A5107339905- Nicotinic Acetylcholine Receptors Study
- Gestational Diabetes Research and Management
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Cancer-related molecular mechanisms research
- Cardiac Fibrosis and Remodeling
- Pancreatitis Pathology and Treatment
- Circular RNAs in diseases
- Antimicrobial Peptides and Activities
- Neuropeptides and Animal Physiology
- Nutrition and Health in Aging
- Advanced Measurement and Metrology Techniques
- Adipose Tissue and Metabolism
- Signaling Pathways in Disease
- Pancreatic and Hepatic Oncology Research
- Child Nutrition and Water Access
- Chemical Analysis and Environmental Impact
- RNA Research and Splicing
- Heat Transfer Mechanisms
- Advanced Numerical Analysis Techniques
- Muscle Physiology and Disorders
- Water Treatment and Disinfection
- Phagocytosis and Immune Regulation
- Vagus Nerve Stimulation Research
- Immune cells in cancer
Shanghai Sixth People's Hospital
2024-2025
Shanghai Jiao Tong University
2010-2025
International Peace Maternity & Child Health Hospital
2021-2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2022
<h3>Background and aims</h3> Reg4 is a recently discovered member of the regenerating gene family with distinctive expression profiles in primary cancers. To date, physiological function poorly understood. Previously, authors found that was markedly upregulated during acute pancreatitis (AP). The aim this study to investigate role experimental pancreatitis. <h3>Methods</h3> AP induced C57BL/6 mice by administration either l-arginine or caerulein, assessed immunofluorescence, reverse...
Introduction Elevated maternal serum lipid concentrations have been related to an adverse intrauterine environment and lead abnormal birth weight. Objective In this study, we aimed explore the association between profiles during early pregnancy weight with stratified pre-pregnancy body mass index (BMI). Methods This retrospective cohort study was based on a large population from two major maternity centers in Shanghai, China. We included 57,516 women singleton live January 2018 October 2020....
Abstract Cardiovascular diseases are an array of age-related disorders, and accumulating evidence suggests a link between cardiac resident macrophages (CRMs) the disorders. However, how does CRMs alter with aging remains elusive. In present study, aged mice (20 months old) have been employed to check for their structural functional alterations, changes in proportion CRM subsets as well, followed by sorting CRMs, including C-C Motif Chemokine Receptor 2 (CCR2) + CCR2 – which were subjected...
Abstract Skeletal muscle function gradually declines with aging, presenting substantial health and societal challenges. Comparative analysis of how aging affects fast‐ slow‐twitch muscles remains lacking. We utilized 20‐month‐old mice to reveal the effects on structure fiber composition, followed by bulk RNA sequencing for integration human single‐cell dataset providing a comparative across species. In mouse muscles, induced switch from fast slow fibers distinctively altered lipid metabolism...
Nicotinic ACh receptors containing the α7 sub-unit (α7-nAChRs) suppress inflammation through a wide range of pathways in immune cells. These are thus potentially involved number inflammatory diseases. However, detailed mechanisms underlying anti-inflammatory effects α7-nAChRs remain to be described.Anti-inflammatory α7-nAChR agonists were assessed both murine macrophages (RAW 264.7) and bone marrow-derived (BMDM), stimulated with LPS, using immunoblotting, RT-PCR luciferase reporter assays....
The manufacture of film cooling holes on turbine guide vanes an aeroengine suffers from the contour errors resulting a casting process. It is therefore necessary to adjust positions and orientations for each vane. This article proposes adaptive compensation machining method based combination principal component analysis (PCA) iterative closest point (PCA-ICP) registration orthocenter mapping method. First, carried out between ideal cloud measured by laser measurement machine obtain...
Chloramine and chloroform are widespread in tap water due to disinfection processes. This study was designed explore the associations between trimester-specific exposure chloramine adverse outcomes. retrospective cohort included 109,182 mother–infant singleton pairs Shanghai. A logistic regression model used evaluate of concentrations averaged over whole pregnancy each trimester with outcomes, including gestational diabetes mellitus (GDM), hypertensive disorders (GHD), low birthweight (LBW),...
Background and purpose: Alpha 7 nicotinic acetylcholine receptors (CHRNA7) suppress inflammation through diverse pathways in immune cells, so is potentially involved a number of inflammatory diseases. However, the detailed mechanisms underlying CHRNA7’s anti-inflammatory effects remain elusive. Experimental approach: The CHRNA7 agonists both murine macrophages (RAW 264.7) bone marrow-derived (BMDM) stimulated with LPS were examined. role adenylyl cyclase 6 (AC6) Toll-like Receptor 4 (TLR4)...