A5103018732- Acute Ischemic Stroke Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Myasthenia Gravis and Thymoma
- Neurological Disorders and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Ion channel regulation and function
- Cellular transport and secretion
- Cardiac Fibrosis and Remodeling
- Enzyme function and inhibition
- Alzheimer's disease research and treatments
- Axon Guidance and Neuronal Signaling
- Long-Term Effects of COVID-19
- Dementia and Cognitive Impairment Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Adipokines, Inflammation, and Metabolic Diseases
- Cannabis and Cannabinoid Research
- Immune cells in cancer
- Neurological disorders and treatments
- Neurogenesis and neuroplasticity mechanisms
- Cardiovascular Disease and Adiposity
- Immune Response and Inflammation
- Intracranial Aneurysms: Treatment and Complications
- Cardiovascular Health and Disease Prevention
- MRI in cancer diagnosis
- Endoplasmic Reticulum Stress and Disease
Songjiang District Central Hospital
2024-2025
Shanghai Jiao Tong University
2017-2025
Tongren Hospital
2015-2024
Second Affiliated Hospital of Zhejiang University
2009-2015
Fudan University
2004
Background: High-resolution magnetic resonance vessel wall imaging (HRMR-VWI) is a promising technique for identifying intracranial vulnerable plaques beyond lumen narrowing. However, the association between HRMR-VWI characteristics and recurrent stroke remains uncertain. Aims: This study aimed to investigate ipsilateral in patients with symptomatic atherosclerotic steno-occlusive disease (ICAS). Methods: multicenter, observational recruited first-ever acute ischemic attributed ICAS (>50%...
Abstract Cardiovascular diseases are an array of age-related disorders, and accumulating evidence suggests a link between cardiac resident macrophages (CRMs) the disorders. However, how does CRMs alter with aging remains elusive. In present study, aged mice (20 months old) have been employed to check for their structural functional alterations, changes in proportion CRM subsets as well, followed by sorting CRMs, including C-C Motif Chemokine Receptor 2 (CCR2) + CCR2 – which were subjected...
Serum metabolites from 19 myasthenia gravis (MG) patients and 15 normal controls were analyzed via untargeted metabolomics, including 6 pre/post-treatment paired MG patients, to assess the value of serum as biomarkers in monitoring MG.
ABSTRACT Integrating dietary interventions have been extensively studied for their health benefits, such as Alzheimer's disease, Huntington's and aging. However, it is necessary to fully understand the mechanisms of long‐term effects practical applications these health. A 10‐week intermittent fasting (IMF) regimen was implemented on aging animals in current study. The variations cerebral functions were analyzed employing a comprehensive experimental design that includes behavioral tests,...
Background and Purpose- Studies on the prevalence risk factors of white matter lesions (WMLs) in Tibetans living at high altitudes are scarce. We conducted this study to determine risks WMLs Tibetan patients without or with nonacute stroke. Methods- undertook a retrospective analysis medical records treated People's Hospital Autonomous Region identified total 301 acute WML severity was graded by Fazekas Scale. assessed overall age-specific analyzed associations between related univariate...
Myasthenia gravis (MG) is considered as an autoimmune disease mainly mediated by antibodies against acetylcholine receptor. In recent years, other targets related to MG have been the subject of interest. Our previous research found that protein P25 was lower in muscles patients using two-dimensional electrophoresis. present study, anti-serum prepared, immunohistochemistry and ATPase staining revealed a muscle specific cytosolic distributed type I fibers. Matrix-assisted laser...
Proper intracellular localization of TLRs is essential for their signaling and biological function. Endocytosis constitutes a key step in protein turnover, as well maintenance TLR plasma membrane compartments, thus provides important regulating points to signaling. In this study, we demonstrate that adenylyl cyclase (AC) activation attenuates TLR4 murine macrophage cell line (RAW 264.7) bone marrow-derived macrophages when stimulated with LPS. We further show the AC6 isoform plays role...
Myasthenia gravis is an autoimmune disorder of the neuromuscular junction manifested as fatigable muscle weakness, which typically caused by pathogenic autoantibodies against postsynaptic CHRN/AChR (cholinergic receptor nicotinic) in endplate skeletal muscle. Our previous studies have identified CA3 (carbonic anhydrase 3) a specific protein insufficient from myasthenia patients. In this study, we investigated underlying mechanism how insufficiency might contribute to gravis. Using...
Numerous studies on acute ischemic stroke (AIS) have been conducted at low-altitude regions, and the related findings used to guide clinical management. However, corresponding high altitude are few. This study aimed analyse characteristics of AIS patients high-altitude regions through a hospital-based comparative between Tibet Beijing.This included diagnoses from People's Hospital Autonomous Region (PHOTAR) Peking University First (PUFH) 1 January 2014 31 December 2017, where data including...
Intracranial atherosclerosis (ICAS) is a major cause of stroke worldwide. However, much remains unknown regarding its underlying pathophysiology. High-resolution magnetic resonance imaging (HR-MRI) can clearly display intracranial vessel wall lesions in vivo. The aim package study ICAS (SIPS-ICAS) to explore the mechanisms symptomatic ICAS, dynamic changes under aggressive medical treatment and their associations with clinical events using conventional MRI sequences plus HR-MRI.This...
Abstract We reported four patients with coronavirus disease 2019 (COVID-19)–associated myelopathies, highlighting the delayed and atypical spinal cord magnetic resonance imaging (MRI) features literature review. All were males, aged 37 to 72 years old. The latencies from COVID-19 onset of myelitis 5, 15, 30, 80 days. initial symptoms numbness weakness lower limbs in three cases, back pain one case. peak included paraplegia, sphincter dysfunction, sensory disturbance level, spastic gait. EDSS...
Background A high-fat diet (HFD) contributes to various metabolic disorders and obesity, which are major contributors cardiovascular disease. As an essential regulator for heart homeostasis, cardiac resident macrophages may go awry contribute pathophysiology upon HFD. Thus, better understand how HFD induced dysfunction, this study intends explore the transcriptional functional changes in of mice. Methods C57BL/6J female mice that were 6 weeks old fed with or normal chow (NCD) 16 weeks. After...
Introduction In China, the increasing number of people with Alzheimer's disease (AD) poses a great challenge to families and country. Economic cultural differences cause urban-rural gap in medical resources. This multicenter survey aimed investigate real-world practice treatment among AD. Methods People AD their caregivers from 30 provincial regions mainland China were enrolled October 2020 December be surveyed for experience. Logistic regression was used explore factors that influence...
Background and Objectives: This study aimed to investigate the association between high-resolution magnetic resonance imaging (HR-MRI) characteristics recurrent ipsilateral stroke in patients with symptomatic intracranial atherosclerotic steno-occlusive disease (ICAS). Methods: multicenter, observational recruited first-ever acute ischemic attributed ICAS (>50% stenosis or occlusion) within 7 days after onset. Participants were assessed by multi-parametric MRI including diffusion-weighted...
Abstract Background: Numerous studies on acute ischemic stroke (AIS) have been conducted at low-altitude regions, and the related findings used to guide clinical management. However, corresponding high altitude are few. This study aimed analyse characteristics of AIS patients high-altitude regions through a hospital-based comparative between Tibet Beijing. Methods: included diagnoses from People’s Hospital Autonomous Region (PHOTAR) Peking University First (PUFH) 1 January 2014 31 December...
Purpose: We aimed to investigate the prevalence and clinical relevance of parent artery plaque in acute lacunar stroke. Methods: This prospective, multi-center, observational study included patients with first-ever ischemic stroke within 72 hours symptom onset. Patients were evaluated by three-dimensional T1-weighted high-resolution magnetic resonance imaging (HR-MRI) conventional MRI sequences. examined presence intracranial plaque, infarction patterns, infarct volumes all The outcome...
Abstract Background: Numerous studies of acute ischemic stroke (AIS) have been conducted at low altitude regions, and the related findings were used to instruct clinic management while corresponding high are few. This study aimed analyse AIS characteristics regions by conducting a hospital-based comparative between Tibet Beijing. Methods: included diagnoses patients from People’s Hospital Autonomous Region (PHOTAR) Peking University First (PUFH) 1 st January 2014, 31 December 2017, where...
Abstract Background: Lots of studies acute ischemic stroke (AIS) had been conducted at low altitude regions, and related findings were used to instruct clinic management while corresponding high few. This study aimed analyse AIS characteristics regions by conducting a hospital-based comparative between Tibet Beijing. Methods: included the diagnoses patients from People’s Hospital Autonomous Region (PHOTAR) Peking University First (PUFH) 1st January 2014, 31st December 2017, where data...
Abstract Background : Numerous studies on acute ischemic stroke (AIS) have been conducted at low-altitude regions, and the related findings used to guide clinical management. However, corresponding high altitude are few. This study aimed analyse characteristics of AIS patients high-altitude regions through a hospital-based comparative between Tibet Beijing. Methods: included diagnoses from People’s Hospital Autonomous Region (PHOTAR) Peking University First (PUFH) 1 January 2014 31 December...
Abstract Background Lots of studies acute ischemic stroke (AIS) had been conducted at low altitude regions, and related findings were used to instruct clinic management while corresponding high few. This study aimed analyse AIS characteristics regions by conducting a hospital-based comparative between Tibet Beijing. Methods included diagnoses patients from People’s Hospital Autonomous Region (PHOTAR) Peking University First (PUFH) 1st January 2014, 31st December 2017, where data including...
Objective: To report two congenital myasthenic syndromes (CMS) from a Chinese family due to mutations in COLQ gene and prove the consequence defect of ColQ peptides.Method: Clinical characteristics children were descripted. Next-generation sequencing (NGS) Sanger performed on proband members. The mutation was predicted by 3D protein structures prediction using I-TASSER. wild type mutant transfected 293T cells peptides detected Western Blot.Results: diagnosis CMS based symptom combination...