A5100525843- Photodynamic Therapy Research Studies
- Nanoplatforms for cancer theranostics
- Ultrasound and Hyperthermia Applications
- Autophagy in Disease and Therapy
- Cancer, Hypoxia, and Metabolism
- Photoacoustic and Ultrasonic Imaging
- Ultrasound and Cavitation Phenomena
- Immune Response and Inflammation
- Heme Oxygenase-1 and Carbon Monoxide
- Atherosclerosis and Cardiovascular Diseases
- Curcumin's Biomedical Applications
- Inflammasome and immune disorders
- Retinoids in leukemia and cellular processes
- Antimicrobial Peptides and Activities
- Cardiac Fibrosis and Remodeling
- Porphyrin and Phthalocyanine Chemistry
- Biofuel production and bioconversion
- Viral Infections and Immunology Research
- Immune cells in cancer
- Signaling Pathways in Disease
- Ion channel regulation and function
- Tissue Engineering and Regenerative Medicine
- Myasthenia Gravis and Thymoma
- Nanoparticle-Based Drug Delivery
- Ultrasound Imaging and Elastography
Shanghai Sixth People's Hospital
2020-2025
Shanghai Jiao Tong University
2013-2025
Fuyang Second People's Hospital
2025
Anhui Medical University
2025
State Key Laboratory of Respiratory Disease
2022-2024
Guangzhou Medical University
2018-2024
Heilongjiang Bayi Agricultural University
2019-2024
Qingdao University
2024
Affiliated Hospital of Qingdao University
2024
Ministry of Agriculture and Rural Affairs
2024
IL-17 is one of the most potent and actively investigated proinflammatory cytokines. In this study, we examined effect on mesenchymal stem cells (MSCs) under influence inflammatory Ironically, dramatically enhanced immunosuppressive MSCs induced by IFNγ TNFα, revealing a novel role in immunosuppression. Interestingly, found that action was dependent promoted expression key immune suppressive molecule, inducible nitric oxide synthase (iNOS), MSCs. concanavalin A (ConA)-induced hepatitis mouse...
High-fat diet (HFD) leads to systemic low-grade inflammation, which has been involved in the pathogenesis of diverse metabolic and inflammatory diseases. Colon is thought be first organ suffering from inflammation under HFD conditions due pro-inflammatory macrophages infiltration, however, mechanisms concerning induction phenotype colonic remains unclear. In this study, we show that increased percentage gram-positive bacteria, especially genus Clostridium, resulted significant increment...
Scope The NLRP3 inflammasome responds to various pathogen‐derived factors and danger‐associated molecules, mediating IL‐1β maturation, therefore is involved in multiple inflammatory diseases. Curcumin has been shown possess strong anti‐inflammatory activity, but the underlying mechanism not fully understood. Here, we sought investigate role of curcumin on inhibition mature production via regulation inflammasome. Methods results dramatically inhibited LPS‐primed macrophages triggered by...
// Zizhen Gong 1,2,3,* , Jiefei Zhou Shengnan Zhao Chunyan Tian 4,5 Panliang Wang 1 Congfeng Xu 6 Yingwei Chen 2,3 Wei Cai 1,2,3 and Jin Wu Department of Pediatric Surgery, Xinhua Hospital, Shanghai Jiaotong University School Medicine, Shanghai, China 2 Institute for Research, 3 Key Laboratory Gastroenterology Nutrition, 4 State Proteomics, National Center Proteomics Science (Beijing), Beijing Radiation Beijing, 5 Engineering Research Protein Drugs, Immunology, Institutes Medical Sciences, *...
Mesenchymal stem cell (MSC)-based therapy is a promising approach to treat various inflammatory disorders including multiple sclerosis. However, the fate of MSCs in microenvironment largely unknown. Experimental autoimmune encephalomyelitis (EAE) well-studied animal model We demonstrated that autophagy occurred during their application for EAE treatment. Inflammatory cytokines, e.g., interferon gamma and tumor necrosis factor, induced synergistically by inducing expression BECN1/Beclin 1....
Autophagy is an evolutionarily conserved biological process involved in array of physiological and pathological events. Without proper control, autophagy contributes to various disorders, including cancer autoimmune inflammatory diseases. It therefore vital importance that under careful balance. Thus, additional regulators undoubtedly deepen our understanding the working network, provide potential therapeutic targets for disorders. In this study, we found RNF216 (ring finger protein 216), E3...
A westernized high-fat diet (HFD) is associated with the development of inflammatory bowel disease (IBD). High level fecal deoxycholic acid (DCA) caused by HFD contributes to colonic injury IBD, however, mechanism concerning initiation response DCA remains unclear. In this study, we sought investigate role and in induction inflammation via promoting NLRP3 inflammasome activation. Here for first time showed that dose-dependently induced activation highly pro-inflammatory cytokine-IL-1β...
Objective. The purpose of the study was to explore antitumor effect docetaxel-loaded lipid microbubbles combined with ultrasound-targeted microbubble activation (UTMA) on VX2 rabbit liver tumors. Methods. Docetaxel-loaded were made by a mechanical vibration technique. tumor models established in 90 rabbits, which randomly divided into 6 groups, including control, docetaxal-loaded alone, docetaxal ultrasound, pure and ultrasound (DOC+MB/US). volume inhibition rate (IR) growth calculated...
Autophagy is one of the downstream effector mechanisms for elimination intracellular microbes following activation Toll-like receptors (TLRs). Although detailed molecular mechanism this cellular process still unclear, Beclin 1, a key molecule autophagy, has been suggested to play role. Heat shock protein 90 (Hsp90) chaperone that regulates stability signaling proteins. Herein, we show Hsp90 forms complex with 1 through an evolutionarily conserved domain maintain 1. In monocytic cells,...
We recently have proved that excessive fecal DCA caused by high-fat diet may serve as an endogenous danger-associated molecular pattern to activate NLRP3 inflammasome and thus contributes the development of inflammatory bowel disease (IBD). Moreover, effect on activation is mainly mediated through bile acid receptor sphingosine-1-phosphate 2 (S1PR2); however, intermediate process remains unclear. Here, we sought explore detailed mechanism involved examine S1PR2 blockage in a colitis mouse...
Development of new photosensitizers (PSs) with high photodynamic efficacy and minimal side effects is great interest in therapy (PDT). In this work, we reported several pyridine-embedded phenothiazinium (pyridophenothiazinium) dyes, which could be conveniently synthesized a few short steps acted as highly efficient potent PSs to selectively localize lysosomes photosensitively kill cancer cells. Among them, compound 5, possessed the ability promoting intracellular reactive oxygen species...
Photodynamic therapy (PDT) is a minimally invasive treatment for many diseases, including infections and tumors. Nevertheless, clinical utilization of PDT severely restricted due to the shortcomings photosensitizers, especially their low water solubility poor tumor selectivity. iRGD (internalizing RGD, CRGDKGPDC), nine-unit cyclic peptide, was applied as an active ligand realize homing tissue penetration. Herein, we innovatively fabricated novel OFF-ON mode iRGD-based peptide amphiphile (PA)...
Appropriate fibrosis is required to prevent subsequent adverse remodeling and heart failure post myocardial infarction (MI), cardiac fibroblasts (CFs) play a critical role during the process.Carbonic anhydrase 3 (CAR3) an important mediator in multiple biological processes besides its CO2 hydration activity; however, underlying mechanism of CAR3 on repair MI injury remains unknown.Here, we found that expression was up-regulated tissue infarct area at reparative phase MI, with peak 7 days...
Abstract Cardiovascular diseases are an array of age-related disorders, and accumulating evidence suggests a link between cardiac resident macrophages (CRMs) the disorders. However, how does CRMs alter with aging remains elusive. In present study, aged mice (20 months old) have been employed to check for their structural functional alterations, changes in proportion CRM subsets as well, followed by sorting CRMs, including C-C Motif Chemokine Receptor 2 (CCR2) + CCR2 – which were subjected...
Hepatitis B virus (HBV) infection brings a huge challenge for medical health practitioners. It has been reported that invaded HBV escapes autophagic degradation through inhibiting lysosome maturation following enhanced autophagy formation, which putatively contributes to replication and infection. However, the underlying mechanism by from remains elusive. In this study, we monitored process using HepG2 cells mice without or with transient DNA plasmid transfection (pHepG2) stable (HepG2.2.15...
Tetraspanin CD82 suppresses cell migration, tumor invasion, and metastasis. To determine the mechanism by which inhibits motility, most studies have focused on surface CD82, forms tetraspanin-enriched microdomains (TEMs) with other transmembrane proteins, such as integrins. In this study, we found that undergoes endocytosis traffics to endosomes lysosomes. endocytic of demonstrated dynamin clathrin are not essential for internalization. Depletion or sequestration sterol in plasma membrane...
Adenylyl cyclases (AC) are important regulators of airway smooth muscle function, because β-adrenergic receptor (AR) agonists stimulate AC activity and increase diameter. We assessed expression isoforms in human bronchial cells (hBSMC). Reverse transcriptase-polymerase chain reaction immunoblot analyses detected AC2, AC4, AC6. Forskolin-stimulated membranes from hBSMC displayed Ca<sup>2+</sup>-inhibited G<sub>βγ</sub>-stimulated activity, consistent with AC6, AC4. Isoproterenol-stimulated...