A5016741649- Lung Cancer Research Studies
- Head and Neck Cancer Studies
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA modifications and cancer
- Crystallography and molecular interactions
- Cytokine Signaling Pathways and Interactions
- Radiomics and Machine Learning in Medical Imaging
- Brain Metastases and Treatment
- RNA Research and Splicing
- PI3K/AKT/mTOR signaling in cancer
- Ferroptosis and cancer prognosis
- NF-κB Signaling Pathways
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- Neonatal Respiratory Health Research
- Cancer Mechanisms and Therapy
- Nuclear Structure and Function
- Cancer Cells and Metastasis
- Aquaculture disease management and microbiota
- Cancer Research and Treatments
- Immune cells in cancer
Southern Medical University
2019-2024
Nanfang Hospital
2019-2024
Harbin Medical University
2024
Hunan Agricultural University
2020-2024
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2024
Chongqing Medical University
2024
Tianjin International Joint Academy of Biomedicine
2024
Tianjin Third Central Hospital
2024
Tianjin Medical University
2024
Shanghai Sixth People's Hospital
2024
Copper (Cu), a crucial trace element in physiological processes, has garnered significant interest for its involvement cancer progression and potential therapeutic applications. The regulation of cellular copper levels is essential maintaining homeostasis, as imbalances can lead to toxicity cell death. development drugs that target homeostasis emerged promising strategy anticancer treatment, with particular focus on chelators, ionophores, novel complexes. Recent research also investigated...
Irradiation has emerged as a valid tool for nasopharyngeal carcinoma (NPC) in situ treatment; however, NPC derived from tissues treated with irradiation is main cause cancer-related death. The purpose of this study to uncover the underlying mechanism regarding tumor growth after and provided potential therapeutic strategy.Fibroblasts were extracted fresh tissue normal mucosa. Immunohistochemistry was conducted measure expression α-SMA FAP. Cytokines detected by protein array chip identified...
Radiotherapy is a conventional and effective local treatment for breast cancer. However, residual or recurrent tumors appears frequently because of radioresistance. Novel predictive marker the potential therapeutic targets cancer radioresistance needs to be investigated.In this study, we screened all 10 asparagine-linked glycosylation (ALG) members in patients' samples by RT-PCR. Cell viability after irradiation (IR) was determined CCK-8 assay flow cytometry. The radiosensitivity cell lines...
Long noncoding RNAs (lncRNAs) have been illustrated to function as important regulator in carcinogenesis and cancer progression. However, roles of lncRNA miR210HG (miR210 host gene) osteosarcoma remain unclear. In this study, expression level was significantly upregulated 55 cases tissue samples compared adjacent normal tissue. Besides, the aberrantly enhanced predicted poor prognosis lower survival rate. vitro, knockdown suppressed cell proliferation, invasion, epithelial–mesenchymal...
Abstract Tumor metastasis is one of the major causes high mortality in patients with hepatocellular carcinoma (HCC). Sustained activation STAT3 signaling plays a critical role HCC metastasis. RNA binding protein (RBP)–mediated posttranscriptional regulation involved precise control signal transduction, including signaling. In this study, we investigated whether RBPs are important regulators The RBP MEX3C was found to be significantly upregulated highly metastatic and correlated poor...
Abstract Cardiovascular diseases are an array of age-related disorders, and accumulating evidence suggests a link between cardiac resident macrophages (CRMs) the disorders. However, how does CRMs alter with aging remains elusive. In present study, aged mice (20 months old) have been employed to check for their structural functional alterations, changes in proportion CRM subsets as well, followed by sorting CRMs, including C-C Motif Chemokine Receptor 2 (CCR2) + CCR2 – which were subjected...
The Copper Metabolism MURR1 (COMM) domain family has been reported to play important roles in tumorigenesis. As a prototype for the COMMD family, expression pattern and biological function of COMMD6 human tumours remain unknown.COMMD6 BALB/c mice tissues was examined using real-time PCR immunohistochemistry. Kaplan-Meier analysis applied evaluate prognosis tumours. Competing endogenous RNA (ceRNA) transcriptional regulation network were constructed based on differentially expressed mRNAs,...
Ischemic stroke is the major form of and accentuated by multiple comorbidities. It has been previously shown that different microRNAs (miRNAs) regulate separate aspects ischemic stroke. Differential miRNA expression analysis in cerebrospinal fluid patients had revealed upregulation miR-124-3p, miR-9-3p, miR-9-5p, miR-128-3p. However, whether overexpression correlative or causative was not known. Here, using an vitro oxygen-glucose deprivation/reoxygenation (OGD/R) neuronal cell model, we saw...
Dihydrotanshinone I (DHTS), extracted from Salvia miltiorrhiza, was found to be the most effective compound of tanshen extracts against cancer cells in our previous studies. However, therapeutic benefits and underlying mechanisms DHTS on ovarian remain uncertain. In this study, we demonstrated cytocidal effects chemosensitive with or without platinum-based chemotherapy. able inhibit proliferation migration vitro vivo through modulation PI3K/AKT signalling pathways. Combinatorial treatment...
Pulmonary surfactant protein A1 (SFTPA1) is a member of the C-type lectin subfamily that plays critical role in maintaining lung tissue homeostasis and innate immune response. SFTPA1 disruption can cause several acute or chronic diseases, including cancer. However, little research has been performed to associate with cell infiltration response immunotherapy The findings our study describe expression profile multiple databases was validated BALB/c mice, human tumor tissues, paired normal...
The efficacy of induction chemotherapy (IC) as a primary treatment for advanced nasopharyngeal carcinoma (NPC) remains topic debate, with lack dependable biomarkers predicting its efficacy. This study seeks to establish predictive classifier using plasma metabolomics profiles.
Abstract Background Hepatocellular carcinoma (HCC) is the third leading cause of cancer mortality worldwide. Currently, there limited knowledge dysregulation cellular proliferation and apoptosis that contribute to malignant phenotype in HCC. Copper metabolism gene MURR1 domain 10 (COMMD10) initially identified as a suppressor pathogenesis HCC our observations. Here we aimed explore its function prognostic value progression Methods Functional experiments were performed role COMMD10 The...
Macropinocytosis is an effective strategy to mitigate nutrient starvation. It can fuel cancer cell growth in nutrient-limited conditions. However, whether and how macropinocytosis contributes the rapid proliferation of hepatocellular carcinoma cells, which frequently experience inadequate supply, remains unclear. Here, we demonstrated that starvation strongly induced some cells. allowed cells acquire extracellular nutrients supported their energy supply maintain proliferation. Furthermore,...
Plasma proteins are considered the most informative source of biomarkers for disease diagnosis and monitoring. Mass spectrometry (MS)-based proteomics has been applied to identify in plasma, but complexity plasma proteome extremely large dynamic range protein abundances make clinical application highly challenging. We designed synthesized zeolite-based nanoparticles deplete high-abundance proteins. The resulting novel proteomic assay can measure approximately 3000 a 45 min chromatographic...
Elderly individuals undergoing surgical procedures are often confronted with the peril of experiencing postoperative cognitive dysfunction (POCD). Prior research has demonstrated exacerbating effect sevoflurane anesthesia on neuroinflammation, which can further deteriorate condition POCD in elderly patients. Intermittent fasting (IF) restricts food consumption to a specific time window and been ameliorate induced by neuropathic inflammation. We subjected 18-month-old male mice 16 hours 8...
The gonad is the major factor affecting animal reproduction. regulatory mechanism of expression protein-coding genes involved in reproduction still remains to be elucidated. Increasing evidence has shown that ncRNAs play key roles gene many life processes. microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) have been investigated some species. However, patterns miRNA lncRNA sex biased protein coding In this study, we performed an integrated analysis miRNA, messenger RNA (mRNA), profiles...
Single ionizing radiation at a tolerable dose is ineffectual in eliminating malignancies but readily generates harmful effects on surrounding normal tissues. Herein, we intelligently fabricated novel wolfram-doped polypyrrole (WPPy) through simple oxidative polymerization method with WCl6 as an oxidizing catalyst, which possessed good biocompatibility, high photothermal conversion, and intensive radiosensitivity capacities to concurrently serve reagent radiosensitizer for...
CHST4 plays an important role in lymphocyte homing and is abnormally expressed several cancer types; however, its precise function tumor development progression unknown. Here we confirm that aberrantly various subtypes. In particular, found expression was downregulated hepatitis B virus-related hepatocellular carcinoma (HBV-HCC) tumors compared to paired normal tissue. We also showed overexpression inhibited the proliferation metastasis of HCC cells vitro. Clinically, identified as...
To explore the influence of perinatal-related factors on meconium aspiration syndrome (MAS) in full-term neonates and construct a nomogram prediction model for risk stratification neonatal MAS adoption preventive measures. A total 424 newborns their mothers who were regularly examined at our hospital between January 2020 December 2023 had meconium-contaminated amniotic fluid during delivery retrospectively selected as participants. Neonates divided into non-MAS groups based whether occurred...