A5041836190- Chronic Disease Management Strategies
- Health disparities and outcomes
- Healthcare Systems and Reforms
- Global Health Care Issues
- Diet and metabolism studies
- Birth, Development, and Health
- Dementia and Cognitive Impairment Research
- Spinal Fractures and Fixation Techniques
- COVID-19 epidemiological studies
- Health Systems, Economic Evaluations, Quality of Life
- Cardiac Health and Mental Health
- Cerebrovascular and Carotid Artery Diseases
- Cancer-related molecular mechanisms research
- Health, Environment, Cognitive Aging
- Advanced Memory and Neural Computing
- Neurological Disease Mechanisms and Treatments
- Climate Change and Health Impacts
- Blood Pressure and Hypertension Studies
- Obesity, Physical Activity, Diet
- Ferroelectric and Negative Capacitance Devices
- Scoliosis diagnosis and treatment
- Acute Ischemic Stroke Management
- Healthcare Policy and Management
- Estrogen and related hormone effects
- Frailty in Older Adults
The University of Queensland
2017-2025
Second Affiliated Hospital of Zhejiang University
2020-2025
Shihezi University
2024-2025
Sun Yat-sen Memorial Hospital
2015-2025
Sun Yat-sen University
2015-2025
Chinese Academy of Inspection and Quarantine
2025
Zhejiang University
2019-2024
Hunan Agricultural University
2022-2024
Anhui University
2016-2024
Shanghai Sixth People's Hospital
2008-2024
Inflammatory and immune responses triggered by brain ischemia worsen clinical outcomes of stroke contribute to hemorrhagic transformation, massive edema, reperfusion injury associated with intravenous alteplase. We assessed whether a combination the immune-modulator fingolimod alteplase is safe effective in attenuating patients acute ischemic treated within first 4.5 hours symptom onset.In this multicenter trial, we randomly assigned 25 eligible hemispheric stemming from anterior or middle...
Glioma, with varying malignancy grades and histological subtypes, is the most common primary brain tumor in adults. Long noncoding RNAs (lncRNAs) are non-protein-coding transcripts have been proven to play an important role tumorigenesis. Our study aims elucidate combined effect of lncRNA maternally expressed gene 3 (MEG3) microRNA-19a (miR-19a) human glioma U87 U251 cell lines. Real-time PCR revealed that MEG3 was downregulated miR-19a upregulated malignant tissues Bioinformatics analyses...
To summarize global research trends and activities on multimorbidity; then to assess the knowledge gaps identify implications for exchange between high income countries (HICs) low- middle- (LMICs).A comprehensive search was conducted publications multimorbidity in Web of ScienceTM, as well diabetes, depression, hypertension, Chronic Obstructive Pulmonary Disease (COPD). The time frame from 1900 June, 2016. Information (such publication date, subject category, author, country origin, title,...
Background The prevalence of diabetes, heart disease, and stroke multimorbidity (co-occurrence two or three these conditions) has increased rapidly. Little is known about how the conditions progress from one to another sequentially through life course. We aimed delineate this progression in middle-aged women determine roles common risk factors accumulation multimorbidity. Methods findings used data 13,714 aged 45–50 years without a history any conditions. They were participants Australian...
Abstract STUDY QUESTION Is age at natural menopause (ANM) associated with the development of multiple chronic conditions (multimorbidity) in postmenopausal life? SUMMARY ANSWER Women premature experience increased odds developing individual and multimorbidity. WHAT IS KNOWN ALREADY ANM is considered as a marker age-related morbidity mortality life. Multimorbidity affects more than 60% older women has been recognized most common ‘chronic condition’. Few studies have examined association...
Among patients with a transient ischemic attack or minor strokes, those ipsilateral atherosclerotic stenosis of cervicocranial vasculature have the highest risk recurrent vascular events.
Behavioural risk factors of non-communicable diseases (NCDs) are socially patterned. However, the direction and extent to which socioeconomic status (SES) influences behaviour changes before after diagnosis NCDs is not clearly understood. We aimed investigate influence SES on (physical inactivity smoking) major NCDs.In this multicohort study, we pooled individual-level data from six prospective cohort studies across 17 countries. included participants who were diagnosed with either diabetes,...
BackgroundMany physical, psychological, and cognitive disorders are highly clustered among populations with low socioeconomic status. However, the extent to which status is associated different combinations of these unclear, particularly outside high-income countries. We aimed evaluate associations in 33 countries including countries, upper-middle-income one lower-middle-income country.MethodsThis cross-sectional multi-region study pooled individual-level data from seven studies on ageing...
<h3>Background and aims</h3> Reg4 is a recently discovered member of the regenerating gene family with distinctive expression profiles in primary cancers. To date, physiological function poorly understood. Previously, authors found that was markedly upregulated during acute pancreatitis (AP). The aim this study to investigate role experimental pancreatitis. <h3>Methods</h3> AP induced C57BL/6 mice by administration either l-arginine or caerulein, assessed immunofluorescence, reverse...
Obesity, which is related to increased oxidative stress in various tissues, a risk factor for male infertility. Metformin reported have an antioxidant effect; however, the precise role of metformin obesity-induced infertility remains unknown. The current study aimed at exploring effects and characterizing its underlying mechanism fertility obese males. An mouse model was generated by feeding mice with high-fat diet; then, were administered water 8 weeks. Reproductive ability, metabolic...
Human papillomavirus (HPV) infection is one of the most common sexually transmitted diseases. After studying 602 unvaccinated Chinese women using 16S rRNA to detect cervical-vaginal microecology, we analyzed relationship between HPV and vaginal microecology including 20 types. In women, L. gasseri– dominated jensenii– clusters were significantly absence. Microbial alpha diversity was higher in HPV-infected cervical intraepithelial neoplasia (CIN)–diagnosed groups than healthy control group....
This study assessed the associations of multimorbidity burden and its developmental trajectory with later-life dementia.Among 5923 Health Retirement Study participants, major chronic conditions including hypertension, diabetes mellitus, cancer, lung diseases, heart disease, stroke, psychological disorders, arthritis were self- or proxy-reported in 1994-2008. Dementia diagnosis was 2008-2018. We used Cox regression to assess incident dementia.During follow-up (median = 8 years), 701...
We conducted a prospective study of erectile dysfunction (ED) after urethral reconstructive surgery, using the 5-item International Index Erectile Function (IIEF-5), Sexual Life Quality Questionnaire (SLQQ) and (QoLQ). Between January 2003 July 2007, 125 male patients with strictures underwent urethroplasty, pre- post-surgery function was assessed these three questionnaires. A formula to predict probability ED urethroplasty derived. At 3 months post-operatively, there significant decrease in...