A5100347468- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- Magnesium Alloys: Properties and Applications
- Advanced Sensor and Energy Harvesting Materials
- Corrosion Behavior and Inhibition
- Silk-based biomaterials and applications
- Nerve injury and regeneration
- Aluminum Alloys Composites Properties
- Wound Healing and Treatments
- Urinary Tract Infections Management
- biodegradable polymer synthesis and properties
- Conducting polymers and applications
- Pelvic floor disorders treatments
- Bone Tissue Engineering Materials
- Reproductive tract infections research
- Polymer Surface Interaction Studies
- Sarcoma Diagnosis and Treatment
- Orthopaedic implants and arthroplasty
- Neuroinflammation and Neurodegeneration Mechanisms
- RNA Interference and Gene Delivery
- Supercapacitor Materials and Fabrication
- Pancreatic function and diabetes
- Surface Modification and Superhydrophobicity
- Metal and Thin Film Mechanics
- Magnesium Oxide Properties and Applications
Ruijin Hospital
2021-2025
Tongji University
2012-2025
Shanghai Jiao Tong University
2021-2025
Shanghai Chest Hospital
2025
Tongji Hospital
2016-2025
Gaochun People's Hospital
2025
Jiangsu University
2025
Yale University
2017-2024
Nanjing Tech University
2024
Wenzhou Medical University
2024
Tubulointerstitial fibrosis is a common consequence of various kidney diseases that lead to end-stage renal failure, and lymphocyte infiltration plays an important role in fibrosis. We previously found depletion cluster differentiation 8⁺ (CD8⁺) T cells increases following ureteric obstruction, interferon-γ (IFN-γ)-expressing CD8⁺ contribute this process. are cytotoxic cells; however, whether their effect reduces remains unknown. This study showed isolated from obstructed mRNA expression the...
Microglia play a role in the emergence and preservation of healthy brain microenvironment. Dysfunction microglia has been associated with neurodevelopmental neurodegenerative disorders. Investigating function human health disease challenging due to limited models available. Here, we develop method generate functional cortical organoids (hCOs) from embryonic stem cells (hESCs). We apply this system study during inflammation induced by amyloid-β (Aβ). The overexpression myeloid-specific...
Stenting is currently the major therapeutic treatment for cardiovascular diseases. However, nonbiogenic metal stents are inclined to trigger a cascade of cellular and molecular events including inflammatory response, thrombogenic reactions, smooth muscle cell hyperproliferation accompanied by delayed arterial healing, poor reendothelialization, thus leading restenosis along with late stent thrombosis. To address prevalence critical problems, we present an endothelium-mimicking coating...
Abstract Background Most of the natural extracellular matrix (ECM) is a three-dimensional (3D) network structure micro/nanofibers for cell adhesion and growth 3D. Electrospun fibers distinctive mimicked 2D ECM, however, it impossible to simulate 3D ECM because longitudinal collapse continuous micro/nanofibers. Herein, electrospun micro/nano-fibrous sponge was fabricated via electrospinning, homogenization, shaping thermal crosslinking tissue regeneration cells vascular. Results Fibrous...
Due to the lack of sufficient elasticity and strain sensing capability, protein-based ultrafine fibrous tissue engineering scaffolds, though favorable for skin repair, can hardly fulfill on-spot wound monitoring during healing. Herein, we designed highly elastic corn protein smart scaffolds with a three-layer structure motion tracking at an unpackaged state. The densely cross-linked networks were efficiently established by introducing reactive epoxy provided fiber substrates wide-range...
Abstract Novel biological vascular conduits, such as decellularized tissue engineered grafts (TEVGs) are hindered by high thrombogenicity. To mimic the antithrombogenic surface of native vessels with a continuous glycosaminoglycan layer that is present on endothelial cells (ECs), hyaluronic acid (HA) modified established, to effectively shield blood platelets from collagen‐triggered activation. Using amine groups 4 mm diameter TEVGs, HA hydrogel coating built via bifunctional thiol‐reactive...
Abstract Accumulation of inorganic nanoparticles in living organisms can cause an increase cellular reactive oxygen species (ROS) a dose-dependent manner. Low doses have shown possibilities to induce moderate ROS increases and lead adaptive responses biological systems, but beneficial effects such on metabolic health remain elusive. Here, we report that repeated oral administrations various nanoparticles, including TiO 2 , Au, NaYF 4 at low doses, promote lipid degradation alleviate...
Inflammation plays an important role in atherosclerosis. Arginase I (Arg I) promotes the proliferation of vascular smooth muscle cells; however, effect Arg on inflammation remains unknown. The present study investigated vitro and vivo.Quantitative reverse transcription-polymerase chain reaction Western blot analysis demonstrated that inhibited tumor necrosis factor-α production induced by lipopolysaccharide human aortic cells. Inducible nitric oxide synthase substrate competition nuclear...
Regenerative medicine aims to provide solutions for structural and functional recovery in conditions where organs suffer from varying degrees of diseases or injuries. However, the exogenous inflammation triggered by implanted biomaterials endogenous caused some disease tissue destruction has not been solved properly yet. Herein, a "inner-outer" medicated core-shell electrospun fibrous membrane is fabricated with RGD surface modification suppression puerarin loading core long-term inhibition...
Abstract Reactive astrogliosis is the main cause of secondary injury to central nerves. Biomaterials can effectively suppress astrocyte activation, but mechanism remains unclear. Herein, Differentially Expressed Genes (DEGs) are identified through whole transcriptome sequencing in a mouse model spinal cord injury, revealing VIM gene as pivotal regulator reactive astrocytes. Moreover, DEGs predominantly concentrated extracellular matrix (ECM). Based on these, 3D injectable electrospun short...