neurodegeneration Mechanisms
- Epigenetics and DNA Methylation
- Platelet Disorders and Treatments
- Erythrocyte Function and Pathophysiology
- Rheumatoid Arthritis Research and Therapies
- Hippo pathway signaling and YAP/TAZ
- Streptococcal Infections and Treatments
- Ferroptosis and cancer prognosis
- Infective Endocarditis Diagnosis and Management
- RNA modifications and cancer
- Monoclonal and Polyclonal Antibodies Research
Shanghai Jiao Tong University
2016-2025
Ruijin Hospital
2019-2025
Shanghai Mental Health Center
2016-2024
Guangzhou University of Chinese Medicine
2024
Shanghai Sixth People's Hospital
2020-2023
Shanghai First People's Hospital
2019-2023
Xinjiang Medical University
2022
State Key Laboratory of Oncogene and Related Genes
2020-2021
Nanjing Medical University
2021
Fudan University
2021
Hyperferritinemic syndrome, an overwhelming inflammatory condition, is characterized by high ferritin levels, systemic inflammation and multi-organ dysfunction, but the pathogenic role of remains largely unknown. Here we show in animal model that administration leads to hepatic excessive neutrophil leukocyte infiltration extracellular trap (NET) formation liver tissue. Ferritin-induced NET depends on expression peptidylarginine deiminase 4 elastase reactive oxygen species production....
Osteoarthritis (OA) is characterized by cartilage degradation, inflammatory responses, and osteophyte formation. Matrix metalloproteinase 13 (MMP13) a hallmark of OA development, increased MMP13 expression closely associated with extracellular matrix degradation. varies significantly at different stages progression. While cyclooxygenase 2 (COX-2) inhibitors are commonly used to treat OA, their long-term systemic administration increases the risks adverse effects. Therefore, aim achieving...
Recent studies have revealed that numerous oncogenic long non-coding RNAs (lncRNAs) play pivotal roles in pancreatic ductal adenocarcinoma (PDAC) progression, but little is known about tumor-suppressive lncRNAs PDAC. This study was conducted to evaluate the function of LINC01197 PDAC progression and investigate detailed mechanisms.LncRNA microarray used identify differentially expressed FOXO1-overexpressing PANC1 cells. expression evaluated by quantitative PCR, Northern blotting,...
Abstract Liver fibrosis, a consequence of unhealthy modern lifestyles, has growing impact on human health, particularly in developed countries. Here, we have explored the anti‐fibrotic effects propylene glycol alginate sodium sulphate (PSS), natural extract from brown algae, fibrotic mice and cell models. Thus, established bile duct ligature carbon tetrachloride mouse models LX‐2 with or without PSS treatment. pathological sections relevant indicators serum liver tissues were examined....
Abstract Hepatocellular carcinoma (HCC) is a globally prevailing cancer with low 5-year survival rate. Little known about its intricate gene expression profile. Single-cell RNA sequencing an indispensable tool to explore the genetic characteristics of HCC at more detailed level. In this study, we profiled single cells from human tumor and para-tumor tissues using Smart-seq 2 method. Based on differentially expressed genes, identified heterogeneous subclones in tissues, including five two...
Abstract Our previous work implied that interleukin 6 (IL6) may be a biological marker for major depressive disorder (MDD). In this study, we performed comprehensive genetic study to determine the association between gene encoding IL6 ( ) and MDD in Han Chinese. There were 50 drug-naïve patients healthy controls undergoing an mRNA expression study. A sample of 772 with 759 used analysis. Next, eQTL analysis identify whether risk SNP(s) is associated brain. results showed have higher levels...
The catastrophic outbreak of coronavirus disease 2019 (COVID-19) is currently a public emergency. Adult-onset Still’s (AOSD) an autoinflammatory characterized by life-threatening complications. Systemic hyperinflammation and cytokine storm play critical role in the pathogenesis both COVID-19 AOSD. We aimed to compare similarities differences focusing on ferritin levels between severe active A literature search was performed using databases PubMed, EMBASE, Web Science collect including IL-1β,...
Adult-onset Still's disease (AOSD) is a rare but clinically well-known auto-inflammatory disorder. Cytokine storm, the hallmark of AOSD, mediated by neutrophil hyperactivation and enhanced extracellular trap (NET) formation. Type I interferons (IFNs), having primary role in initiation proinflammation responses, can induce subsequent inflammatory cytokine production. However, type IFNs AOSD unclear. Indeed, high levels IFN-α IFN-β expression are presented patients. In this investigation,...
Adult-onset Still's disease (AOSD) is a systemic autoinflammatory characterized by innate immune system activation, with high risk for macrophage activation syndrome (MAS). MAS development associated monocyte/macrophage and cytokine storm. Monocytes consist of three different subsets, classical monocytes (CMs, CD14
Abstract Glial damage and immune dysfunction are involved in pathogenesis of schizophrenia. However, interaction between glial schizophrenia is undefined. This study aims to compare plasma S100 calcium binding protein (S100B) levels patients healthy participants determine if markers independently related with concentration S100B patients. Forty-one thirty-three volunteers were enrolled. Enzyme-linked immunosorbent assay (ELISA) was used assess the concentrations inflammatory markers. We...
Neonatal hyperbilirubinemia is a common clinical condition that can lead to brain encephalopathy, particularly when concurrent with acidosis due infection, ischemia, and hypoxia. The prevailing view increases the permeability of blood-brain barrier bilirubin exacerbates its neurotoxicity. In this study, we found concentration cell death marker, lactate dehydrogenase (LDH) in cerebrospinal fluid (CSF), elevated infants both showed stronger correlation severity rather than increased...
Systemic Lupus Erythematosus (SLE) is a complex and heterogeneous autoimmune disease mediated by quantities of autoantibodies in which anti-double-stranded DNA (anti-dsDNA) antibodies are important. Besides, glycosylation one the most commonly post-translational modifications antibodies. The association anti-dsDNA SLE activity still unknown.We enrolled 101 consecutive treatment-naïve patients with positive from Department Rheumatology Immunology at Ruijin Hospital, Shanghai, between 2017...
Abstract Metabolic reprogramming is a hallmark of malignancy, with profound alterations in cellular metabolism driving cancer progression. However, the precise mechanisms by which these metabolic changes promote tumor growth remain poorly understood. Here we mined activity at single‐cell resolution as well bulk‐RNA levels, and found that cholesterol biosynthesis obviously upregulated breast cancer, particularly triple‐negative cancer. We identified sterol O‐acyltransferase 1 (SOAT1) was...
Abstract Skin soft‐tissue expansion, a key technique for tissue regeneration, promotes repair by applying sustained mechanical tension. However, prolonged tension leads to the accumulation of apoptotic cells and impaired macrophage efferocytosis, thereby disrupting immune homeostasis inhibiting regeneration. In this study, an ultrasound‐driven electric‐conversion hydrogel system (SHG@GBT) is developed, integrating piezoelectric heterojunctions with reorganized network. This modulates...
Abstract Single Nucleotide Polymorphic (SNP) variations of proinflammatory cytokines such as Tumor Necrosis Factor-α (TNF-α) have been reported to be closely associated with the major depressive disorder (MDD). However, it is unclear if genetic burden adversely affects regional gray matter volume in patients MDD. The aim this study was test whether rs1799724, an SNP TNF-α, contributes neuroanatomical changes In cross-sectional study, a total 144 MDD and 111 healthy controls (HC) well matched...
Adult-onset Still's disease (AOSD) is an autoinflammatory with multisystem involvement. Early identification of patients severe complications and those refractory to glucocorticoid crucial improve therapeutic strategy. Exaggerated neutrophil activation enhanced formation extracellular traps (NETs) in AOSD were found be closely associated etiopathogenesis. In this study, we aim investigate, our knowledge for the first clinical value circulating NETs by machine learning distinguish organ...
In December, 2019, an outbreak of the novel coronavirus (SARS-CoV-2) that causes disease 2019 (COVID-19) occurred in Wuhan, China,1Huang C Wang Y Li X et al.Clinical features patients infected with China.Lancet. 2020; 395: 497-506Summary Full Text PDF PubMed Scopus (33099) Google Scholar and soon spread all over world. Rapid accurate diagnosis SARS-CoV-2 infection is cornerstone efforts to stem its advancement. Molecular detection via RT-PCR can result falsely negative results due low viral...